Raw data to accompanying manuscript "The Pollutant Perfluorohexane Sulfonate (PFHxS) Reduces Serum Thyroxine but Does Not Alter Thyroid Hormone Action in the Postnatal Rat Brain". This dataset is associated with the following publication: O'Shaughnessy, K., K. Bell, A. Sasser, M. Gilbert, C. Riutta, J. Ford, J. McCord, and C. Wood. The Pollutant Perfluorohexane Sulfonate (PFHxS) Reduces Serum Thyroxine but Does Not Alter Thyroid Hormone Action in the Postnatal Rat Brain. ENVIRONMENT INTERNATIONAL. Elsevier B.V., Amsterdam, NETHERLANDS, 190: 108838, (2024).

180626 Thyroid Hormone PFOA PFOS Manuscript Data. This dataset is associated with the following publication: Selano, J., V. Richardson, J. Washington, and C. Mazur. Characterization of non-radiolabeled Thyroxine (T4) uptake in cryopreserved rat hepatocyte suspensions: Pharmacokinetic implications for PFOA and PFOS chemical exposure. TOXICOLOGY IN VITRO. Elsevier Science Ltd, New York, NY, USA, 58: 230-238, (2019).

This file contains summary data of thyroid hormones in serum and brain in rat dams and their pups following maternal exposure to a perflorinated substance, PFHxS and an antimicrobial, Triclosan. Gene expression in thyroid glands and liver and brain were investigated. Anatomical and bahavioral indices of developmental neurotoxicity were assessed. Result so fall of these inquiries are summarized in these datasets. This dataset is associated with the following publication: Gilbert, M.E., K. OShaughnessy, S. Thomas, C. Riutta, C. Wood, A. Smith, W. Oshiro, J. Ford, A. Hotchkiss, I. Hassan, and R.L. Ford. Thyroid Disruptors: Extrathyroidal Sites of Chemical Action and Neurodevelopmental Outcome-An Examination Using Triclosan and Perfluorohexane Sulfonate. TOXICOLOGICAL SCIENCES. Society of Toxicology, RESTON, VA, 183(6): 195-213, (2021).

This file contains summary data of thyroid hormones in serum and brain in rat dams and their pups following maternal exposure to a perflorinated substance, PFHxS and an antimicrobial, Triclosan. Gene expression in thyroid glands and liver and brain were investigated. Anatomical and bahavioral indices of developmental neurotoxicity were assessed. Result so fall of these inquiries are summarized in these datasets. This dataset is associated with the following publication: Gilbert, M.E., K. OShaughnessy, S. Thomas, C. Riutta, C. Wood, A. Smith, W. Oshiro, J. Ford, A. Hotchkiss, I. Hassan, and R.L. Ford. Thyroid Disruptors: Extrathyroidal Sites of Chemical Action and Neurodevelopmental Outcome-An Examination Using Triclosan and Perfluorohexane Sulfonate. TOXICOLOGICAL SCIENCES. Society of Toxicology, RESTON, VA, 183(6): 195-213, (2021).

thyroid hormones in serum and in brain were measured in fetal and neonatal rat cortex after graded levels of a thyroid hormone synthesis inhibitor were administered to pregnant rat dams. A number of gene targets were assessed to look for measures of thyroid hormone action in these same tissues. This dataset is associated with the following publication: OShaughnessy, K., C. Wood, R. Ford, P. Kosian, M. Hotchkiss, S. Degitz, and M. Gilbert. Thyroid hormone disruption in the fetal and neonatal rat: Predictive hormone measures and bioindicators of hormone action in the developing cortex- ToxSci. TOXICOLOGICAL SCIENCES. Society of Toxicology, RESTON, VA, 163-179, (2018).

Adequate levels of thyroid hormones (TH) are needed for proper brain development, deficiencies may lead to adverse neurological outcomes in humans and animal models. Environmental chemicals have been linked to TH disruption, yet the relationship between developmental exposures and decline in serum TH resulting in neurodevelopmental impairment is poorly understood. The present study developed a quantitative adverse outcome pathway (qAOP) where serum thyroxin (T4) reduction following inhibition of thyroperoxidase in the thyroid gland are described and related to deficits in fetal brain TH and the development of a brain malformation, subcortical band heterotopia. Pregnant dams were exposed to 6-propylthiouracil (PTU 0, 0.1, 0.5, 1, 2, or 3 ppm) from gestational day 6-20, increasing PTU concentrations in maternal thyroid gland and serum as well as in fetal serum. Dams exposed to 0.5 ppm PTU and higher exhibited dose-dependent decreases in thyroidal T4. Serum T4 levels in the dam were significantly decreased with exposure to 2 and 3 ppm PTU. In the fetus, T4 decrements were first observed at a lower dose of 0.5 ppm PTU. Based on these data, fetal brain T4 levels were estimated from published literature sources, and quantitatively linked to increases in the size of the heterotopia present in the brains of offspring. These data show the potential of in vivo assessments and computational descriptions of biological responses to predict the development of this structural brain malformation and use of qAOP approach to evaluate brain deficits that may result from exposure to other TH disruptors. This dataset is associated with the following publication: Hassan, I., H. El-Masri, P. Kosian, J. Ford, S. Degitz, and M. Gilbert. Neurodevelopment and Thyroid Hormone Synthesis Inhibition in the Rat: Quantitative Understanding Within the Adverse Outcome Pathway Framework. TOXICOLOGICAL SCIENCES. Society of Toxicology, 57-73, (2017).

Raw data accompanying "Thyroid Hormone Action Controls Multiple Components of Cell Junctions at the Ventricular Zone in the Newborn Rat Brain". This dataset is associated with the following publication: O'Shaughnessy, K., B. McMichael, A. Sasser, K. Bell, C. Riutta, J. Ford, T. Stoker, R. Grindstaff, A. Pandiri, and M. Gilbert. Thyroid Hormone Action Controls Multiple Components of Cell Junctions at the Ventricular Zone in the Newborn Rat Brain. Frontiers in Endocrinology. Frontiers, Lausanne, SWITZERLAND, 14: 1090081, (2023).

This dataset includes information on rat dam and pup bodyweights, thyroid hormone concentrations in serum, gene expression in brain, cell counts for cell proliferation in brain. This dataset is associated with the following publication: OShaughnessy, K., S. Thomas, S. Spring, J. Ford, R. Ford, and M. Gilbert. A transient window of hypothyroidism alters neural progenitor cells and results in abnormal brain development. Scientific Reports. Nature Publishing Group, London, UK, 1-14, (2019).

This dataset includes information on rat dam and pup bodyweights, thyroid hormone concentrations in serum, gene expression in brain, cell counts for cell proliferation in brain. This dataset is associated with the following publication: OShaughnessy, K., S. Thomas, S. Spring, J. Ford, R. Ford, and M. Gilbert. A transient window of hypothyroidism alters neural progenitor cells and results in abnormal brain development. Scientific Reports. Nature Publishing Group, London, UK, 1-14, (2019).

Data support each of the figures in Boyes et al., Moderate Perinatal Thyroid Hormone Insufficiency Alters Visual System Function in Adult Rats (to be submitted for publication). This dataset is associated with the following publication: Boyes, W., L. Degn, B. George, and M. Gilbert. Moderate Perinatal Thyroid Hormone Insufficiency Alters Visual System Function in Adult Rats. NEUROTOXICOLOGY. Elsevier B.V., Amsterdam, NETHERLANDS, 67: 73-83, (2018).