This dataset includes surface underway, chemical, meteorological and physical data collected during R/V Cape Hatteras cruises in the US South East Coastal Waters and North Atlantic Ocean from 2005-01-05 to 2006-05-27. These data include partial pressure (or fugacity) of carbon dioxide - water, sea surface salinity, sea surface water temperature and barometric pressure. The instruments used to collect these data include Carbon dioxide (CO2) gas analyzer and shower head chamber equilibrator for autonomous carbon dioxide (CO2) measurement. These data were collected by Wei-Jun Cai of University of Delaware as part of the South Atlantic Bight (SAB) dataset. The survey was carried out on six cruises: 5-16 January 2005, 19-30 March 2005, 27 July - 5 August 2005, 7-17 October 2005, 16-21 December 2005, and 17-27 May 2006. In all of the sampling cruises except for the one in December 2005, the research vessel transected the whole SAB from coastline to about 500 m water depth. The survey focused on 5 cross-shelf transects that are named E-, D-, C-, B-, and A-transects respectively from north to south (Figure 1). In December 2005 the ship still transected the whole SAB, but did not cover D- and B-transects and did not go beyond the 200 m isobath. Sea level pressure was recorded using an on board R.M. Young® barometric pressure sensor. Sea surface temperature (SST) and salinity were recorded continuously with an on-board SeaBird® flow through thermosalinography. Surface water and atmospheric xCO2 were also measured underway during all cruises.