246-TBP dermal summary data

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The dataset includes mean +/- standard deviation of each experiment ex vitro (in vitro) rat, in vivo rat, ex vitro (in vitro) human, calculated human. The rows show each fraction or factor in the experiment (e.g., skin wash, tape strip, etc.). The ex vivo data is from work completed at EPA-RTP. The in vivo data was from work completed at NIEHS. This dataset is associated with the following publication: Knudsen, G., A. Trexler, A. Richiards, M. Hughes, and L. Birnbaum. 2,4,6-Tribromophenol disposition and kinetics in rodents: effects of dose, route, sex, and species. TOXICOLOGICAL SCIENCES. Society of Toxicology, RESTON, VA, 169(1): 167-179, (2019).

Hughes A-0gb9 EH-TBB and BEH-TEBP in vitro dermal absorption 05/24/2017

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The data is on 4 tabs, separated by species (rat, human) and chemical (EH-TBB and BEH_TEBP). The data is by cell (2-4/skin), and includes %dose in receptor fluid over time, % unabsorbed, % absorbed and % penetrated. This dataset is associated with the following publication: Knudsen, G., M. Hughes, J.M. Sanders, S. Hall, and L. Birnbaum. Estimation of human percutaneous bioavailability for two novel brominated flame retardants, 2-ethylhexyl tetrabromobenzoate (EH-TBB) and bis(2-ethylhexyl) tetrabromophthalate (BEH-TEBP), using the parallelogram approach. TOXICOLOGY AND APPLIED PHARMACOLOGY. Academic Press Incorporated, Orlando, FL, USA, 311: 117-127, (2016).

Hughes A-0gb9 EH-TBB and BEH-TEBP in vitro dermal absorption 05/24/2017

공공데이터포털

The data is on 4 tabs, separated by species (rat, human) and chemical (EH-TBB and BEH_TEBP). The data is by cell (2-4/skin), and includes %dose in receptor fluid over time, % unabsorbed, % absorbed and % penetrated. This dataset is associated with the following publication: Knudsen, G., M. Hughes, J.M. Sanders, S. Hall, and L. Birnbaum. Estimation of human percutaneous bioavailability for two novel brominated flame retardants, 2-ethylhexyl tetrabromobenzoate (EH-TBB) and bis(2-ethylhexyl) tetrabromophthalate (BEH-TEBP), using the parallelogram approach. TOXICOLOGY AND APPLIED PHARMACOLOGY. Academic Press Incorporated, Orlando, FL, USA, 311: 117-127, (2016).

Tetrabromobisphenol A In vitro Dermal Absopriton Data

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In vitro dermal absorption data of tetrabromobisphenol A using human cadaver and rat skin. This dataset is associated with the following publication: Knudsen, G., M. Hughes , K.L. McIntosh, J.M. Sanders, and L.S. Birnbaum. Estimation of Tetrabromobisphenol A (TBBPA)percutaneous uptake in humans using the parallelogram method.. TOXICOLOGY AND APPLIED PHARMACOLOGY. Academic Press Incorporated, Orlando, FL, USA, 289(2): 323-329, (2015).

Reference Data Set of Human Skin Reflectance

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This data set contains 100 reference reflectance spectra of human skin, spanning the wavelength region from 250 nm to 2500 nm. The spectra were acquired with a commercially available spectrophotometer and are directly traceable to the national scale for directional-hemispherical reflectance factor.

RAIDAR-ICE manuscript data

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Data from which figures and table in "A Model for Risk-Based Screening and Prioritization of Human Exposure to Chemicals from Near-Field Sources" were constructed. This dataset is associated with the following publication: Li, L., J. Westgate, L. Hughes, X. Zhang, B. Givehchi, L. Toose, J. Armitage, F. Wania, P. Egeghy, and J. Arnot. A Model for Risk-Based Screening and Prioritization of Human Exposure to Chemicals from Near-Field Sources. ENVIRONMENTAL SCIENCE & TECHNOLOGY. American Chemical Society, Washington, DC, USA, 52(24): 14235-14244, (2018).

Dermal metafile for six studies for permeability estimation

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Dermal absorption is an important route of exposure that includes pharmaceuticals, consumer products and occupational exposures. "httk" is being developed as a tool to predict internal dose after exposure. The dermal route will be added to this package in order to account for dermal exposure. This dataset is associated with the following publication: Evans, M., T. Moxon, G. Lian, B. Deacon, T. Chen, L. Adams, A. Meade, and J. Wambaugh. A regression analysis using simple descriptors for multiple dermal datasets: Going from individual membranes to the full skin. JOURNAL OF APPLIED TOXICOLOGY. John Wiley & Sons, Ltd., Indianapolis, IN, USA, 43(6): 940-950, (2023).

Reconstructing population exposures to acrylamide from human monitoring data using a pharmacokinetic framework dataset

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Publicly available dataset containing chemical exposure data. This dataset is associated with the following publication: Lin, Y., V. Morozov, A. Kadry, J. Caffrey , and W. Chou. Reconstructing population exposures to acrylamide from human monitoring data using a pharmacokinetic framework. CHEMOSPHERE. Elsevier Science Ltd, New York, NY, USA, 331: 138798, (2023).

In vitro dermal absorption of decabromodiphenyl ethane in rat and human skin

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In vitro dermal absorption of decabromodiphenyl ethane in rat and human skin. This dataset is associated with the following publication: Knudsen, G., J.M. Sanders, M. Hughes, E. Hull, and L. Birnbaum. The biological fate of decabromodiphenyl ethane following oral, dermal or intravenous administration. XENOBIOTICA. Taylor & Francis, Inc., Philadelphia, PA, USA, 47(10): 894-902, (2017).

ORD-017311 Data Brown DermPerm.xlsx

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List of chemicals used for model evaluation, their MW, log KOW, and references for the original data source(s), the review(s) the data was collected from, and reference for log KOW as cited in the reviews. [Table SI-3 of research article]. This dataset is associated with the following publication: Brown, T., J. Armitage, P. Egeghy, I. Kircanski, and J. Arnot. Dermal permeation data and models for the prioritization and screening-level exposure assessment of organic chemicals. ENVIRONMENT INTERNATIONAL. Elsevier Science Ltd, New York, NY, USA, 94: 424-435, (2016).