Biocrates metabolomics data for cerebrospinal fluid, serum, plasma, and urine from rats dosed with trimethyl tin at 2, 6, 10, or 14 days after treatmetn. This dataset is associated with the following publication: Imam, S., Z. He, E. Cuevas, H. Rosas-Hernandez, S. Lantz, S. Sarkar, J. Raymick, B. Robinson, J. Hanig, D. Herr, D. MacMillan, A. Smith, S. Liachenko, S. Ferguson, J. O'Callaghan, D. Miller, C. Somps, I. Pardo, W. Slikker, J. Pierson, R. Roberts, B. Gong, W. Tong, M. Aschner, M.J. Kallman, D. Calligaro, and M. Paule. Changes in the metabolome and microRNA levels in biological fluids might represent biomarkers of neurotoxicity: A trimethyltin study. Experimental Biology and Medicine. SAGE Publications, THOUSAND OAKS, CA, USA, 243(3): 228-236, (2018).

data supporting manuscript figures. This dataset is associated with the following publication: Moser , V.C., P. Phillips , J. Hedge , and K. Mcdaniel. Neurotoxicological and thyroid evaluations of rats developmentally exposed to tris(1,3-dichloro-2-propyl)phosphate (TDICPP) and tris(2-chloro-2-ethyl)phosphate(TCEP). NEUROTOXICOLOGY AND TERATOLOGY. Elsevier Science Ltd, New York, NY, USA, 52: 236-247, (2015).

data supporting manuscript figures. This dataset is associated with the following publication: Moser , V.C., P. Phillips , J. Hedge , and K. Mcdaniel. Neurotoxicological and thyroid evaluations of rats developmentally exposed to tris(1,3-dichloro-2-propyl)phosphate (TDICPP) and tris(2-chloro-2-ethyl)phosphate(TCEP). NEUROTOXICOLOGY AND TERATOLOGY. Elsevier Science Ltd, New York, NY, USA, 52: 236-247, (2015).

Liquid-chromatography-mass spectrometry (LC-MS) raw data sets from various instruments delivered in their native instrument format. 31 files in all. 7.5 GB data.

Liquid-chromatography-mass spectrometry (LC-MS) raw data sets from various instruments delivered in their native instrument format. 31 files in all. 7.5 GB data.

Microarray experiments used in the study. This dataset is associated with the following publication: Corton, J., K. Korunes, J. Abedini, H. El-Masri, J. Brown, K. Friedman, Y. Liu, C. Martini, S. He, and J. Rooney. Thresholds Derived from Common Measures in Rat Studies are Predictive of Liver Tumorigenic Chemicals. TOXICOLOGIC PATHOLOGY. Society of Toxicology, RESTON, VA, 48(7): 857-874, (2020).

Microarray experiments used in the study. This dataset is associated with the following publication: Corton, J., K. Korunes, J. Abedini, H. El-Masri, J. Brown, K. Friedman, Y. Liu, C. Martini, S. He, and J. Rooney. Thresholds Derived from Common Measures in Rat Studies are Predictive of Liver Tumorigenic Chemicals. TOXICOLOGIC PATHOLOGY. Society of Toxicology, RESTON, VA, 48(7): 857-874, (2020).

This dataset provides measured in vitro intrinsic clearance rates for 54 chemicals tested using isolated hepatocytes from humans, rats, and rainbow trout. The test chemicals were selected to provide broad coverage across the industrial and pesticidal chemical space while also prioritizing chemicals of interest to EPA’s Endocrine Disruptor Screening Program (EDSP). A data evaluation framework was developed to identify results suitable for rate reporting. Acceptable results were then used to evaluate the chemical domain of applicability of the applied methods, the influence of starting substrate concentration on measured rates of intrinsic clearance, and differences in metabolic activity among species. These findings provide data for chemicals of specific interest to the EDSP. More importantly, the results provide critical guidance on future use of in vitro biotransformation assays to support high-throughput chemical risks assessments. This dataset is associated with the following publication: Black, S., J. Nichols, K. Fay, S. Matten, and S. Lynn. Evaluation and comparison of in vitro intrinsic hepatic clearance rates measured using cryopreserved hepatocytes from humans, rats, and rainbow trout. TOXICOLOGY. Elsevier Science Ltd, New York, NY, USA, 457: 152819, (2021).

This dataset provides measured in vitro intrinsic clearance rates for 54 chemicals tested using isolated hepatocytes from humans, rats, and rainbow trout. The test chemicals were selected to provide broad coverage across the industrial and pesticidal chemical space while also prioritizing chemicals of interest to EPA’s Endocrine Disruptor Screening Program (EDSP). A data evaluation framework was developed to identify results suitable for rate reporting. Acceptable results were then used to evaluate the chemical domain of applicability of the applied methods, the influence of starting substrate concentration on measured rates of intrinsic clearance, and differences in metabolic activity among species. These findings provide data for chemicals of specific interest to the EDSP. More importantly, the results provide critical guidance on future use of in vitro biotransformation assays to support high-throughput chemical risks assessments. This dataset is associated with the following publication: Black, S., J. Nichols, K. Fay, S. Matten, and S. Lynn. Evaluation and comparison of in vitro intrinsic hepatic clearance rates measured using cryopreserved hepatocytes from humans, rats, and rainbow trout. TOXICOLOGY. Elsevier Science Ltd, New York, NY, USA, 457: 152819, (2021).

General toxicology, clinical chemistry, complete blood counts, histopathology, gene expression. This dataset is associated with the following publication: Chernoff, N., D. Hill, I. Chorus, D. Diggs, H. Huang, D. King, J. Lang, T. Le, J. Schmid, G. Travlos, E. Whitley, R. Wilson, and C. Wood. Cylindrospermopsin toxicity in mice following a 90-d oral exposure. ENVIRONMENTAL TOXICOLOGY. John Wiley & Sons, Ltd., Indianapolis, IN, USA, 549-566, (2018).