Results of partial least squares (PLS) analysis of metabolite changes and contaminant concentrations to determine contaminants most likely to responsible for biological effects and to screen against those contaminants not responsible. This dataset is associated with the following publication: Ekman, D., K. Keteles, J. Beihoffer, J. Cavallin, K. Dahlin, J. Davis, A. Jastrow, J. Lazorchak, M. Mills, M. Murphy, D. Nguyen, A. Vajda, D. Villeneuve, D. Winkelman, and T. Collette. Evaluation of targeted and untargeted effects-based monitoring tools to assess impacts of contaminants of emerging concern on fish in the South Platte River, CO. ENVIRONMENTAL POLLUTION. Elsevier Science Ltd, New York, NY, USA, 239: 706-713, (2018).

The U.S. Geological Survey (USGS), in cooperation with the U.S. Fish and Wildlife Service (USFWS) and St. Cloud State University (SCSU), identified the occurrence of chemicals of emerging concern (CECs) in water and bottom sediment collected in 2014 at 65 sites throughout the Great Lakes Basin. The 2014 effort is part of a long-term study that began in 2010. Included in this directory are collection methods, references to or descriptions of analytical methods used, data for samples collected in 2014, and associated quality-assurance data. Samples were collected during the periods of April to May and August to September by USGS, USFWS, and (or) SCSU personnel. Study sites include tributaries to the Great Lakes located near Green Bay, Wisconsin; Chicago, Illinois; Detroit, Michigan; Grand Rapids, Michigan; Cleveland, Ohio; and Wanakena, New York. During this study, 204 environmental samples and 6 field replicate sample pairs of surface water, 6 field blank water samples, and 4 laboratory-matrix spike water samples were collected or prepared. Additionally, 21 environmental samples, 3 field replicate sample pairs, and 2 laboratory-matrix spike samples of bottom sediments were collected or prepared. At 22 select water-quality sites, polar organic chemical integrative samplers (POCIS) were deployed in water and analyzed for a similar suite of CECs as were measured in water and bottom-sediment samples. A total of 22 environmental samples, 4 field-blank samples (exposed to ambient air), and 4 field replicate sample pairs were collected or prepared. Water and bottom-sediment samples were prepared and analyzed at the USGS National Water Quality Laboratory (NWQL) in Denver, Colorado. All POCIS samples were extracted at the Environmental Sampling Technologies Laboratory in St. Joseph, Missouri. Extracts were sent to NWQL where final preparation steps and analyses were completed.

The U.S. Geological Survey (USGS), in cooperation with the U.S. Fish and Wildlife Service (USFWS) and St. Cloud State University (SCSU), identified the occurrence of chemicals of emerging concern (CECs) in water and bottom sediment collected in 2014 at 65 sites throughout the Great Lakes Basin. The 2014 effort is part of a long-term study that began in 2010. Included in this directory are collection methods, references to or descriptions of analytical methods used, data for samples collected in 2014, and associated quality-assurance data. Samples were collected during the periods of April to May and August to September by USGS, USFWS, and (or) SCSU personnel. Study sites include tributaries to the Great Lakes located near Green Bay, Wisconsin; Chicago, Illinois; Detroit, Michigan; Grand Rapids, Michigan; Cleveland, Ohio; and Wanakena, New York. During this study, 204 environmental samples and 6 field replicate sample pairs of surface water, 6 field blank-water samples, and 4 laboratory-matrix spike water samples were collected or prepared. Additionally, 21 environmental samples, 3 field replicate sample pairs, and 2 laboratory-matrix spike samples of bottom sediments were collected or prepared. At 22 select water-quality sites, polar organic chemical integrative samplers (POCIS) were deployed in water and analyzed for a similar suite of CECs as were measured in water and bottom-sediment samples. A total of 22 environmental samples, 4 field-blank samples (exposed to ambient air), and 4 field replicate sample pairs were collected or prepared. Water and bottom-sediment samples were prepared and analyzed at the USGS National Water Quality Laboratory (NWQL) in Denver, Colorado. All POCIS samples were extracted at the Environmental Sampling Technologies Laboratory in St. Joseph, Missouri. Extracts were sent to NWQL where final preparation steps and analyses were completed. The Field and Laboratory Quality Assurance provides eight tables that support the analytical results for wastewater compounds, steroid hormones, sterols, and bisphenol A, and pharmaceuticals in water, sediment, and POCIS samples collected during 2014.

The U.S. Geological Survey (USGS), in cooperation with the U.S. Fish and Wildlife Service (USFWS) and the U.S. Environmental Protection Agency (EPA), identified the occurrence of contaminants of emerging concern (CECs) in water and bottom sediments collected in 2013 at 57 sites throughout the Great Lakes Basin. The 2013 effort is part of a long-term study that began in 2010. Included in this directory are collection methods, references to or descriptions of analytical methods used, data for samples collected in 2013, and associated quality-assurance data. Samples were collected from April through October 2013 by USGS, USFWS, and/or EPA personnel. Study sites include tributaries to the Great Lakes located near Duluth, Minnesota; Kewaunee, Wisconsin; Appleton, Wisconsin; Detroit, Michigan; Grand Rapids, Michigan; St Clair, Michigan; Cleveland, Ohio; Wanakena, New York; and Potsdam, New York (see "2013 Site List"). During this study, 93 environmental samples and 6 field replicate sample pairs of surface water, 3 field blank water samples, and 3 laboratory-matrix spike water samples were collected or prepared. Additionally, 49 environmental samples, 4 field replicate sample pairs, and two laboratory-matrix spike samples of bottom sediment were collected or prepared. Water and bottom-sediment samples were analyzed at the USGS National Water Quality Laboratory in Denver, Colorado, for a broad suite of CECs. The Environmental Data provides 4 tables that describes the analytical results for wastewater compounds, steroid hormones, sterols, and bisphenol A, and pharmaceuticals in water and wastewater compounds, steroid hormones, sterols, and bisphenol A, pharmaceuticals, and antidepressants in bottom-sediment samples collected during 2013.

The U.S. Geological Survey (USGS), in cooperation with the U.S. Fish and Wildlife Service (USFWS) and the U.S. Environmental Protection Agency (EPA), identified the occurrence of contaminants of emerging concern (CECs) in water and bottom sediments collected in 2013 at 57 sites throughout the Great Lakes Basin. The 2013 effort is part of a long-term study that began in 2010. Included in this directory are collection methods, references to or descriptions of analytical methods used, data for samples collected in 2013, and associated quality-assurance data. Samples were collected from April through October 2013 by USGS, USFWS, and/or EPA personnel. Study sites include tributaries to the Great Lakes located near Duluth, Minnesota; Kewaunee, Wisconsin; Appleton, Wisconsin; Detroit, Michigan; Grand Rapids, Michigan; St Clair, Michigan; Cleveland, Ohio; Wanakena, New York; and Potsdam, New York (see "2013 Site List"). During this study, 93 environmental samples and 6 field replicate sample pairs of surface water, 3 field blank water samples, and 3 laboratory-matrix spike water samples were collected or prepared. Additionally, 49 environmental samples, 4 field replicate sample pairs, and two laboratory-matrix spike samples of bottom sediment were collected or prepared. Water and bottom-sediment samples were analyzed at the USGS National Water Quality Laboratory in Denver, Colorado, for a broad suite of CECs.

Water-borne contaminants were monitored in 69 tributaries of the Laurentian Great Lakes in 2010 and 2014 using semipermeable membrane devices (SPMDs), and polar organic chemical integrative samplers (POCIS). Analyses included 185 chemicals (143 detected) including PAHs, legacy and current-use pesticides, fire retardants, pharmaceuticals, fragrances, and others. Hazard quotients were calculated by dividing detected concentrations by biological effect concentrations reported in the ECOTOX Knowledgebase (Toxicity quotients, TQs) or ToxCast database (Exposure Activity Ratios, EARs). This dataset is associated with the following publication: Alvarez, D., S. Corsi, L. De Cicco, D. Villeneuve, and A. Baldwin. Identifying chemicals and mixtures of potential biological concern detected in passive samplers from Great Lakes tributaries using high-throughput data and biological pathways. ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY. Society of Environmental Toxicology and Chemistry, Pensacola, FL, USA,

Data were created in order to examine mercury concentrations, cycling, and biotic transfer in the Great Lakes and is in response to mercury concentrations in fish that are above consumption advisory levels. This dataset is associated with the following publication: Ogorek, J., R. Lepak, J. Hoffman, J. DeWild, T. Rosera, M. Tate, J. Hurley, and D. Krabbenhoft. Enhanced sensitivity of methylmercury bioaccumulation into seston of the Laurentian Great Lakes. ENVIRONMENTAL SCIENCE & TECHNOLOGY. American Chemical Society, Washington, DC, USA, 55(18): 12714-12723, (2021).

In vitro biological activity data from a extracts of a nationwide survey of US streams. This dataset is associated with the following publication: Blackwell, B., G. Ankley, P. Bradley, K. Houck, S.S. Makarov, A. Medvedev, J. Swintek, and D. Villeneuve. Potential toxicity of complex mixtures in surface waters from a nationwide survey of United States streams: Identifying in vitro bioactivities and causative chemicals. ENVIRONMENTAL SCIENCE & TECHNOLOGY. American Chemical Society, Washington, DC, USA, 53(2): 973-983, (2019).

In vitro biological activity data from a extracts of a nationwide survey of US streams. This dataset is associated with the following publication: Blackwell, B., G. Ankley, P. Bradley, K. Houck, S.S. Makarov, A. Medvedev, J. Swintek, and D. Villeneuve. Potential toxicity of complex mixtures in surface waters from a nationwide survey of United States streams: Identifying in vitro bioactivities and causative chemicals. ENVIRONMENTAL SCIENCE & TECHNOLOGY. American Chemical Society, Washington, DC, USA, 53(2): 973-983, (2019).

Dataset for "Pronschinske, M.A., Corsi, S.R., DeCicco, L.A., Furlong, E.T., Ankley, G.T., Blackwell, B.R., Villeneuve, D.L., Lenaker, P.L. and Nott, M.A. (2022), Prioritizing Pharmaceutical Contaminants in Great Lakes Tributaries Using Risk-Based Screening Techniques. Environ Toxicol Chem, 41: 2221-2239. https://doi.org/10.1002/etc.5403". This dataset is associated with the following publication: Pronschinske, M., S. Corsi, L. DeCicco, E. Furlong, G. Ankley, B. Blackwell, D. Villeneuve, P. Lenaker, and M. Nott. Prioritizing Pharmaceutical Contaminants in Great Lakes Tributaries Using Risk-Based Screening Techniques.. ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY. Society of Environmental Toxicology and Chemistry, Pensacola, FL, USA, 41(9): 2221-2239, (2022).