Final Prenatal Dataset
공공데이터포털
Full data tables presented in the Supplemental Information in Excel format. This dataset is associated with the following publication: Nilsen, F., J. Frank, and N. Tulve. A systematic review and meta-analysis investigating the relationship between exposures to chemical and non-chemical stressors during prenatal development and childhood externalizing behaviors. International Journal of Environmental Research and Public Health. Molecular Diversity Preservation International, Basel, SWITZERLAND, 17(7): 2361, (2020).
Scientific journal article
공공데이터포털
Files associated with the manuscript: Proteome profiling of rat brain cortical changes during early postnatal brain development. This dataset is associated with the following publication: Winnik, W., W. Padgett, E. Pitzer, and D. Herr. Proteome profiling of rat brain cortical changes during early postnatal brain development. Journal of Proteome Research. American Chemical Society, Washington, DC, USA, 22(7): 2460-2476, (2023).
Full data appendix
공공데이터포털
General cognitive ability, often referred to as ‘general intelligence’, comprises a variety of correlated abilities. Childhood general cognitive ability is a well-studied area of research and can be used to predict social outcomes and perceived success. Early life stage (e.g., prenatal, postnatal, toddler) exposures to stressors (i.e., chemical and non-chemical stressors from the total (built, natural, social) environment) can impact the development of childhood cognitive ability. Building from our systematic scoping review (Ruiz et al., 2016), we conducted a meta-analysis to evaluate more than 100 stressors related to cognitive development. Our meta-analysis identified 23 stressors with a significant increase in their likelihood to influence childhood cognitive ability by 10% or more, and 80 stressors were observed to have a statistically significant effect on cognitive ability. Stressors most impactful to cognition during the prenatal period were related to maternal health and the mother’s ability to access information relevant to a healthy pregnancy (e.g., diet, lifestyle). Stressors most impactful to cognition during the early childhood period were dietary nutrients (infancy), quality of social interaction (toddler), and exposure to toxic substances (throughout early childhood). In conducting this analysis, we examined the relative impact of real-world exposures on cognitive development to attempt to understand the inter-relationships between exposures to both chemical and non-chemical stressors and early developmental life stages. Our findings suggest that the stressors observed to be the most influential to childhood cognitive ability are not permanent and can be broadly categorized as activities/behaviors which can be modified to improve childhood cognition. This meta-analysis supports the idea that there are complex relationships between a child’s total environment and early cognitive development. This dataset is associated with the following publication: Nilsen, F., J. Ruiz, and N. Tulve. A Meta-Analysis of Stressors from the Total Environment Associated with Children’s General Cognitive Ability. International Journal of Environmental Research and Public Health. Molecular Diversity Preservation International, Basel, SWITZERLAND, 17(15): 5451, (2020).
Prenatal Alcohol and Other Drug Exposures in Child Welfare Study: Final Report
공공데이터포털
This report presents the results of a federally funded study that examined federal and State policies guiding child welfare prenatal substance exposure (PSE) identification and care, child welfare staff awareness and knowledge of PSE and practices to identify affected children and families, how PSE information is shared and documented, and how child welfare agencies interact with caregivers and allied service providers in supporting children and families. The study included interviews with child welfare directors and reviews of State policy documents pertaining to PSE in five States; interviews with child welfare staff and directors (n=171) at 22 agency sites, as well as a survey of allied PSE-relevant service providers (n=271), and a review of local agency-level policy documents; and in-depth interviews with 13 local agency data staff at two States, as well as a survey of 21 allied PSE-relevant service providers, focus groups or interviews with 48 caregivers, and a review of 212 local agency case files. Results from the study are reported and indicate: States reported policy revisions and enhanced collaborative partnerships in response to CAPTA/CARA legislation; defining prenatal exposure as child maltreatment may be a barrier to providing supportive services to families; most staff reported participating in training related to PSE and stated a high level of awareness about the effects of PSE, yet many displayed inaccurate knowledge about the effects of prenatal alcohol syndrome; staff reported inconsistent assessment for PSE; when PSE is a concern, most CW staff reported that they would refer to developmental and early intervention services along with medical providers; PSE information was not consistently located in a single report or location; and among the caregivers who had cared for a child with PSE, few reported that they were fully prepared to do so. Additional findings are reported and recommendations are made. Metadata-only record linking to the original dataset. Open original dataset below.