The data contains location information, DNA methylation (transformed into epigenetic aging biomakers), dates of examination, demographics, disease diagnoses, and traffic-related air pollution exposures. It is stored as a series of data frames suitable for use in the R programming language. This dataset is not publicly accessible because: EPA cannot release personally identifiable information regarding living individuals, according to the Privacy Act and the Freedom of Information Act (FOIA). This dataset contains information about human research subjects. Because there is potential to identify individual participants and disclose personal information, either alone or in combination with other datasets, individual level data are not appropriate to post for public access. Restricted access may be granted to authorized persons by contacting the party listed. It can be accessed through the following means: This data can be accessed by contacting Dr. Cavin Ward-Caviness and describing your needs for the analysis, completing the necessary ethics trainings, and gaining approval on the appropriate IRB applications as well as by the CATHGEN Steering Committee. Format: The data contains location information, DNA methylation (transformed into epigenetic aging biomakers), dates of examination, demographics, disease diagnoses, and traffic-related air pollution exposures. It is stored as a series of data frames suitable for use in the R programming language. This dataset is associated with the following publication: Ward-Caviness, C., A. Russell, A. Weaver, E. Slawsky, R. Dhingra, L. Coulter Kwee, R. Jiang, L. Neas, D. Diaz-Sanchez, R. Devlin, W. Cascio, E. Hauser, S. Shah, W. Kraus, and K. Olden. Accelerated epigenetic age as a biomarker of cardiovascular sensitivity to traffic-related air pollution. Aging. Impact Journals, LLC, Orchard Park, NY, USA, 12(23): 24141-24155, (2020).

This dataset contains genome-wide DNA methylation data from the Illumina EPIC array as well as information on the exposure given (clean air, diesel, or ozone) at each time point. Demographic and anthropomorphic information on the participants in the study is also included within the dataset. This dataset is not publicly accessible because: EPA cannot release personally identifiable information regarding living individuals, according to the Privacy Act and the Freedom of Information Act (FOIA). This dataset contains information about human research subjects. Because there is potential to identify individual participants and disclose personal information, either alone or in combination with other datasets, individual level data are not appropriate to post for public access. Restricted access may be granted to authorized persons by contacting the party listed. It can be accessed through the following means: This data can be accessed by contacting the data owners. Access to the data requires an approved Institutional Review Board application from an appropriate institution. Format: This dataset include blood biomarker measurements (DNA methylation; Ilumina EPIC Methylation array) along with demographic and anthropomorphic information on participants. In addition there is data on which controlled exposure was received (clean air or diesel or ozone) and at which time points. This dataset is associated with the following publications: Cardenas, A., R. Fadadu, L. Van Der Laan, C. Ward-Caviness, L. Granger, D. Diaz-Sanchez, M. Bind, and R. Devlin. Controlled Human Exposures to Diesel Exhaust: A Human Epigenome-Wide Experiment of Target Bronchial Epithelial Cells. Environmental Epigenetics. Oxford University Press, Cary, NC, USA, 7(1): dvab003, (2021). Bind, M., D. Rubin, A. Cardenas, R. Dhingra, C. Ward-Caviness, Z. Liu, J. Mirowsky, J. Schwartz, B. Coull, D. Diazsanchez, and R. Devlin. HETEROGENEOUS OZONE EFFECTS ON DNA METHYLOME OF BRONCHIAL CELLS: OBSERVED IN A CROSSOVER STUDY. Scientific Reports. Nature Publishing Group, London, UK, 10(1): 15739, (2020).

This dataset contains genome-wide DNA methylation data from the Illumina EPIC array as well as information on the exposure given (clean air, diesel, or ozone) at each time point. Demographic and anthropomorphic information on the participants in the study is also included within the dataset. This dataset is not publicly accessible because: EPA cannot release personally identifiable information regarding living individuals, according to the Privacy Act and the Freedom of Information Act (FOIA). This dataset contains information about human research subjects. Because there is potential to identify individual participants and disclose personal information, either alone or in combination with other datasets, individual level data are not appropriate to post for public access. Restricted access may be granted to authorized persons by contacting the party listed. It can be accessed through the following means: This data can be accessed by contacting the data owners. Access to the data requires an approved Institutional Review Board application from an appropriate institution. Format: This dataset include blood biomarker measurements (DNA methylation; Ilumina EPIC Methylation array) along with demographic and anthropomorphic information on participants. In addition there is data on which controlled exposure was received (clean air or diesel or ozone) and at which time points. This dataset is associated with the following publications: Cardenas, A., R. Fadadu, L. Van Der Laan, C. Ward-Caviness, L. Granger, D. Diaz-Sanchez, M. Bind, and R. Devlin. Controlled Human Exposures to Diesel Exhaust: A Human Epigenome-Wide Experiment of Target Bronchial Epithelial Cells. Environmental Epigenetics. Oxford University Press, Cary, NC, USA, 7(1): dvab003, (2021). Bind, M., D. Rubin, A. Cardenas, R. Dhingra, C. Ward-Caviness, Z. Liu, J. Mirowsky, J. Schwartz, B. Coull, D. Diazsanchez, and R. Devlin. HETEROGENEOUS OZONE EFFECTS ON DNA METHYLOME OF BRONCHIAL CELLS: OBSERVED IN A CROSSOVER STUDY. Scientific Reports. Nature Publishing Group, London, UK, 10(1): 15739, (2020).

Dataset contains a list of metabolites, their fold change after ozone exposure and a p value for that change. This dataset is not publicly accessible because: EPA cannot release personally identifiable information regarding living individuals, according to the Privacy Act and the Freedom of Information Act (FOIA). This dataset contains information about human research subjects. Because there is potential to identify individual participants and disclose personal information, either alone or in combination with other datasets, individual level data are not appropriate to post for public access. Restricted access may be granted to authorized persons by contacting the party listed. It can be accessed through the following means: This dataset can be accessed by contacting Dr. Robert Devlin (devlin.rober@epa.gov). Format: The dataset was sent to us by the company (Metabolon) that did the metabolite analysis, including the statistical analysis). It is an excel spreadsheet that contains a row for each of the metabolites that were identified, fold changes in each metabolite after air and ozone exposure (and the p value of the ozone-induced change), and the pathway and superpathway to which each metabolite belongs. This dataset is associated with the following publication: Cheng, W., K. Duncan, A. Ghio, C. Ward-Caviness, E. Karoly, D. Diaz-Sanchez, R. Conolly, and R. Devlin. Changes in metabolites present in lung-lining fluid following exposure to humans to ozone. TOXICOLOGICAL SCIENCES. Society of Toxicology, RESTON, VA, 163(2): 430-439, (2018).

Dataset contains a list of metabolites, their fold change after ozone exposure and a p value for that change. This dataset is not publicly accessible because: EPA cannot release personally identifiable information regarding living individuals, according to the Privacy Act and the Freedom of Information Act (FOIA). This dataset contains information about human research subjects. Because there is potential to identify individual participants and disclose personal information, either alone or in combination with other datasets, individual level data are not appropriate to post for public access. Restricted access may be granted to authorized persons by contacting the party listed. It can be accessed through the following means: This dataset can be accessed by contacting Dr. Robert Devlin (devlin.rober@epa.gov). Format: The dataset was sent to us by the company (Metabolon) that did the metabolite analysis, including the statistical analysis). It is an excel spreadsheet that contains a row for each of the metabolites that were identified, fold changes in each metabolite after air and ozone exposure (and the p value of the ozone-induced change), and the pathway and superpathway to which each metabolite belongs. This dataset is associated with the following publication: Cheng, W., K. Duncan, A. Ghio, C. Ward-Caviness, E. Karoly, D. Diaz-Sanchez, R. Conolly, and R. Devlin. Changes in metabolites present in lung-lining fluid following exposure to humans to ozone. TOXICOLOGICAL SCIENCES. Society of Toxicology, RESTON, VA, 163(2): 430-439, (2018).

Annual mortality rates for US counties, air pollution concentrations. This dataset is not publicly accessible because: EPA cannot release personally identifiable information regarding living individuals, according to the Privacy Act and the Freedom of Information Act (FOIA). This dataset contains information about human research subjects. Because there is potential to identify individual participants and disclose personal information, either alone or in combination with other datasets, individual level data are not appropriate to post for public access. Restricted access may be granted to authorized persons by contacting the party listed. It can be accessed through the following means: Please contact corresponding author. Format: Data is saved in Ascii and netcdf format. This dataset is associated with the following publication: Peterson, G., C. Hogrefe, L. Neas, A. Corrigan, R. Mathur, and A. Rappold. Impacts of Reductions in Emissions from Major Source Sectors on Fine Particulate Matter-Related Cardiovascular Mortality. ENVIRONMENTAL HEALTH PERSPECTIVES. National Institute of Environmental Health Sciences (NIEHS), Research Triangle Park, NC, USA, 128(1): 17005, (2020).

Annual mortality rates for US counties, air pollution concentrations. This dataset is not publicly accessible because: EPA cannot release personally identifiable information regarding living individuals, according to the Privacy Act and the Freedom of Information Act (FOIA). This dataset contains information about human research subjects. Because there is potential to identify individual participants and disclose personal information, either alone or in combination with other datasets, individual level data are not appropriate to post for public access. Restricted access may be granted to authorized persons by contacting the party listed. It can be accessed through the following means: Please contact corresponding author. Format: Data is saved in Ascii and netcdf format. This dataset is associated with the following publication: Peterson, G., C. Hogrefe, L. Neas, A. Corrigan, R. Mathur, and A. Rappold. Impacts of Reductions in Emissions from Major Source Sectors on Fine Particulate Matter-Related Cardiovascular Mortality. ENVIRONMENTAL HEALTH PERSPECTIVES. National Institute of Environmental Health Sciences (NIEHS), Research Triangle Park, NC, USA, 128(1): 17005, (2020).

The dataset contains information on medical history, residential information and demographic information on CATHGEN participants as well as modeled PM2.5 values at participants' residence. This dataset is not publicly accessible because: The data are human subjects data containing potential identifiable information (PII) and therefore access is restricted to the study investigators. Because base data are owned by other entities, these data need to be requested directly from Duke University. It can be accessed through the following means: These data can accessed upon request to the CATHGEN steering committee at Duke University. Format: Data are stored as SAS files on secure EPA drives. This dataset is associated with the following publication: Weaver, A., L. McGuinn, L. Neas, J. Mirowsky, R. Devlin, R. Dhingra, C. Ward-Caviness, W. Cascio, W. Kraus, E. Hauser, Q. Di, J. Schwartz, and D. Diaz-Sanchez. Neighborhood sociodemographic effects on the associations between long-term PM2.5 exposure and cardiovascular outcomes and diabetes. Journal of Exposure Science and Environmental Epidemiology. Nature Publishing Group, London, UK, 3(1): e038, (2019).

The dataset contains information on medical history, residential information and demographic information on CATHGEN participants as well as modeled PM2.5 values at participants' residence. This dataset is not publicly accessible because: The data are human subjects data containing potential identifiable information (PII) and therefore access is restricted to the study investigators. Because base data are owned by other entities, these data need to be requested directly from Duke University. It can be accessed through the following means: These data can accessed upon request to the CATHGEN steering committee at Duke University. Format: Data are stored as SAS files on secure EPA drives. This dataset is associated with the following publication: Weaver, A., L. McGuinn, L. Neas, J. Mirowsky, R. Devlin, R. Dhingra, C. Ward-Caviness, W. Cascio, W. Kraus, E. Hauser, Q. Di, J. Schwartz, and D. Diaz-Sanchez. Neighborhood sociodemographic effects on the associations between long-term PM2.5 exposure and cardiovascular outcomes and diabetes. Journal of Exposure Science and Environmental Epidemiology. Nature Publishing Group, London, UK, 3(1): e038, (2019).

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