The dataset contains a list of cardiac and vascular biomarkers that were obtained on each day a participant visited the EPA Human Studies Facility. It also contains ozone concentrations on those days, which are publicly available on the EPA AirNow website. This dataset is not publicly accessible because: The dataset pertains to human research. It can be accessed through the following means: Requests to access data should be sent to Robert Devlin at devlin.robert@epa.gov. Format: The metadata are in the form of spreadsheets with health endpoints listed in columns and each human participant listed as a row. Similar spreadsheets contain exposure information in columns and participants in rows. This dataset is associated with the following publication: Mirowsky, J., M. Carraway, R. Dhingra, H. Tong, L. Neas, D. Diaz-Sanchez, W. Cascio, M. Case, J. Crooks, E. Hauser, E. Dowdy, W. Krause, and R. Devlin. Ozone exposure is associated with acute changes in inflammation, fibrinolysis, and endothelial cell function in coronary artery disease patients. ENVIRONMENTAL HEALTH. Academic Press Incorporated, Orlando, FL, USA, 16: 126, (2017).

Dataset contains a list of metabolites, their fold change after ozone exposure and a p value for that change. This dataset is not publicly accessible because: EPA cannot release personally identifiable information regarding living individuals, according to the Privacy Act and the Freedom of Information Act (FOIA). This dataset contains information about human research subjects. Because there is potential to identify individual participants and disclose personal information, either alone or in combination with other datasets, individual level data are not appropriate to post for public access. Restricted access may be granted to authorized persons by contacting the party listed. It can be accessed through the following means: This dataset can be accessed by contacting Dr. Robert Devlin (devlin.rober@epa.gov). Format: The dataset was sent to us by the company (Metabolon) that did the metabolite analysis, including the statistical analysis). It is an excel spreadsheet that contains a row for each of the metabolites that were identified, fold changes in each metabolite after air and ozone exposure (and the p value of the ozone-induced change), and the pathway and superpathway to which each metabolite belongs. This dataset is associated with the following publication: Cheng, W., K. Duncan, A. Ghio, C. Ward-Caviness, E. Karoly, D. Diaz-Sanchez, R. Conolly, and R. Devlin. Changes in metabolites present in lung-lining fluid following exposure to humans to ozone. TOXICOLOGICAL SCIENCES. Society of Toxicology, RESTON, VA, 163(2): 430-439, (2018).

Dataset contains a list of metabolites, their fold change after ozone exposure and a p value for that change. This dataset is not publicly accessible because: EPA cannot release personally identifiable information regarding living individuals, according to the Privacy Act and the Freedom of Information Act (FOIA). This dataset contains information about human research subjects. Because there is potential to identify individual participants and disclose personal information, either alone or in combination with other datasets, individual level data are not appropriate to post for public access. Restricted access may be granted to authorized persons by contacting the party listed. It can be accessed through the following means: This dataset can be accessed by contacting Dr. Robert Devlin (devlin.rober@epa.gov). Format: The dataset was sent to us by the company (Metabolon) that did the metabolite analysis, including the statistical analysis). It is an excel spreadsheet that contains a row for each of the metabolites that were identified, fold changes in each metabolite after air and ozone exposure (and the p value of the ozone-induced change), and the pathway and superpathway to which each metabolite belongs. This dataset is associated with the following publication: Cheng, W., K. Duncan, A. Ghio, C. Ward-Caviness, E. Karoly, D. Diaz-Sanchez, R. Conolly, and R. Devlin. Changes in metabolites present in lung-lining fluid following exposure to humans to ozone. TOXICOLOGICAL SCIENCES. Society of Toxicology, RESTON, VA, 163(2): 430-439, (2018).

This dataset includes raw data used to generate figures for the manuscript describing the effects of noise and ozone on cardiovascular function in rats. This dataset is associated with the following publication: Hazari, M., K. Phillips, K. Stratford, A.M. Khan, L. Thompson, W. Oshiro, G. Hudson, D. Herr, and A. Farraj. Exposure to intermittent noise exacerbates the cardiovascular response of Wistar-Kyoto Rats to Ozone Inhalation and Arrhythmogenic Challenge. Cardiovascular Toxicology. Humana Press Incorporated, Totowa, NJ, USA, 21(4): 336-348, (2021).

This dataset includes raw data used to generate figures for the manuscript describing the effects of noise and ozone on cardiovascular function in rats. This dataset is associated with the following publication: Hazari, M., K. Phillips, K. Stratford, A.M. Khan, L. Thompson, W. Oshiro, G. Hudson, D. Herr, and A. Farraj. Exposure to intermittent noise exacerbates the cardiovascular response of Wistar-Kyoto Rats to Ozone Inhalation and Arrhythmogenic Challenge. Cardiovascular Toxicology. Humana Press Incorporated, Totowa, NJ, USA, 21(4): 336-348, (2021).

This dataset provides modeled predictions of ozone levels from the EPA's Downscaler model. Data are at the census tract level for 2001-2005. These data are used by the CDC's National Environmental Public Health Tracking Network to generate air quality measures. Census tract-level datasets contain estimates of the mean predicted concentration and associated standard error. Please refer to the metadata attachment for more information. Learn more about outdoor air quality on the Tracking Network's website: https://ephtracking.cdc.gov/showAirLanding.action. By using these data, you signify your agreement to comply with the following requirements: 1. Use the data for statistical reporting and analysis only. 2. Do not attempt to learn the identity of any person included in the data and do not combine these data with other data for the purpose of matching records to identify individuals. 3. Do not disclose of or make use of the identity of any person or establishment discovered inadvertently and report the discovery to: trackingsupport@cdc.gov. 4. Do not imply or state, either in written or oral form, that interpretations based on the data are those of the original data sources and CDC unless the data user and data source are formally collaborating. 5. Acknowledge, in all reports or presentations based on these data, the original source of the data and CDC. 6. Suggested citation: Centers for Disease Control and Prevention. National Environmental Public Health Tracking Network. Web. Accessed: insert date. www.cdc.gov/ephtracking.

This dataset provides modeled predictions of ozone levels from the EPA's Downscaler model. Data are at the census tract level for 2001-2005. These data are used by the CDC's National Environmental Public Health Tracking Network to generate air quality measures. Census tract-level datasets contain estimates of the mean predicted concentration and associated standard error. Please refer to the metadata attachment for more information. Learn more about outdoor air quality on the Tracking Network's website: https://ephtracking.cdc.gov/showAirLanding.action. By using these data, you signify your agreement to comply with the following requirements: 1. Use the data for statistical reporting and analysis only. 2. Do not attempt to learn the identity of any person included in the data and do not combine these data with other data for the purpose of matching records to identify individuals. 3. Do not disclose of or make use of the identity of any person or establishment discovered inadvertently and report the discovery to: trackingsupport@cdc.gov. 4. Do not imply or state, either in written or oral form, that interpretations based on the data are those of the original data sources and CDC unless the data user and data source are formally collaborating. 5. Acknowledge, in all reports or presentations based on these data, the original source of the data and CDC. 6. Suggested citation: Centers for Disease Control and Prevention. National Environmental Public Health Tracking Network. Web. Accessed: insert date. www.cdc.gov/ephtracking.

This dataset provides modeled predictions of ozone levels from the EPA's Downscaler model. Data are at the census tract level for 2006-2010. These data are used by the CDC's National Environmental Public Health Tracking Network to generate air quality measures. Census tract-level datasets contain estimates of the mean predicted concentration and associated standard error. Please refer to the metadata attachment for more information. Learn more about outdoor air quality on the Tracking Network's website: https://ephtracking.cdc.gov/showAirLanding.action. By using these data, you signify your agreement to comply with the following requirements: 1. Use the data for statistical reporting and analysis only. 2. Do not attempt to learn the identity of any person included in the data and do not combine these data with other data for the purpose of matching records to identify individuals. 3. Do not disclose of or make use of the identity of any person or establishment discovered inadvertently and report the discovery to: trackingsupport@cdc.gov. 4. Do not imply or state, either in written or oral form, that interpretations based on the data are those of the original data sources and CDC unless the data user and data source are formally collaborating. 5. Acknowledge, in all reports or presentations based on these data, the original source of the data and CDC. 6. Suggested citation: Centers for Disease Control and Prevention. National Environmental Public Health Tracking Network. Web. Accessed: insert date. www.cdc.gov/ephtracking.

This dataset provides modeled predictions of ozone levels from the EPA's Downscaler model. Data are at the census tract level for 2011-2014. These data are used by the CDC's National Environmental Public Health Tracking Network to generate air quality measures. Census tract-level datasets contain estimates of the mean predicted concentration and associated standard error. Please refer to the metadata attachment for more information. Learn more about outdoor air quality on the Tracking Network's website: https://ephtracking.cdc.gov/showAirLanding.action. By using these data, you signify your agreement to comply with the following requirements: 1. Use the data for statistical reporting and analysis only. 2. Do not attempt to learn the identity of any person included in the data and do not combine these data with other data for the purpose of matching records to identify individuals. 3. Do not disclose of or make use of the identity of any person or establishment discovered inadvertently and report the discovery to: trackingsupport@cdc.gov. 4. Do not imply or state, either in written or oral form, that interpretations based on the data are those of the original data sources and CDC unless the data user and data source are formally collaborating.

This dataset provides modeled predictions of ozone levels from the EPA's Downscaler model. Data are at the census tract level for 2001-2005. These data are used by the CDC's National Environmental Public Health Tracking Network to generate air quality measures. Census tract-level datasets contain estimates of the mean predicted concentration and associated standard error. Please refer to the metadata attachment for more information. Learn more about outdoor air quality on the Tracking Network's website: https://ephtracking.cdc.gov/showAirLanding.action. By using these data, you signify your agreement to comply with the following requirements: 1. Use the data for statistical reporting and analysis only. 2. Do not attempt to learn the identity of any person included in the data and do not combine these data with other data for the purpose of matching records to identify individuals. 3. Do not disclose of or make use of the identity of any person or establishment discovered inadvertently and report the discovery to: trackingsupport@cdc.gov. 4. Do not imply or state, either in written or oral form, that interpretations based on the data are those of the original data sources and CDC unless the data user and data source are formally collaborating. 5. Acknowledge, in all reports or presentations based on these data, the original source of the data and CDC. 6. Suggested citation: Centers for Disease Control and Prevention. National Environmental Public Health Tracking Network. Web. Accessed: insert date. www.cdc.gov/ephtracking.