ORD-017311 Data Brown DermPerm.xlsx

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List of chemicals used for model evaluation, their MW, log KOW, and references for the original data source(s), the review(s) the data was collected from, and reference for log KOW as cited in the reviews. [Table SI-3 of research article]. This dataset is associated with the following publication: Brown, T., J. Armitage, P. Egeghy, I. Kircanski, and J. Arnot. Dermal permeation data and models for the prioritization and screening-level exposure assessment of organic chemicals. ENVIRONMENT INTERNATIONAL. Elsevier Science Ltd, New York, NY, USA, 94: 424-435, (2016).

Dermal metafile for six studies for permeability estimation

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Dermal absorption is an important route of exposure that includes pharmaceuticals, consumer products and occupational exposures. "httk" is being developed as a tool to predict internal dose after exposure. The dermal route will be added to this package in order to account for dermal exposure. This dataset is associated with the following publication: Evans, M., T. Moxon, G. Lian, B. Deacon, T. Chen, L. Adams, A. Meade, and J. Wambaugh. A regression analysis using simple descriptors for multiple dermal datasets: Going from individual membranes to the full skin. JOURNAL OF APPLIED TOXICOLOGY. John Wiley & Sons, Ltd., Indianapolis, IN, USA, 43(6): 940-950, (2023).

246-TBP dermal summary data

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The dataset includes mean +/- standard deviation of each experiment ex vitro (in vitro) rat, in vivo rat, ex vitro (in vitro) human, calculated human. The rows show each fraction or factor in the experiment (e.g., skin wash, tape strip, etc.). The ex vivo data is from work completed at EPA-RTP. The in vivo data was from work completed at NIEHS. This dataset is associated with the following publication: Knudsen, G., A. Trexler, A. Richiards, M. Hughes, and L. Birnbaum. 2,4,6-Tribromophenol disposition and kinetics in rodents: effects of dose, route, sex, and species. TOXICOLOGICAL SCIENCES. Society of Toxicology, RESTON, VA, 169(1): 167-179, (2019).

A compartment model to predict in vitro finite dose absorption of chemicals by human skin

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Supplementary data for "H.A. Fisher, M.V. Evans, A.L. Bunge, E.A. Cohen Hubal, D.A. Vallero, A compartment model to predict in vitro finite dose absorption of chemicals by human skin, Chemosphere, Volume 349, 2024, 140689, ISSN 0045-6535, https://doi.org/10.1016/j.chemosphere.2023.140689.". This dataset is associated with the following publication: Fisher, H., M. Evans, A. Bunge, E. Cohen-Hubal, and D. Vallero. A compartment model to predict in vitro finite dose absorption of chemicals by human skin. CHEMOSPHERE. Elsevier Science Ltd, New York, NY, USA, 349: 140689, (2024).

Non‐animal assessment of skin sensitization hazard: Is an integrated testing strategy needed, and if so what should be integrated?

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Appendix Skin sensitization data and non‐animal test data for 271 chemicals. This dataset is associated with the following publication: Roberts, D., and G. Patlewicz. Non‐animal assessment of skin sensitization hazard: Is an integrated testing strategy needed, and if so what should be integrated?. JOURNAL OF APPLIED TOXICOLOGY. John Wiley & Sons, Ltd., Indianapolis, IN, USA, 38(1): 41-50, (2017).

Hughes A-0gb9 EH-TBB and BEH-TEBP in vitro dermal absorption 05/24/2017

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The data is on 4 tabs, separated by species (rat, human) and chemical (EH-TBB and BEH_TEBP). The data is by cell (2-4/skin), and includes %dose in receptor fluid over time, % unabsorbed, % absorbed and % penetrated. This dataset is associated with the following publication: Knudsen, G., M. Hughes, J.M. Sanders, S. Hall, and L. Birnbaum. Estimation of human percutaneous bioavailability for two novel brominated flame retardants, 2-ethylhexyl tetrabromobenzoate (EH-TBB) and bis(2-ethylhexyl) tetrabromophthalate (BEH-TEBP), using the parallelogram approach. TOXICOLOGY AND APPLIED PHARMACOLOGY. Academic Press Incorporated, Orlando, FL, USA, 311: 117-127, (2016).

The chemical landscape of high-throughput new approach methodologies for exposure

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Data for the publication Isaacs, K.K., Egeghy, P., Dionisio, K.L. et al. The chemical landscape of high-throughput new approach methodologies for exposure. J Expo Sci Environ Epidemiol (2022). https://doi.org/10.1038/s41370-022-00496-9. This dataset is associated with the following publication: Isaacs, K., P. Egeghy, K. Dionisio, K. Phillips, A. Zidek, C. Ring, J. Sobus, E. Ulrich, B. Wetmore, A. Williams, and J. Wambaugh. The chemical landscape of high-throughput new approach methodologies for exposure. Journal of Exposure Science and Environmental Epidemiology. Nature Publishing Group, London, UK, 32: 820-832, (2022).

Low level hydrogen peroxide vapor data for Cary test house decontamination study, using a Bacillus anthracis surrogate

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The data set is comprised of five Excel spreadsheets, one for each of the tests described in the research article. The data in the spreadsheets are the colony forming unit (CFU) data for each coupon material replicate and location. This dataset is associated with the following publication: Mickelsen, L., J. Wood, W. Calfee, S. Serre, S. Ryan, A. Touati, F. Delafield, and D. Aslett. Low‐concentration hydrogen peroxide decontamination for Bacillus spore contamination in buildings. Remediation Journal. John Wiley & Sons, Inc., Hoboken, NJ, USA, 30(1): 47-56, (2019).

Tetrabromobisphenol A In vitro Dermal Absopriton Data

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In vitro dermal absorption data of tetrabromobisphenol A using human cadaver and rat skin. This dataset is associated with the following publication: Knudsen, G., M. Hughes , K.L. McIntosh, J.M. Sanders, and L.S. Birnbaum. Estimation of Tetrabromobisphenol A (TBBPA)percutaneous uptake in humans using the parallelogram method.. TOXICOLOGY AND APPLIED PHARMACOLOGY. Academic Press Incorporated, Orlando, FL, USA, 289(2): 323-329, (2015).