Population-based estimates of pesticide intake are needed to characterize exposure for particular demographic groups based on their dietary behaviors. Regression modeling performed on measurements of selected pesticides in composited duplicate diet samples allowed 1) estimation of pesticide intakes for a defined demographic community, and 2) comparison of dietary pesticide intakes between the composite and individual samples. Extant databases were useful for assigning individual samples to composites, but they could not provide the breadth of information needed to facilitate measurable levels in every composite. Composite sample measurements were found to be good predictors of pyrethroid pesticide levels in their individual sample constituents where sufficient measurements are available above the method detection limit. Statistical inference shows little evidence of differences between individual and composite measurements and suggests that regression modeling of food groups based on composite dietary samples may provide an effective tool for estimating dietary pesticide intake for a defined population. This dataset is associated with the following publication: Michael, L., G.G. Brown, and L. Melnyk. Estimation of pyrethroid pesticide intake using regression modeling of food groups based on composite dietary samples... Journal of Environmental Science and Health. Part B, Pesticides, Food Contaminants, and Agricultural Wastes. Marcel Dekker Incorporated, New York, NY, USA, 51(11): 751, (2016).

Disposition of TBBPA-BDBPE following ex vivo application to rat or human skin, in vivo application to rat skin and estimated human in vivo from the ex vivo rat and human and in vivo rat data. This dataset is associated with the following publication: Knudsen, G., M. Hughes, and L. Birnbaum. Dermal disposition of Tetrabromobisphenol A Bis(2,3-dibromopropyl) ether (TBBPA-BDBPE) using rat and human skin. TOXICOLOGY LETTERS. Elsevier Science Ltd, New York, NY, USA, 301: 108-113, (2019).

The dataset includes mean +/- standard deviation of each experiment ex vitro (in vitro) rat, in vivo rat, ex vitro (in vitro) human, calculated human. The rows show each fraction or factor in the experiment (e.g., skin wash, tape strip, etc.). The ex vivo data is from work completed at EPA-RTP. The in vivo data was from work completed at NIEHS. This dataset is associated with the following publication: Knudsen, G., A. Trexler, A. Richiards, M. Hughes, and L. Birnbaum. 2,4,6-Tribromophenol disposition and kinetics in rodents: effects of dose, route, sex, and species. TOXICOLOGICAL SCIENCES. Society of Toxicology, RESTON, VA, 169(1): 167-179, (2019).

Gene expression microarray measurements in Pimephales promelas before and after pyrethroid exposure. This dataset is associated with the following publication: Kostich, M., D. Bencic, A. Batt, M. See, R. Flick, D. Gordon, J. Lazorchak, and A. Biales. Multigene Biomarkers of Pyrethroid Exposure: Exploratory Experiments. ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY. Society of Environmental Toxicology and Chemistry, Pensacola, FL, USA, 38(11): 2436-2466, (2019).

This manuscript tests the hypothesis of dose additivity of an environmental mixture of pyrethriod insecticides at the level of network function, in vitro. The results demonstrate that permethrin, deltamethrin, esfenvalerate, cypermethrin and beta-cyfluthrin all change the activity of networks as measured by microelectrode arrays, and that the effects of an environmental-relevant mixture of these 5 compounds can be predicted based on a dose-additivity model. These results are consistent with results from in vivo experiments that examined motor activity. This study supports the Office of Pesticides decision to regulate mixtures of pyrethroids based on dose additivity. This dataset is associated with the following publication: Johnstone , A., J. Strickland, K. Crofton , C. Gennings, and T. Shafer. Effects of an Environmentally-relevant Mixture of Pyrethroid Insecticides on Spontaneous Activity in Primary Cortical Networks on Microelectrode Arrays. NEUROTOXICOLOGY. Elsevier B.V., Amsterdam, NETHERLANDS, 60(16): 234-239, (2017).

Pyrethroid exposures and intake doses. This dataset is not publicly accessible because: EPA cannot release personally identifiable information regarding living individuals, according to the Privacy Act and the Freedom of Information Act (FOIA). This dataset contains information about human research subjects. Because there is potential to identify individual participants and disclose personal information, either alone or in combination with other datasets, individual level data are not appropriate to post for public access. Restricted access may be granted to authorized persons by contacting the party listed. It can be accessed through the following means: No contains PII, but all raw data have been provided in the paper (without PII). Format: Contains PII; however all raw data are provided in the paper (without PII). This dataset is associated with the following publication: Morgan, M. Dietary Pyrethroid Exposures and Intake Doses for 188 Duplicate-Single Solid Food Items Consumed by North Carolina Adults. Toxics. MDPI AG, Basel, SWITZERLAND, 8(1): 6, (2020).

N/A. This dataset is not publicly accessible because: EPA cannot release personally identifiable information regarding living individuals, according to the Privacy Act and the Freedom of Information Act (FOIA). This dataset contains information about human research subjects. Because there is potential to identify individual participants and disclose personal information, either alone or in combination with other datasets, individual level data are not appropriate to post for public access. Restricted access may be granted to authorized persons by contacting the party listed. It can be accessed through the following means: The data contain PII/CUI. However, all the raw food data (stripped of identifiers) used in this manuscript has been provided in a table, so the public can have access to all these data via a future open-access article. Format: N/A. This dataset is associated with the following publication: Morgan, M., D. MacMillan, D. Zehr, and J. Sobus. Pyrethroid insecticides and their environmental degradates in repeated duplicate-diet solid food samples of 50 adults. Journal of Exposure Science and Environmental Epidemiology. Nature Publishing Group, London, UK, 28: 40-45, (2018).

180626 Thyroid Hormone PFOA PFOS Manuscript Data. This dataset is associated with the following publication: Selano, J., V. Richardson, J. Washington, and C. Mazur. Characterization of non-radiolabeled Thyroxine (T4) uptake in cryopreserved rat hepatocyte suspensions: Pharmacokinetic implications for PFOA and PFOS chemical exposure. TOXICOLOGY IN VITRO. Elsevier Science Ltd, New York, NY, USA, 58: 230-238, (2019).

Decontamination studies evaluated the effectiveness of liquid-based surface decontaminants against pesticides on indoor surfaces. Building materials, representing nonporous and porous surfaces, were contaminated with common pesticides, including malathion, carbaryl, fipronil, deltamethrin, and permethrin as well as commercial formulations thereof. Pesticide surface concentrations were representative of the pesticide-specific levels measured during field investigations involving misapplications of pesticides in homes or businesses (25–2,400 µg/100 cm2 surface concentration range). Decontamination testing occurred via a single or repeated application of the decontaminant without further mechanical removal or rinse steps. Decontaminants were both off-the-shelf and specialized solutions representing various chemistries (hypochlorite, hydrogen peroxide, quaternary ammonium compounds and ammonium salts). The persistence of surface residues was also investigated to assess the potential reduction of pesticide mass on surfaces under simulated indoor environmental conditions. The datasets provide the pesticide mass recovered from coupons and the calculated decontamination efficacies for all decontamination studies. This dataset is associated with the following publication: Oudejans, L., A. Mysz, E. Snyder, B. Wyrzykowska-Ceradini, J. Nardin, D. Tabor, J. Starr, D. Stout, and P. Lemieux. Remediating Indoor Pesticide Contamination from Improper Pest Control Treatments: Persistence and Decontamination Studies. D.Aga JOURNAL OF HAZARDOUS MATERIALS. Elsevier Science Ltd, New York, NY, USA, 397(5): 11, (2020).

Rubbertown Passive VOC Dataset. This dataset is associated with the following publication: Mukerjee, S., L. Smith, E. Thoma, D. Whitaker, K. Oliver, R. Duvall, and T. Cousett. Spatial analysis of volatile organic compounds using passive samplers in the Rubbertown industrial area of Louisville, Kentucky, USA. Atmospheric Pollution Research. Turkish National Committee for Air Pollution Research and Control, Izmir, TURKEY, issue}: 81-86, (2020).