Mobile Map Packages (MMPK’s) can be used in the ESRI Field Maps app (no login required), either by direct download in the Field Maps app or by sideloading from your PC. They can also be used in desktop applications that support MMPK’s such as ArcGIS Pro, and ArcGIS Navigator. MMPK’s will expire quarterly and have a warning for the user at that time but will still function afterwards. They are updated quarterly to ensure you have the most up to date data possible. These mobile map packages include the following national datasets along with others: Surface Management Agency, Public Land Survey System (PLSS), BLM Recreation Sites, National Conservation Lands, ESRI’s Navigation Basemap and Vector Tile Package. Last updated 20250321. Contact jlzimmer@blm.gov with any questions.

Background A "physiologically based pharmacokinetic" (PBPK) approach uses a realistic model of the animal to describe the pharmacokinetics. Previous PBPKs have been designed for specific solutes, required specification of a large number of parameters and have not been designed for general use. Methods This new PBPK program (PKQuest) includes a "Standardhuman" and "Standardrat" data set so that the user input is minimized. It has a simple user interface, graphical output and many new features: 1) An option that uses the measured plasma concentrations to solve for the time course of the gastrointestinal, intramuscular, intraperotineal or skin absorption and systemic availability of a drug – for a general non-linear system. 2) Capillary permeability limitation defined in terms of the permeability-surface area products. 4) Saturable plasma and tissue protein binding. 5) A lung model that includes perfusion-ventilation mismatch. 6) A general optimization routine using either a global (simulated annealing) or local (Powell) minimization applicable to all model parameters. Results PKQuest was applied to measurements of human propranolol pharmacokinetics and intestinal absorption. A meal has two effects: 1) increases portal blood flow by 50%; and 2) decreases liver metabolism by 20%. There is a significant delay in the oval propranolol absorption in fasting subjects that is absent in fed subjects. The oral absorption of the long acting form of propranolol continues for a period of more than 24 hours. Conclusions PKQuest provides a new general purpose, easy to use, freely distributed and physiologically rigorous PBPK software routine.

Mobile Map Packages (MMPK’s) can be used in the ESRI Field Maps app (no login required), either by direct download in the Field Maps app or by sideloading from your PC. They can also be used in desktop applications that support MMPK’s such as ArcGIS Pro, and ArcGIS Navigator. MMPK’s will expire quarterly and have a warning for the user at that time but will still function afterwards. They are updated quarterly to ensure you have the most up to date data possible. These mobile map packages include the following national datasets along with others: Surface Management Agency, Public Land Survey System (PLSS), BLM Recreation Sites, National Conservation Lands, ESRI’s Navigation Basemap and Vector Tile Package. Last updated 20250321. Contact jlzimmer@blm.gov with any questions.

pyMCR is an open-source software library for performing multivariate curve resolution (MCR) analysis with an alternating regression scheme (MCR-AR). MCR is a chemometric method for elucidating signatures of analytes and their relative abundance from a series of mixture measurements, without any knowledge of these values a priori. This software library, written in Python, enables users to perform MCR analysis with their choice of constraints, regressors, and error functions to minimize. Further, users can apply different constraints and regressors for signature and abundance calculations. Finally, this library enables users to develop their own constraints, regressors, and error functions or import them from existing libraries.

Mobile Map Packages (MMPK’s) can be used in the ESRI Field Maps app (no login required), either by direct download in the Field Maps app or by sideloading from your PC. They can also be used in desktop applications that support MMPK’s such as ArcGIS Pro, and ArcGIS Navigator. MMPK’s will expire quarterly and have a warning for the user at that time but will still function afterwards. They are updated quarterly to ensure you have the most up to date data possible. These mobile map packages include the following national datasets along with others: Surface Management Agency, Public Land Survey System (PLSS), BLM Recreation Sites, National Conservation Lands, ESRI’s Navigation Basemap and Vector Tile Package. Last updated 20250321. Contact jlzimmer@blm.gov with any questions.

Mobile Map Packages (MMPK’s) can be used in the ESRI Field Maps app (no login required), either by direct download in the Field Maps app or by sideloading from your PC. They can also be used in desktop applications that support MMPK’s such as ArcGIS Pro, and ArcGIS Navigator. MMPK’s will expire quarterly and have a warning for the user at that time but will still function afterwards. They are updated quarterly to ensure you have the most up to date data possible. These mobile map packages include the following national datasets along with others: Surface Management Agency, Public Land Survey System (PLSS), BLM Recreation Sites, National Conservation Lands, ESRI’s Navigation Basemap and Vector Tile Package. Last updated 20250321. Contact jlzimmer@blm.gov with any questions.

Mobile Map Packages (MMPK’s) can be used in the ESRI Field Maps app (no login required), either by direct download in the Field Maps app or by sideloading from your PC. They can also be used in desktop applications that support MMPK’s such as ArcGIS Pro, and ArcGIS Navigator. MMPK’s will expire quarterly and have a warning for the user at that time but will still function afterwards. They are updated quarterly to ensure you have the most up to date data possible. These mobile map packages include the following national datasets along with others: Surface Management Agency, Public Land Survey System (PLSS), BLM Recreation Sites, National Conservation Lands, ESRI’s Navigation Basemap and Vector Tile Package. Last updated 20250321. Contact jlzimmer@blm.gov with any questions.

Mobile Map Packages (MMPK’s) can be used in the ESRI Field Maps app (no login required), either by direct download in the Field Maps app or by sideloading from your PC. They can also be used in desktop applications that support MMPK’s such as ArcGIS Pro, and ArcGIS Navigator. MMPK’s will expire quarterly and have a warning for the user at that time but will still function afterwards. They are updated quarterly to ensure you have the most up to date data possible. These mobile map packages include the following national datasets along with others: Surface Management Agency, Public Land Survey System (PLSS), BLM Recreation Sites, National Conservation Lands, ESRI’s Navigation Basemap and Vector Tile Package. Last updated 20250321. Contact jlzimmer@blm.gov with any questions.

Mobile Map Packages (MMPK’s) can be used in the ESRI Field Maps app (no login required), either by direct download in the Field Maps app or by sideloading from your PC. They can also be used in desktop applications that support MMPK’s such as ArcGIS Pro, and ArcGIS Navigator. MMPK’s will expire quarterly and have a warning for the user at that time but will still function afterwards. They are updated quarterly to ensure you have the most up to date data possible. These mobile map packages include the following national datasets along with others: Surface Management Agency, Public Land Survey System (PLSS), BLM Recreation Sites, National Conservation Lands, ESRI’s Navigation Basemap and Vector Tile Package. Last updated 20250321. Contact jlzimmer@blm.gov with any questions.

MetaMap is a highly configurable application developed by the Lister Hill National Center for Biomedical Communications at the National Library of Medicine (NLM) to map biomedical text to the UMLS Metathesaurus or, equivalently, to identify Metathesaurus concepts referred to in English text. MetaMap employs a knowledge-intensive approach, natural-language processing (NLP), and computational-linguistic techniques, and is used worldwide in industry and academia. At NLM, MetaMap is one of the foundations of NLM's Medical Text Indexer (MTI), which is applied to both semiautomatic and fully automatic indexing of biomedical literature. Technical documentation at http://metamap.nlm.nih.gov/#Downloads