All summary data associated with manuscript figures and tables. This dataset is associated with the following publication: Conley, J., C. Lambright, N. Evans, M. Cardon, E. MedlockKakaley, V. Wilson, and E. Gray. A mixture of 15 phthalates and pesticides below individual chemical No Observed Adverse Effect Levels (NOAELs) produces reproductive tract malformations in the male rat. ENVIRONMENT INTERNATIONAL. Elsevier B.V., Amsterdam, NETHERLANDS, 156(106615): 1, (2021).

data set has a description of the information in the excell file and all the data used in the study. This dataset is associated with the following publication: Gray, E., J. Conley, C. Lambright, and J. Furr. In utero exposure to a mixture of the perfluoroalkylisopropyl pesticide pyrifluquinazon with dibutyl phthalate cumulatively disrupts male rat reproductive development via different mechanisms of action. TOXICOLOGICAL SCIENCES. Society of Toxicology, RESTON, VA, 188(2): 234-247, (2022).

METADATA OUTLINE SHEET 1 STUDY INFORMATION SHEET 2 RANDOM ASSISNMENT OF PREGNANT RATS TO TREATMENT GROUPS SHEER 3 MATERNAL WEIGHT AND WEIGHT GAIN DURING DOSING and fetal DATA RAW DATA RESULTS PREDICTIONS OF DOSE ADDITIVITY SHEET 4 TESTOSTERONE (T PROD) DATA RAW DATA SAS INPUT FILES TREATMENT EFFECTS SHEET 5 CUSTOM GENE (mRNA) SAS INPUT FILE WITH SAS STATEMENTS AND RQW DATA SHEET 6 RESULTS FROM STATISTICAL ANALYSIS OF CUSTOM ARRAY mRNA DATA CUSTOM ARRAY: LIST OF GENES AND GENE DESCRIPTIONS SHEET 7 PREDICTION MODELS OF TESTOSTERONE PRODUCTION REDUCTIONS AND REPRODUCTIVE EFFECTS OF IN UTERO PHTHALATE EXPOSURE SHEET 8 TREATMENT EFFECTS PREDICTED FROM THE TESTOSTERONE PREDICTION MODELS COMPARISON OF THE PREDICTED EFFECTS OF THE DBP+DINP MIXTURE WITH OBSERVED EFFECTS OF THE REFERENCE CHEMICAL (DBP) AT EQUIVALENT DOSES, ASSUMING DOSE ADDITIVITY. This dataset is associated with the following publication: Gray, L., C. Lambright, N. Evans, J. Ford, and J. Conley. Using Targeted Fetal Rat Testis Genomic and Endocrine Alterations to Predict the Effects of a Phthalate Mixture on the Male Reproductive Tract.. Current Research in Toxicology. Elsevier B.V., Amsterdam, NETHERLANDS, 7: 100180, (2024).

this file has the metadata sheet and the data used for the figures and tables in the PFQ vs BPC manuscript. This dataset is associated with the following publication: Gray, E., J. Furr, J. Conley, C. Lambright, N. Evans, M. Cardon, V. Wilson, P. Foster, and P. Hartig. A Conflicted Tale of Two Novel AR Antagonists In vitro and In vivo: Pyrifluquinazon versus Bisphenol C.. TOXICOLOGICAL SCIENCES. Society of Toxicology, RESTON, VA, 632-643, (2019).

RAW DATA, SAS FILES AND DATA MEANS. This dataset is associated with the following publication: Howdeshell, K., C. Rider, V. Wilson , J. Furr , C. Lambright , and E. Gray. Dose addition models based on biologically-relevant reductions in fetal testosterone accurately predict postnatal reproductive tract alterations by a phthalate mixture in rats. TOXICOLOGICAL SCIENCES. Society of Toxicology, 148(2): 488-502, (2015).

DATA FROM THE MANUSCRIPT BY BEVERLY ET AL 2019 FOR ALL TABLES AND FIGURES. This dataset is associated with the following publication: Beverly, B., J. Furr , C. Lambright , V. Wilson , B. MCINTYRE, P. FOSTER, G. TRAVLOS, and E. Gray. In utero exposure to Simvastatin reduces postnatal survival and permanently alters reproductive tract development in the CRL:CD(SD) male rat. TOXICOLOGY AND APPLIED PHARMACOLOGY. Academic Press Incorporated, Orlando, FL, USA, 112-123, (2019).

Dataset contains summary data (mean, standard error, sample size (n)) for all measured endpoints reported and depicted in the corresponding manuscript. This dataset is associated with the following publication: Conley, J., C. Lambright, N. Evans, M. Strynar, J. McCord, B. McIntyre, G. Travlos, M. Cardon, E. MedlockKakaley, P. Hartig, V. Wilson, and E. Gray. Adverse maternal, fetal, and postnatal effects of Hexafluoropropylene oxide dimer acid (GenX) from oral gestational exposure in Sprague Dawley rats. ENVIRONMENTAL HEALTH PERSPECTIVES. National Institute of Environmental Health Sciences (NIEHS), Research Triangle Park, NC, USA, 1-13, (2019).

Dataset includes all endpoint measurements from studies described in the manuscript and SAS code for statistical analyses of data. This dataset is associated with the following publication: Gray, L., C. Lambright, N. Evans, J. Ford, and J. Conley. Comparison of in utero phthalate exposure on fetal rat testis transcript and endocrine alterations with apical reproductive alterations in male rats. TOXICOLOGY AND APPLIED PHARMACOLOGY. Elsevier B.V., Amsterdam, NETHERLANDS, 502: 117447, (2025).

Background: Trends in male reproductive health have been reported for increased rates of testicular germ cell tumors, low semen quality, cryptorchidism, and hypospadias, which have been associated with prenatal environmental chemical exposure based on human and animal studies. Objective: In the present study we aimed to identify significant correlations between environmental chemicals, molecular targets, and adverse outcomes across a broad chemical landscape with emphasis on developmental toxicity of the male reproductive system. Methods: We used U.S. EPA’s animal study database (ToxRefDB) and a comprehensive literature analysis to identify 774 chemicals that have been evaluated for adverse effects on male reproductive parameters, and then used U.S. EPA’s in vitro high-throughput screening (HTS) database (ToxCastDB) to profile their bioactivity across approximately 800 molecular and cellular features. Results: A phenotypic hierarchy of testicular atrophy, sperm effects, tumors, and malformations, a composite resembling the human testicular dysgenesis syndrome (TDS) hypothesis, was observed in 281 chemicals. A subset of 54 chemicals with male developmental consequences had in vitro bioactivity on molecular targets that could be condensed into 156 gene annotations in a bipartite network. Conclusion: Computational modeling of available in vivo and in vitro data for chemicals that produce adverse effects on male reproductive end points revealed a phenotypic hierarchy across animal studies consistent with the human TDS hypothesis. We confirmed the known role of estrogen and androgen signaling pathways in rodent TDS, and importantly, broadened the list of molecular targets to include retinoic acid signaling, vascular remodeling proteins, G-protein coupled receptors (GPCRs), and cytochrome P450s. This dataset is associated with the following publication: Leung , M., J. Phuong , N. Baker , N. Sipes , G. Klinefelter , M. Martin , K. McLaurin, W. Setzer , S. Darney , R. Judson , and T. Knudsen. (ENVIRONMENTAL HEALTH PERSPECTIVES) Systems Toxicology of Male Reproductive Development: Profiling 774 Chemicals for Molecular Targets and Adverse Outcomes. ENVIRONMENTAL HEALTH PERSPECTIVES. National Institute of Environmental Health Sciences (NIEHS), Research Triangle Park, NC, USA, 1-47, (2015).

Dataset includes summary statistics (mean, standard error, sample size) for all endpoints measured and reported in the experiments described in the published manuscript. This dataset is associated with the following publication: Conley, J., C. Lambright, N. Evans, A. Farraj, J. Smoot, R. Grindstaff, D. Jenkins-Hill, J. McCord, E. Medlock Kakaley, A. Dixon, E. Hines, and L. Gray. Dose additive maternal and offspring effects of oral maternal exposure to a mixture of three PFAS (HFPO-DA, NBP2, PFOS) during pregnancy in the Sprague-Dawley rat. SCIENCE OF THE TOTAL ENVIRONMENT. Elsevier BV, AMSTERDAM, NETHERLANDS, 892: 164609, (2023).