We conducted a systematic review/meta-analysis for epidemiologic evidence of the association between long-term criteria air pollution (nitrogen dioxide (NO2), sulfur dioxide (SO2), coarse particulate matter (PM10), fine particulate matter (PM2.5), ozone (O3), carbon monoxide (CO)) exposure and all-cause, respiratory, and sudden infant death syndrome (SIDS) infant mortality. This dataset is associated with the following publications: Wilkie, A., A. Krajewski, F. Njie, K. Park, S. Zelasky, K. Rappazzo, and T. Luben. Long-term exposure to criteria air pollutants and infant mortality: a systematic review and meta-analysis. INTERNATIONAL JOURNAL OF HYGIENE AND ENVIRONMENTAL HEALTH. Elsevier B.V., Amsterdam, NETHERLANDS, 267: 114587, (2025). Luben, T., A. Wilkie, A. Krajewski, F. Njie, K. Park, S. Zelasky, and K. Rappazzo. Systematic Review of Short-term Air Pollution Exposure and Infant Mortality. Presented at International Society for Environmental Epidemiology (ISEE) - North American Chapter, Corvallis, OR, USA, 06/19/2023 - 06/22/2023.

Dataset contains information on births in NC during the study period, linked with air pollutant concentrations during pregnancy periods, and index of neighborhood deprivation developed from US census 2000 and 2010 variables. This dataset is not publicly accessible because: EPA cannot release personally identifiable information regarding living individuals, according to the Privacy Act and the Freedom of Information Act (FOIA). This dataset contains information about human research subjects. Because there is potential to identify individual participants and disclose personal information, either alone or in combination with other datasets, individual level data are not appropriate to post for public access. Restricted access may be granted to authorized persons by contacting the party listed. It can be accessed through the following means: Birth data can be requested through the North Carolina Department of Health and Human Services website. Air pollution data is available through the EPA's RSIG gateway. Census data is available through the US Census website. Code will be provided on request to authors. Format: csv, SAS, and R files. This dataset is associated with the following publication: Cowan, K., A. Krajewski, M. Jimenez, T. Luben, L. Messer, and K. Rappazzo. Examining modification of the associations between air pollution and birth outcomes by neighborhood deprivation in a North Carolina birth cohort, 2011-2015. Frontiers in Reproductive Health. Frontiers, Lausanne, SWITZERLAND, 6(July): 1304749, (2024).

We conducted an unmatched case-control study of 1,225,285 infants from a North Carolina Birth Cohort (2003-2015). Ozone and PM2.5 during critical exposure periods (gestational weeks 3-8) were estimated using residential address and a national spatiotemporal model at census tract centroid. Here we describe data sources for outcome (i.e., congenital heart defects) and exposure (i.e., ozone and PM2.5) data. This dataset is not publicly accessible because: EPA cannot release personally identifiable information regarding living individuals, according to the Privacy Act and the Freedom of Information Act (FOIA). This dataset contains information about human research subjects. Because there is potential to identify individual participants and disclose personal information, either alone or in combination with other datasets, individual level data are not appropriate to post for public access. Restricted access may be granted to authorized persons by contacting the party listed. It can be accessed through the following means: The North Carolina Birth Cohort data are not publicly available as it contains personal identifiable information. Data may be requested through the NCDHHS, Division of Public Health with proper approvals. Air pollutant concentrations for ozone and PM2.5 from the national spatiotemporal model are publicly available from EPA's website. Format: Birth certificate data from the State Center for Health Statistics of the NC Department of Health and Human Services linked with data from the Birth Defects Monitoring Program (NC BDMP) to create a birth cohort of all infants born in NC between 2003-2015. The NC BDMP is an active surveillance system that follows NC births to obtain birth defect diagnoses up to 1 year after the date of birth as well as identify infant deaths during the first year of life and include relevant information from the death certificate. A national spatiotemporal model provided data on predicted ozone PM2.5 concentrations over critical prenatal and time periods. The prediction model used data from research and regulatory monitors as well as a large (>200) array of geographic covariates to create fine scale spatial and temporal predictions. The model has a cross-validated R2 of 0.89 for PM2.5. Concentrations were predicted for daily throughout the study period at the centroid of each 2010 census tract in NC. This dataset is associated with the following publication: Arogbokun, O., T. Luben, J. Stingone, L. Engel, C. Martin, and A. Olshan. Racial disparities in maternal exposure to ambient air pollution during pregnancy and prevalence of congenital heart defects. AMERICAN JOURNAL OF EPIDEMIOLOGY. Johns Hopkins Bloomberg School of Public Health, 194(3): 709-721, (2025).

These data are extracted from output from the Community Multiscale Air Quality (CMAQ) model run with inputs and simulations generated by the EQUATES project. Pollutant concentrations are pulled from the model gridcell corresponding to Baltimore, Maryland, where the measurements for this study were taken. This dataset is associated with the following publication: Sapkota, S., P. Shekhar, B. Murphy, H. Pye, C. Hennigan, and M. El-Sayed. Seasonal Assessment of Secondary Organic Aerosol Formed through Aqueous Pathways in the Eastern United States. ACS Earth and Space Chemistry. American Chemical Society, Washington, DC, USA, 9(4): 876-887, (2025).