Integrative computational approaches to inform relative bioaccumulation potential of per- and polyfluoroalkyl substances (PFAS) across species
공공데이터포털
Datasets included in the entry are Results from the US Environmental Protection Agency Sequence Alignment to Predict Across Species Susceptibility (SeqAPASS) tool and from the molecular modeling workflow that includes molecular docking and molecular dynamic simulations. All data that are represented in the figures, tables, and supplemental materials associated with this manuscript are included in this dataset entry. This dataset is associated with the following publication: Cheng, W., J. Doering, C. LaLone, and C. Ng. Integrative computational approaches to inform relative bioaccumulation potential of per- and polyfluoroalkyl substances (PFAS) across species. TOXICOLOGICAL SCIENCES. Society of Toxicology, RESTON, VA, 180(2): 212-223, (2021).
Integrative computational approaches to inform relative bioaccumulation potential of per- and polyfluoroalkyl substances (PFAS) across species
공공데이터포털
Datasets included in the entry are Results from the US Environmental Protection Agency Sequence Alignment to Predict Across Species Susceptibility (SeqAPASS) tool and from the molecular modeling workflow that includes molecular docking and molecular dynamic simulations. All data that are represented in the figures, tables, and supplemental materials associated with this manuscript are included in this dataset entry. This dataset is associated with the following publication: Cheng, W., J. Doering, C. LaLone, and C. Ng. Integrative computational approaches to inform relative bioaccumulation potential of per- and polyfluoroalkyl substances (PFAS) across species. TOXICOLOGICAL SCIENCES. Society of Toxicology, RESTON, VA, 180(2): 212-223, (2021).
Liver steatosis study PFAA treated mouse gene array data
공공데이터포털
This file contains a link for Gene Expression Omnibus and the GSE designations for the publicly available gene expression data used in the study and reflected in Figures 6 and 7 for the Das et al., 2016 paper. This dataset is associated with the following publication: Das, K., C. Wood, M. Lin, A.A. Starkov, C. Lau, K.B. Wallace, C. Corton, and B. Abbott. Perfluoroalky acids-induced liver steatosis: Effects on genes controlling lipid homeostasis. TOXICOLOGY. Elsevier Science Ltd, New York, NY, USA, 378: 32-52, (2017).
Per- and Polyfluoroalkyl Substances (PFAS) in mixtures show additive effects on transcriptomic points of departure in human liver spheroids
공공데이터포털
Data for "Addicks GC, Rowan-Carroll A, Reardon A, Leingartner K, Williams A, Meier MJ, Moffat I, Carrier R, Lorusso L, Wetmore BA, Yauk C, Atlas E. Per- and Polyfluoroalkyl Substances (PFAS) in mixtures show additive effects on transcriptomic points of departure in human liver spheroids. Toxicol Sci. 2023 May 17:kfad044. doi: 10.1093/toxsci/kfad044. Epub ahead of print. PMID: 37195416.". This dataset is associated with the following publication: Addicks, G., A. Rowan-Carroll, A. Reardon, K. Leingartner, A. Williams, M. Meier, I. Moffat, R. Carrier, L. Lorusso, B. Wetmore, C. Yauk, and E. Atlas. Per- and polyfluoroalkyl substances (PFAS) in mixtures show additive effects on transcriptomic points of departure in human liver spheroids. TOXICOLOGICAL SCIENCES. Society of Toxicology, RESTON, VA, 194(1): 38-52, (2023).
Per- and Polyfluoroalkyl Substances (PFAS) in mixtures show additive effects on transcriptomic points of departure in human liver spheroids
공공데이터포털
Data for "Addicks GC, Rowan-Carroll A, Reardon A, Leingartner K, Williams A, Meier MJ, Moffat I, Carrier R, Lorusso L, Wetmore BA, Yauk C, Atlas E. Per- and Polyfluoroalkyl Substances (PFAS) in mixtures show additive effects on transcriptomic points of departure in human liver spheroids. Toxicol Sci. 2023 May 17:kfad044. doi: 10.1093/toxsci/kfad044. Epub ahead of print. PMID: 37195416.". This dataset is associated with the following publication: Addicks, G., A. Rowan-Carroll, A. Reardon, K. Leingartner, A. Williams, M. Meier, I. Moffat, R. Carrier, L. Lorusso, B. Wetmore, C. Yauk, and E. Atlas. Per- and polyfluoroalkyl substances (PFAS) in mixtures show additive effects on transcriptomic points of departure in human liver spheroids. TOXICOLOGICAL SCIENCES. Society of Toxicology, RESTON, VA, 194(1): 38-52, (2023).
Data from: Understanding genetic architecture overcomes tradeoffs between seed quality and insect resistance
공공데이터포털
,Phenotypes_raw_sunflower_pericarp.xlsx,Six tabs containing phenotypic data for sunflower pericarp, oil content, and banded sunflower moth damage measured in recombinant inbred lines (RIL) and sunflower association mapping (SAM) population. The first 3 tabs contain phenotypes for RIL population and the last 3 tabs contain phenotypes from the SAM population.,RIL_strength_thickness: ‘geno’ contains the names of the RIL, ‘year’ is the year evaluated, ‘rep’ is the repetition, ‘plant’ is the plant sampled, ‘pericarp_strength’ and ‘pericarp_thickness’ are the traits measured.,RIL_oil: ‘geno’ contains the names of the RIL, ‘year’ is the year evaluated, ‘rep’ is the repetition, and ‘oil’ is the measured oil content.,RIL_BSM: ‘geno’ contains the names of the RIL, ‘year’ is the year evaluated, ‘seed’ the number of seed imaged, ‘empty’ the number of seeds with no achene, ‘moth_damage’ the number of seed with moth damage, and ‘percent_moth_damaged’ is the percentage of non-empty seed with moth damage.,SAM_thickness_2016: ‘SAM’ contains the name of the SAM line. The other column names denote the head and achene number from which pericarp thickness below was measured in 2016. For example, ‘head1_achene1’ means the first head and first achene from the first head, and ‘head1_achene2’ is the second achene sampled from the first head.,SAM_thickness_2015: ‘SAM’ contains the name of the SAM line. The other column names denote the head and achene number from which pericarp thickness below was measured in 2015. For example, ‘head1_achene1’ means the first head and first achene from the first head, and ‘head1_achene2’ is the second achene sampled from the first head.,SAM_oil: ‘SAM’ contains the name of the SAM line, ‘year’ is the year evaluated, ‘plant’ is the plant sampled and ‘oil’ is the measured oil content.,HA467xPI170415 Starting Genotypes,SNP prior to filtering for the RIL population developed from HA467 × PI170415. Row names are SNP names and contain chromosome number and physical position. Column names contain the RIL names. Last two columns contain parental genotypes. Homozygotes are coded as 0|0 and 1|1 and heterozygous calls as 1|0 or 0|1.,Oil_linkageMap.xls & Pericarp_linkageMap.xls,Input for IciMapping for oil content and pericarp traits measured in the RIL population. The purpose of including these files is to list the SNP used in the linkage map. This information can be found in Chromosome and Genotype tabs. An explanation of the other tabs can be found in IciMapping manual: https://isbreedingen.caas.cn/software/qtllcimapping/294607.htm *This work used resources of the Center for Computationally Assisted Science and Technology (CCAST) at North Dakota State University, which were made possible in part by NSF MRI Award No. 2019077.,
Nichols et al PMSF ScienceHub entry
공공데이터포털
This dataset describes the results of a set of experiments, the goal of which was to evaluate the effects of protease inhibitors on the trout liver S9 substrate depletion assay. The presented data show that addition of phenylmethylsulfonyl fluoride (PMSF), a serine protease inhibitor, substantially increases the working lifetime of the trout S9 assay, resulting in improved detection of low intrinsic clearance rates. These findings substantially increase the utility of the trout S9 assay and may have broad implications for its use to support chemical bioaccumulation assessments. This dataset is associated with the following publication: Nichols, J., A. Hoffman, J. Swintek, S. Droge, and P. Fitzsimmons. Addition of phenylmethylsulfonyl fluoride (PMSF) substantially increases the working lifetime of the trout liver S9 substrate depletion assay resulting in improved detection of low intrinsic clearance rates. ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY. Society of Environmental Toxicology and Chemistry, Pensacola, FL, USA, 40(1): 148-161, (2021).
Nichols et al PMSF ScienceHub entry
공공데이터포털
This dataset describes the results of a set of experiments, the goal of which was to evaluate the effects of protease inhibitors on the trout liver S9 substrate depletion assay. The presented data show that addition of phenylmethylsulfonyl fluoride (PMSF), a serine protease inhibitor, substantially increases the working lifetime of the trout S9 assay, resulting in improved detection of low intrinsic clearance rates. These findings substantially increase the utility of the trout S9 assay and may have broad implications for its use to support chemical bioaccumulation assessments. This dataset is associated with the following publication: Nichols, J., A. Hoffman, J. Swintek, S. Droge, and P. Fitzsimmons. Addition of phenylmethylsulfonyl fluoride (PMSF) substantially increases the working lifetime of the trout liver S9 substrate depletion assay resulting in improved detection of low intrinsic clearance rates. ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY. Society of Environmental Toxicology and Chemistry, Pensacola, FL, USA, 40(1): 148-161, (2021).
U.S. Domestic Cats as Sentinels for Perfluoroalkyl Substances
공공데이터포털
Legacy PFC work. Data stored in Phillip Bost’s Lab Notebook #1778; Room D286 (Lindstrom) RTP, NC EPA office. This dataset is associated with the following publication: Bost, P., M. Strynar, J. Reiner, J. Zweigenbaum, P. Secoura, A. Lindstrom, and J. Dye. U.S. Domestic Cats as Sentinels for Perfluoroalkyl Substances: Associations with Housing, Obesity and Chronic Disease. ENVIRONMENTAL SCIENCE & TECHNOLOGY. American Chemical Society, Washington, DC, USA, 151(0): 145-153, (2016).
U.S. Domestic Cats as Sentinels for Perfluoroalkyl Substances
공공데이터포털
Legacy PFC work. Data stored in Phillip Bost’s Lab Notebook #1778; Room D286 (Lindstrom) RTP, NC EPA office. This dataset is associated with the following publication: Bost, P., M. Strynar, J. Reiner, J. Zweigenbaum, P. Secoura, A. Lindstrom, and J. Dye. U.S. Domestic Cats as Sentinels for Perfluoroalkyl Substances: Associations with Housing, Obesity and Chronic Disease. ENVIRONMENTAL SCIENCE & TECHNOLOGY. American Chemical Society, Washington, DC, USA, 151(0): 145-153, (2016).