data set has a description of the information in the excell file and all the data used in the study. This dataset is associated with the following publication: Gray, E., J. Conley, C. Lambright, and J. Furr. In utero exposure to a mixture of the perfluoroalkylisopropyl pesticide pyrifluquinazon with dibutyl phthalate cumulatively disrupts male rat reproductive development via different mechanisms of action. TOXICOLOGICAL SCIENCES. Society of Toxicology, RESTON, VA, 188(2): 234-247, (2022).

All summary data associated with manuscript figures and tables. This dataset is associated with the following publication: Conley, J., C. Lambright, N. Evans, M. Cardon, E. MedlockKakaley, V. Wilson, and E. Gray. A mixture of 15 phthalates and pesticides below individual chemical No Observed Adverse Effect Levels (NOAELs) produces reproductive tract malformations in the male rat. ENVIRONMENT INTERNATIONAL. Elsevier B.V., Amsterdam, NETHERLANDS, 156(106615): 1, (2021).

Dataset contains summary data (mean, standard error, sample size (n)) for all measured endpoints reported and depicted in the corresponding manuscript. This dataset is associated with the following publication: Conley, J., C. Lambright, N. Evans, M. Strynar, J. McCord, B. McIntyre, G. Travlos, M. Cardon, E. MedlockKakaley, P. Hartig, V. Wilson, and E. Gray. Adverse maternal, fetal, and postnatal effects of Hexafluoropropylene oxide dimer acid (GenX) from oral gestational exposure in Sprague Dawley rats. ENVIRONMENTAL HEALTH PERSPECTIVES. National Institute of Environmental Health Sciences (NIEHS), Research Triangle Park, NC, USA, 1-13, (2019).

Population-based estimates of pesticide intake are needed to characterize exposure for particular demographic groups based on their dietary behaviors. Regression modeling performed on measurements of selected pesticides in composited duplicate diet samples allowed 1) estimation of pesticide intakes for a defined demographic community, and 2) comparison of dietary pesticide intakes between the composite and individual samples. Extant databases were useful for assigning individual samples to composites, but they could not provide the breadth of information needed to facilitate measurable levels in every composite. Composite sample measurements were found to be good predictors of pyrethroid pesticide levels in their individual sample constituents where sufficient measurements are available above the method detection limit. Statistical inference shows little evidence of differences between individual and composite measurements and suggests that regression modeling of food groups based on composite dietary samples may provide an effective tool for estimating dietary pesticide intake for a defined population. This dataset is associated with the following publication: Michael, L., G.G. Brown, and L. Melnyk. Estimation of pyrethroid pesticide intake using regression modeling of food groups based on composite dietary samples... Journal of Environmental Science and Health. Part B, Pesticides, Food Contaminants, and Agricultural Wastes. Marcel Dekker Incorporated, New York, NY, USA, 51(11): 751, (2016).

Uploaded datasets are detailed exposure information (chemical concentrations and water quality parameters) for exposures conducted in a flow through diluter system with larval Pimephales promelas to four different pyrethroid pesticides. The GEO submission URL links to the NCBI GEO database and contains gene expression data from whole larvae exposed to different concentrations of the pyrethroids across multiple experiments. This dataset is associated with the following publication: Biales, A., M. Kostich, A. Batt, M. See, R. Flick, D. Gordon, J. Lazorchak, and D. Bencic. Initial Development of a Multigene Omics-Based Exposure Biomarker for Pyrethroid Pesticides. CRITICAL REVIEWS IN ENVIRONMENTAL SCIENCE AND TECHNOLOGY. CRC Press LLC, Boca Raton, FL, USA, 179(0): 27-35, (2016).

this file has the metadata sheet and the data used for the figures and tables in the PFQ vs BPC manuscript. This dataset is associated with the following publication: Gray, E., J. Furr, J. Conley, C. Lambright, N. Evans, M. Cardon, V. Wilson, P. Foster, and P. Hartig. A Conflicted Tale of Two Novel AR Antagonists In vitro and In vivo: Pyrifluquinazon versus Bisphenol C.. TOXICOLOGICAL SCIENCES. Society of Toxicology, RESTON, VA, 632-643, (2019).

We used systematic evidence map methods to summarize the available epidemiological and animal bioassay evidence for an expanded set of ~345 PFAS that were prioritized in 2019 by the EPA’s Center for Computational Toxicology and Exposure (CCTE) for in vitro toxicity and toxicokinetic screening. This work builds upon our previously published evidence map for ~150 PFAS chemicals (Carlson et al. 2022, https://doi.org/10.1289/EHP10343). This dataset is associated with the following publication: Shirke, A., E. Radke-Farabaugh, C. Lin, R. Blain, N. Vetter, c. lemeris, p. hartman, H. Hubbard, M. Angrish, X. Arzuaga Andino, J. Congleton, J. Davis, L. Dishaw, R. Jones, R. Judson, J. Kaiser, A. Kraft, L. Lizarraga, P. Noyes, G. Patlewicz, M. Taylor, A. Williams, K. Chialton, and L. Carlson. Expanded Systematic Evidence Map for Hundreds of Per- and Polyfluoroalkyl Substances (PFAS) and Comprehensive PFAS Human Health Dashboard. ENVIRONMENTAL HEALTH PERSPECTIVES. National Institute of Environmental Health Sciences (NIEHS), Research Triangle Park, NC, USA, 132(2): CID: 026001, (2024).

Data for individual animals used to create the information demonstrated in Table 1 of the manuscript, including PFESA BP2 serum and liver concentrations and serum clinical chemistry values. This dataset is associated with the following publication: Jenkins-Hill, D., M. Strynar, A. Lindstrom, A. Farthing, H. Huang, J. Schmid, J. Lang, and N. Chernoff. Toxicity of Balb-c mice exposed to recently identified 1,1,2,2-tetrafluoro-2-[1,1,1,2,3,3-hexafluoro-3-(1,1,2,2-tetrafluoroethoxy)propan-2-yl]oxyethane-1-sulfonic acid (PFESA-BP2). TOXICOLOGY. Elsevier Science Ltd, New York, NY, USA, 441(152529): 1, (2020).

Study reports for "Subchronic Toxicities of Four Per- and Polyfluoroalkyl Substances (PFASs) by Oral Exposure in Sprague–Dawley Rats". This dataset is associated with the following publication: Kenyon, E., M. Devito, G. Patlewicz, L. Adams, R. Thomas, J. Ambroso, X. Yang, J. Blake, B. Upadhyay, J. Furr, and M. Hughes. Subchronic Toxicities of Four Per- and Polyfluoroalkyl Substances (PFASs) by Oral Exposure in Sprague–Dawley Rats. Toxics. MDPI, Basel, SWITZERLAND, 13(7): 524, (2025).

Data includes disposition data of radiolabelled pyrethroids (bifenthrin, deltamethrin, cis-permethrin) following topical application. One dataset is the disposition of pyrethroid-derived radioactivity 24 hr post-application. The second dataset is the disposition of pyrethroid-derived radioactivity 120 hr post-application. This dataset is associated with the following publication: Hughes , M., and B. Edwards. In vivo dermal absorption of pyrethroid pesticides in the rat.. JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH. Taylor & Francis, Inc., Philadelphia, PA, USA, 79(2): 83-91, (2016).