Serum PFAS concentrations, pup weights, liver histopathology measurements, lipid panels, fasting insulin measurements. This dataset is not publicly accessible because: Data is the property of NIH. It can be accessed through the following means: Contact Suzanne Fenton for data (suzane.fenton@nih.gov). Format: Data stored in excel database format. This dataset is associated with the following publication: Cope, H.A., B.E. Blake, C. Love, J. McCord, S.A. Elmore, J.B. Harvey, V.A. Chappell, and S.E. Fenton. Latent, sex-specific metabolic health effects in CD-1 mouse offspring exposed to PFOA or HFPO-DA (GenX) during gestation. Emerging Contaminants. Elsevier B.V., Amsterdam, NETHERLANDS, 7: 219-235, (2021).

All data tables are available in the publication and uploaded onto ScienceHub. This dataset is associated with the following publication: Bangma, J., T.C. Guillette, M. Strynar, A. Lindstrom, J. McCord, D. Jenkins-Hill, C. Lau, N. Chernoff, and J. Lang. A rapid assessment bioaccumulation screening (RABS) study design for emerging per-and polyfluoroalkyl substances in mice exposed to industrially impacted surface water. CHEMOSPHERE. Elsevier Science Ltd, New York, NY, USA, 308(1): 136159, (2022).

The data presented in this data file is a product of a draft ASTM standard. The dataset contains FTOH concentrations measured in thermal desorption tube stability evaluation. It is also published in J Chromatogr. A, 1705 (2023) 464204. This dataset is associated with the following publication: Liu, X., and Z. Robbins. ASTM Standard Test Method for Determination of Fluorotelomer Alcohols in Air by Thermal Desorption - Gas Chromatography Triple Quadrupole Tandem Mass Spectrometry. U.S. EPA Office of Research and Development, Washington, DC, USA, 2023.

Dataset for A Comparison of In Vitro Points of Departure with Human Biomonitoring Levels for Per- and Polyfluoroalkyl Substances (PFAS), to be published by Environmental Health Perspectives (EHP). This dataset is associated with the following publication: Judson, R., D. Smith, M. Devito, J. Wambaugh, B. Wetmore, K. Friedman, G. Patlewicz, R. Thomas, R. Sayre, J. Olker, S. Degitz, S. Padilla, J. Harrill, T. Shafer, and K. Carstens. A Comparison of In Vitro Points of Departure with Human Blood Levels for Per- and Polyfluoroalkyl Substances (PFAS) (Toxics). Toxics. MDPI, Basel, SWITZERLAND, 12(4): 271, (2024).

This research effort describes a systematic evidence map of relevant health literature for ~150 Per and Polyfluoroalkyl Substances (PFAS). The literature search results, screening and tagging results, and data extractions are all available via download from the provided URLS from HERO, HAWC, and Tableau respectively. In addition, supplemental data files that capture the literature search synonyms, strings, and results are available in the excel file. The word file includes additional information about the results from searching gray literature and other resources consulted, as well as appendixes of human and animal design considerations. The full manuscript contains additional URLs and data with interactive visualizations. This dataset is associated with the following publication: Carlson, L., M. Angrish, A. Shirke, E. Radke-Farabaugh, B. Schulz, A. Kraft, R. Judson, G. Patlewicz, R. Blain, C. Lin, N. Vetter, C. Lemeris, P. Hartman, H. Hubbard, X. Arzuaga, A. Davis, L. Dishaw, I. Druwe, H. Hollinger, R. Jones, J. Kaiser, L. Lizarraga, P. Noyes, M. Taylor, A. Shapiro, A. Williams, and K. Thayer. Systematic Evidence Map for Over One Hundred and Fifty Per- and Polyfluoroalkyl Substances (PFAS). ENVIRONMENTAL HEALTH PERSPECTIVES. National Institute of Environmental Health Sciences (NIEHS), Research Triangle Park, NC, USA, 130(5): 1-20, (2022).

We used systematic evidence map methods to summarize the available epidemiological and animal bioassay evidence for an expanded set of ~15,000 PFAS that were identified as PFAS by EPA's Center for Computational Toxicology and Exposure (CCTE). This work is a continuation of our previous 2022 and 2024 SEMs that inventoried evidence on a separate set of ~500 PFAS (Carlson et al, 2022, https://doi.org/10.1289/EHP10343; Radke et al, 2022, https://doi.org/10.1289/EHP11185; Carlson et al., 2024; https://doi.org/10.1289/EHP14191) and a 2023 evidence map on an additional 345 PFAS (Shirke et al. 2024, https://doi.org/10.1289/EHP13423 ). The comprehensive PFAS dashboard includes evidence identified from our past SEMs and completed US EPA assessments. This dataset is associated with the following publication: Shirke, A., E. Radke, R. Jones, B. Allen, C. Lin, A. Ross, N. Vetter, C. Lemeris, p. hartman, S. Eftim, A. Varghese, R. Blain, H. Hubbard, A. Williams, K. Thayer, and L. Carlson. Systematic Evidence Map for the Per- and Polyfluoroalkyl Substances (PFAS) Universe. ENVIRONMENTAL HEALTH PERSPECTIVES. National Institute of Environmental Health Sciences (NIEHS), Research Triangle Park, NC, USA, 0(0): 1-45, (2025).

General aggregate PFOS and PFOA exposure estimates are based on reported summary statistics from concentration studies by media, i.e. into indoor air, outdoor air, food, water, dust and soil, and published contact rates. These values were entered into a first-order PK model to estimate PFOS and PFOA blood serum concentrations. which were then compared measured concentrations reported by the 2013-2014 National Health and Nutrition Examination Survey (NHANES) measured concentrations. These methods are an expansion of the process taken by two previous studies, which predicted body burden from aggregate route intakes for PFOA and for PFOS, respectively. This dataset is associated with the following publication: East, A., P. Egeghy, E. Hubal, R. Slover, and D. Vallero. Computational estimates of daily aggregate exposure to PFOA/PFOS from 2011 to 2017 using a basic intake model. Journal of Exposure Science and Environmental Epidemiology. Nature Publishing Group, London, UK, 33: 56-68, (2023).

Data for "Smeltz MG, Clifton MS, Henderson WM, McMillan L, Wetmore BA. Targeted Per- and Polyfluoroalkyl substances (PFAS) assessments for high throughput screening: Analytical and testing considerations to inform a PFAS stock quality evaluation framework. Toxicol Appl Pharmacol. 2023 Jan 15;459:116355. doi: 10.1016/j.taap.2022.116355. Epub 2022 Dec 16. PMID: 36535553". This dataset is associated with the following publication: Smeltz, M., M. Clifton, W. Henderson, L. McMillan, and B. Wetmore. Targeted Per- and Polyfluoroalkyl substances (PFAS) assessments for high throughput screening: Analytical and testing considerations to inform a PFAS stock quality evaluation framework. TOXICOLOGY AND APPLIED PHARMACOLOGY. Academic Press Incorporated, Orlando, FL, USA, 459: 116355, (2023).

Results of single concentration and concentration response testing of 165 PFAS samples from the USEPA ToxCast chemical library in nine (9) thyroid relevant assays. Chemicals were first screened in single concentration ('Single Concentration' tab) and then those chemicals with 50% or greater activity were further tested in concentration-response mode ('Concentration Response' tab). This dataset is associated with the following publication: Degitz, S., J. Olker, J. Denny, P. Degoey, P. Hartig, M. Cardon, S. Eytcheson, J. Haselman, S. Mayasich, and M. Hornung. In vitro screening of per- and polyfluorinated substances (PFAS) for interference with seven thyroid hormone system targets across nine assays. TOXICOLOGY IN VITRO. Elsevier Science Ltd, New York, NY, USA, 95: 105762, (2024).