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Lung surfactant in subacute pulmonary disease
Pulmonary surfactant is a surface active material composed of both lipids and proteins that is produced by alveolar type II pneumocytes. Abnormalities of surfactant in the immature lung or in the acutely inflamed mature lung are well described. However, in a variety of subacute diseases of the mature lung, abnormalities of lung surfactant may also be of importance. These diseases include chronic obstructive pulmonary disease, asthma, cystic fibrosis, interstitial lung disease, pneumonia, and alveolar proteinosis. Understanding of the mechanisms that disturb the lung surfactant system may lead to novel rational therapies for these diseases.
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Narodowy Fundusz Zdrowia - Przewlekła obturacyjna choroba płuc, styczeń 2020 – listopad 2024
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,Zestawienie zawiera informacje o liczbie pacjentów ze sprawozdanymi świadczeniami z rozpoznaniem głównym lub współistniejącym przewlekłej obturacyjnej choroby płuc (ICD-10: J44) w leczeniu szpitalnym w okresie od stycznia 2020 roku do listopada 2024 roku.,
Particulate Matter Identification in Lung Tissue from Deployers, Positive, and Negative controls Using Scanning Electron Microscopy and Energy Dispersive Spectroscopy (2013-2016)
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We developed and tested a new method for in situ characterization and distribution of inorganic particles in biopsied lung tissue from three diverse human subject groups using field emission scanning electron microscopy with an energy dispersive analyzer. Backscattered electron and secondary electron images of particulate matter in lung tissue were acquired. Inorganic particulate matter in the field of view of the image was analyzed using energy dispersive spectroscopy and subsequently identified and cataloged.
Identifying Trans-Epithelial Effects of Inhaled Chemical Exposures on Stromal-Epithelial Oxidative Stress Dynamics in the Human Airway
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Data include: trans-epithelial electrical resistance, FITC-dextran permeability, cell viability and gene expression (RNA and protein). This dataset is associated with the following publication: Faber, S., N. McNabb, P. Ariel, E. Aungst, and S. McCullough. Exposure Effects Beyond the Epithelial Barrier: Trans-Epithelial Induction of Oxidative Stress by Diesel Exhaust Particulates in Lung Fibroblasts in an Organotypic Human Airway Model. TOXICOLOGICAL SCIENCES. Society of Toxicology, RESTON, VA, 177(1): 140-155, (2020).
Ozone-induced systemic and pulmonary effects are diminished in adrenalectomized rats
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This data set is an excel file pertaining to the study that examined ozone-induced systemic and pulmonary effects in rats that underwent SHAM surgery (control), adrenal demedullation or total bilateral adrenalectomy. Different pages of the spreadsheet shows individual animal data for markers of lung injury and inflammation, body weights, whole body plethysmography measurements, levels of circulating hormones and lipids, and circulating white blood cell count as well as platelet count. This dataset is associated with the following publication: Miller, D., S. Snow, M. Schladweiler , J. Richards , A. Ghio , A. Ledbetter , and U. Kodavanti. Acute Ozone-Induced Pulmonary and Systemic Metabolic Effects are Diminished in Adrenalectomized Rats#. TOXICOLOGICAL SCIENCES. Society of Toxicology, 150(2): 312-22, (2016).
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