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In Vivo Testing HSAB
Contains nerve excitability data (tail and foot CMAP, tail mixed nerve), compound nerve action potentials, nerve conduction velocity, cortical and cerebellar somatosensory evoked potentials after treatment with citronellal, 3,4-dichloro-1-butene, or benzyl bromoacetate. Contains extracted data and analysis. This dataset is associated with the following publication: Herr, D., G. Jung, K. McDaniel, R. LoPachin, B. Geohagen, A. Smith, and M. Huffstickler. IN VIVO NEUROPHYSIOLOGICAL ASSESSMENT OF IN SILICO PREDICTIONS OF NEUROTOXICITY: CITRONELLAL, 3,4-DICHLORO-1-BUTENE, AND BENZYL BROMOACETATE. NEUROTOXICOLOGY. Elsevier B.V., Amsterdam, NETHERLANDS, 90(1): 48-61, (2022).
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Melnikov etal Hard and Soft Acid and Base Characterization of 100 Chemicals
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Characterization of 100 chemicals for electrophillic potential using Hard and Soft Acid and Bases theory. The chemicals were ranked for electrophillic potential and a group of chemicals within a range of electrophillic values were identified as having properties similar to other neurotoxicants. This dataset is associated with the following publication: Melnikov, F., B. Geohagen, T. Gavin, R. LoPachin, P. Anastas, P. Coish, and D. Herr. Application of the Hard and Soft, Acids and Bases (HSAB) Theory as a Method to Predict Cumulative Neurotoxicity. NEUROTOXICOLOGY. Elsevier B.V., Amsterdam, NETHERLANDS, 79: 95-103, (2020).
KodavantiP-Acute HSAB AOP Neurotox Science Hub Data 090319
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Neurotox data on in silico predicted chemicals to cause protein adducts in peripheral neurons. Includes cytotoxicity (LDH release), changes in neuron network architecture using high content imaging and neurophysiology via microelectrode arrays. This dataset is associated with the following publication: Johnstone, A., C. Mack, M. Valdez, T. Shafer, D. Herr, P. Kodavanti, and R. Lo Pachin. Acute In Vitro Effects on Embryonic Rat Dorsal Root Ganglion (DRG) Cultures by In Silico Predicted Neurotoxic Chemicals: Evaluations on Cytotoxicity, Neurite Length, and Neurophysiology.. TOXICOLOGY IN VITRO. Elsevier Science Ltd, New York, NY, USA, 69(104989): 1, (2020).
Screening silver nanoparticles for potential neurotoxicity using cortical neurons grown on microelectrode arrays
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the zip files contain outputs from the R-analysis for the nanosilver experiments. This dataset is associated with the following publication: Strickland, J., W. LeFew, J. Crooks, D. Hall, J. Ortenzio , K. Dreher , and T. Shafer. In vitro screening of silver nanoparticles and ionic silver using neural networks yields differential effects on spontaneous activity and pharmacological responses.. TOXICOLOGY. Elsevier Science Ltd, New York, NY, USA, 355(11): 1-8, (2016).
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