Compositions comprising a taxane having a carbamoyloxy substituent at C(10), a hydroxy substituent at C(7), and a range of C(2), C(9), C(14), and side chain substituents.

This invention provides new benzoxazepine compounds represented by the formula: Äwherein R stands for a lower alkyl group optionally substituted with a hydroxyl group, X stands for an optionally substituted carbamoyl group or an optionally substituted heterocyclic group having a deprotonatable hydrogen atom, R1 stands for a lower alkyl group and W stands for a halogen atomÜ having activities of lowering chlesterol-level and lowering trigluceride-level, and being useful for prophylaxis and therapy of hyperlipidemia.

A composition comprising a basic drug, a drug which forms a zwitterion, or a salt of either entity, admixed with a polymer selected from hydroxypropylmethylcellulose acetate succinate (HPMCAS), cellulose acetate trimellitate (CAT), cellulose acetate phthalate (CAP), hydroxypropylcellulose acetate phthalate (HPCAP), hydroxypropylmethyl-cellulose acetate phthalate (HPMCAP), and methylcellulose acetate phthalate (MCAP). The compositions having improved solubility, hence bioavailability, in the small intestine; Processes for testing such compositions, and methods of using such compositions. The compositions comprise the basic drug, zwitterion, or salt and one or more of the aforementioned polymers. The invention further relates to a method for increasing the bioavailability of a basic or a zwitterionic drug comprising co-administering the basic drug, the zwitterionic drug, or the salt, with one or more of the aforementioned polymers.

The present invention provides compounds of formula I that are useful as potent and selective inhibitors of 11-beta hydroxysteroid dehydrogenase 1. The present invention further provides a pharmaceutical composition which comprises a compound of Formula I, or a pharmaceutical salt thereof, and a pharmaceutically acceptable carrier, diluent, or excipient. In addition, the present invention provides compositions comprising compounds of formula I for the treatment of metabolic syndrome, diabetes, hyperglycemia, obesity, hypertension, hyperlipidemia, other symptoms associated with hyperglycemia, and related disorders. Formula (I) wherein, R0 is (II), or (III) G1 is methylene or ethylene; L is a divalent linking group selected from —(C1-C4) alkylene-, —S—, —CH(OH)—, or —O—; A is methylene, —S—, —O—, or —NH—; and the other substituents are as defined in the claims.

1,2,4-Triazol-1-yl-methyl-carbinols of the formula in which Ar is optionally substituted aryl, and Het is optionally substituted heteroaryl with at least 2 different hetero-atoms, or addition products thereof with plant-tolerated acids or metal salts, which possess fungicidal activity.

Chemical patent from PubChem database. Patent Number: AT-E400543-T1. Title: Process for Preparing Therapeutic Agents. Filing Date: 2006-07-08. Inventors: Yamamoto, Hiroshi, Schmidt, Hans. Abstract: A process for preparing therapeutic agents is described, involving multiple synthetic steps with optimized reaction conditions. The process enables la... IPC Classifications: C12N, C12P, A61K. This patent covers 38 claims related to 4 chemical compounds. Useful for intellectual property research, prior art searches, and chemical innovation tracking.

Chemical patent from PubChem database. Patent Number: AT-E401096-T1. Title: Combinatorial Chemistry Method. Filing Date: 2006-06-26. Inventors: Kim, Young-Soo, Taylor, Elizabeth. Abstract: A combinatorial chemistry method for generating libraries of chemical compounds is disclosed, enabling rapid identification of lead compounds for drug... IPC Classifications: B01J, C07C, C07D. This patent covers 47 claims related to 4 chemical compounds. Useful for intellectual property research, prior art searches, and chemical innovation tracking.

The present invention provides compounds of formula I that are useful as potent and selective inhibitors of 11-beta hydroxysteroid dehydrogenase 1. The present invention further provides a pharmaceutical composition which comprises a compound of Formula I, or a pharmaceutical salt thereof, and a pharmaceutically acceptable carrier, diluent, or excipient. In addition, the present invention compositions containing these compounds for the treatment of metabolic syndrome, diabetes, hyperglycemia obesity, hypertension, hyperlipidemia, other symptoms associated with hyperglycemia, and related disorders. Formula I wherein G1 is methylene or ethylene; L is -(C1-C4)alkylene-, -S-, -CH(OH)-, or -O-; R0 is Formula II or Formula III and the other substituents are as defined in the claims.

The present invention provides compounds of formula I that are useful as potent and selective inhibitors of 11-beta hydroxysteroid dehydrogenase 1. The present invention further provides a pharmaceutical composition which comprises a compound of Formula I, or a pharmaceutical salt thereof, and a pharmaceutically acceptable carrier, diluent, or excipient. In addition, the present invention compositions containing these compounds for the treatment of metabolic syndrome, diabetes, hyperglycemia obesity, hypertension, hyperlipidemia, other symptoms associated with hyperglycemia, and related disorders. Formula I wherein G1 is methylene or ethylene; L is -(C1-C4)alkylene-, -S-, -CH(OH)-, or -O-; R0 is Formula II or Formula III and the other substituents are as defined in the claims.

Chemical patent from PubChem database. Patent Number: AT-E40106-T1. Title: Method of Treatment Using Chemical Compounds. Filing Date: 2006-06-16. Inventors: Martinez, Carlos, Thompson, Emily. Abstract: Methods for treating diseases using specific chemical compounds are provided, including dosing regimens and combination therapies for enhanced therape... IPC Classifications: C07D, C07F, A61K. This patent covers 34 claims related to 4 chemical compounds. Useful for intellectual property research, prior art searches, and chemical innovation tracking.