Extents of impact, as measured by NMR spectroscopy, on the Zebrafish liver cell endogenous metabolite profiles resulting from exposure to the 38 stream waters, along with numbers of anthropogenic organic chemicals detected at each site. Also, a summary of chemicals detected by class is included, along with statistics on their occurances in the group of stressors that most-strongly covary with changes in endogenous metabolite profiles. This dataset is associated with the following publication: Collette, T., D. Ekman, H. Zhen, H. Nguyen, P.M. Bradley, and Q. Teng. Cell-Based Metabolomics for Untargeted Screening and Prioritization of Vertebrate-Active Stressors in Streams Across the United States. ENVIRONMENTAL SCIENCE & TECHNOLOGY. American Chemical Society, Washington, DC, USA, 53(15): 9232-9240, (2019).

The instructions for analysis are described in Kolli et al. (2019) along with a sample Illumina sequence file available with a ready-to-run VirtualMachine that can also be accessed at http://toxicology.uga.edu/resources/dna_methylation_analysis/. Supporting data for sequencing and qPCR raw data are available at https://doi.org/10.5281/zenodo.8313356, sharing qPCR raw data files for the endpoint for male and female fish from CFX Manger (Ver. 3.0), qPCR quantification data, TGBS raw sequences, and a TGBS metadata file with sample information. This dataset is associated with the following publication: Kolli, R., T. Glenn, R. Bringolf,, W. Henderson, B. Cummings, and J. Kenneke. Changes in CpG Methylation of the Vitellogenin 1 Promoter in Adult Male Zebrafish after Exposure to 17α-Ethynylestradiol. ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY. Society of Environmental Toxicology and Chemistry, Pensacola, FL, USA, 43(7): 1547-1556, (2024).

Data describe results of a set of laboratory experiments using a previously described quantitative thiaminase I activity assay to test the thiaminase activity of whole zebrafish homogenates. Parameters described include the thiaminase activity data, dilution factors, incubation time, and tissue weight assayed. Experiments were conducted at the USGS Columbia Environmental Research Center, Columbia, MO in 2006.

Data describe results of a set of laboratory experiments using a previously described quantitative thiaminase I activity assay to test the thiaminase activity of whole zebrafish homogenates. Parameters described include the thiaminase activity data, dilution factors, incubation time, and tissue weight assayed. Experiments were conducted at the USGS Columbia Environmental Research Center, Columbia, MO in 2006.

Impacts of U.S. Streams on the Lipidome of Zebrafish Liver Cells. This dataset is associated with the following publication: Zhen, H., Q. Teng, J. Mosley, T. Collette, Y. Yue, P. Bradley, and D. Ekman. Untargeted Lipidomics for Determining Cellular and Subcellular Responses in Zebrafish (Danio rerio) Liver Cells Following Exposure to Complex Mixtures in U.S. Streams. ENVIRONMENTAL SCIENCE & TECHNOLOGY. American Chemical Society, Washington, DC, USA, 55(12): 8180–8190, (2021).

Impacts of U.S. Streams on the Lipidome of Zebrafish Liver Cells. This dataset is associated with the following publication: Zhen, H., Q. Teng, J. Mosley, T. Collette, Y. Yue, P. Bradley, and D. Ekman. Untargeted Lipidomics for Determining Cellular and Subcellular Responses in Zebrafish (Danio rerio) Liver Cells Following Exposure to Complex Mixtures in U.S. Streams. ENVIRONMENTAL SCIENCE & TECHNOLOGY. American Chemical Society, Washington, DC, USA, 55(12): 8180–8190, (2021).

Retention time and abundances from GC/MS analysis of amphibian livers exposed to pesticide, predation or combined stresses. This dataset is associated with the following publication: Henderson, M., M.N. Snyder, D. Glinski, and T. Purucker. Differentiating metabolomic responses of amphibians to multiple stressors. SCIENCE OF THE TOTAL ENVIRONMENT. Elsevier BV, AMSTERDAM, NETHERLANDS, 838(3): 155666, (2022).

Retention time and abundances from GC/MS analysis of amphibian livers exposed to pesticide, predation or combined stresses. This dataset is associated with the following publication: Henderson, M., M.N. Snyder, D. Glinski, and T. Purucker. Differentiating metabolomic responses of amphibians to multiple stressors. SCIENCE OF THE TOTAL ENVIRONMENT. Elsevier BV, AMSTERDAM, NETHERLANDS, 838(3): 155666, (2022).

This file contains data used to generate figures shown in Catron et al. Characterization of host toxicity and microbiota disruption in larval zebrafish following developmental exposure to BPA and BPA alternatives. This dataset is associated with the following publication: Catron, T., S. Keely, N. Brinkman, T. Zurlinden, C. Wood, J. Wright, D. Phelps, E. Wheaton, A. Kvasnicka, S. Gaballah, R. Lamendella, and T. Tal. Host Developmental Toxicity of BPA and BPA Alternatives Is Inversely Related to Microbiota Disruption in Zebrafish. TOXICOLOGICAL SCIENCES. Society of Toxicology, RESTON, VA, 167(2): 468-483, (2019).

This dataset contains 60-min locomotor response data for all control, chemical and particulate-extract-treated zebrafish. This dataset is associated with the following publication: Stevens, J., S. Padilla, D. DeMarini, D. Hunter, K. Martin, L. Thompson, I. Gilmour, M. Hazari, and A. Farraj. Zebrafish Locomotor Responses Reveal Irritant Effects of Fine Particulate Matter Extracts and a Role for TRPA1. TOXICOLOGICAL SCIENCES. Society of Toxicology, RESTON, VA, 161(2): 290-299, (2018).