Raw data for glucocorticoid receptor ligand exposure experiments. This dataset is associated with the following publication: MedlockKakaley, E., M. Cardon, E. Gray, P. Hartig, and V. Wilson. Generalized concentration addition model predicts glucocorticoid activity bioassay responses to environmentally detected receptor-ligand mixtures. TOXICOLOGICAL SCIENCES. Society of Toxicology, RESTON, VA, 252-263, (2019).

Raw data for each glucocorticoid ligand mixtures experiment. This dataset is associated with the following publication: MedlockKakaley, E., M. Cardon, E. Gray, P. Hartig, and V. Wilson. Generalized concentration addition model predicts glucocorticoid activity bioassay responses to environmentally detected receptor-ligand mixtures. TOXICOLOGICAL SCIENCES. Society of Toxicology, RESTON, VA, 252-263, (2019).

This data release includes datasets provided by the Woolnough Laboratory at Central Michigan University. These data were collected as a part of a laboratory exposure experiment, conducted in 2018, examining the effects of agricultural and urban contaminant mixtures on two life stages (larval and juvenile) of the freshwater mussel, plain pocketbook (Lampsilis cardium), using largemouth bass (Micropterus salmoides) as the host fish. Contaminant mixtures were representative of contaminants frequently detected in agricultural and urban settings. Agricultural contaminant mixtures consisted of bromacil, estrone, metolachlor, tri(butoxyethyl) phosphate, 4-nonylphenol, atrazine, N,N-diethyl-meta-toluamide (DEET), and bisphenol A. Urban contaminant mixtures consisted of metformin, sulfamethoxazole, desvenlafazine, and 5-methyl-1H-benzotriazole. Lampsilis cardium and M. salmoides were exposed to either an agricultural or urban contaminant mixture, control water treatment, or control ethanol treatment for 40 or 100 days. Throughout the exposure periods, water samples were collected from the contaminant mixture holding tanks for verification of concentration dosing. Gravid adult female L. cardium and M. salmoides were exposed to a specified treatment for 13 or 60 days. During this exposure period, prematurely released glochidia (L. cardium larvae) were enumerated. After the initial exposure period, glochidia were stripped from gravid female L. cardium, enumerated, and inoculated into M. salmoides tanks of the corresponding treatment for infestation and encystment. After infestation, parasitic glochidia and M. salmoides host fish were exposed for 27 or 40 more days (40- and 100-day total exposure durations, respectively). During this exposure period, glochidia that dropped off the host fish were enumerated and observations of their metamorphose state (partially or fully metamorphosed) were documented. The data contained in this data release were analyzed and discussed in the primary publication titled “Reduced freshwater mussel juvenile production as a result of agricultural and urban contaminant mixture exposures” (https://doi.org/xxxxxx).

GC/MS metabolomic data from livers of amphibians exposed to pesticides. This dataset is associated with the following publication: Glinski, D., T. Purucker, R. Van Meter, M. Black, and M. Henderson. Endogenous and exogenous biomarker analysis in terrestrial phase amphibians (Lithobates sphenocephala) following dermal exposure to pesticide mixtures. ENVIRONMENTAL CHEMISTRY. CSIRO Publishing, Collingwood Victoria, AUSTRALIA, 16(1): 55-67, (2019).

GC/MS data from the metabolomic profiling of green frog livers after exposure to pesticides and their mixtures. This dataset is associated with the following publication: Van Meter, R., D. Glinski, T. Purucker, and M. Henderson. Influence of exposure to pesticide mixtures on the metabolomic profile in post-metamorphic green frogs (Lithobates clamitans). SCIENCE OF THE TOTAL ENVIRONMENT. Elsevier BV, AMSTERDAM, NETHERLANDS, 624: 1348-1359, (2018).

• 생활화학제품에 포함된 주성분의 GHS 코드, CAS 번호, 독성 수치 등 과학적 메타정보를 표준화하여 수집• 켐토피아 보유 DB 및 국내 공공기관 화학제품안전포털 초록누리, 산업안전보건공단, 해외 ECHA, PubChem, eChemportal, NITE-CRIP 웹사이트를 활용한 웹크롤링 방식으로 원시데이터 확보 • 정제 데이터는 InChI, SMILES, IUPAC 명명법, 분자식(MF), 몰질량(MW) 등 메타정보 포함 • Instruction 포맷 기반으로 가공하여, 설명분 원천데이터 1건당 1:2 Q/A 형태로 데이터 생성

Publicly available dataset containing chemical exposure data. This dataset is associated with the following publication: Lin, Y., V. Morozov, A. Kadry, J. Caffrey , and W. Chou. Reconstructing population exposures to acrylamide from human monitoring data using a pharmacokinetic framework. CHEMOSPHERE. Elsevier Science Ltd, New York, NY, USA, 331: 138798, (2023).

Data from study assessing the utility of knowledgebase-leveraging of comprehensive environmental-contaminant-exposure datasets by comparing biological effects predicted on the basis of target chemical analyses with measured biological effects in corresponding split water samples.

The dataset contains the metadata associated with the figures in the manuscript. This dataset is associated with the following publication: Corteselli, E., E. Gibbs-Flournoy, S. Simmons, P. Bromberg, A. Gold, and J.M. Samet. Long Chain Lipid Hydroperoxides Increase the Glutathione Redox Potential Through Glutathione Peroxidase 4. Biochimica et Biophysica Acta. Elsevier Science Ltd, New York, NY, USA, 1863(5): 950-959, (2019).