Hughes A-0gb9 EH-TBB and BEH-TEBP in vitro dermal absorption 05/24/2017

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The data is on 4 tabs, separated by species (rat, human) and chemical (EH-TBB and BEH_TEBP). The data is by cell (2-4/skin), and includes %dose in receptor fluid over time, % unabsorbed, % absorbed and % penetrated. This dataset is associated with the following publication: Knudsen, G., M. Hughes, J.M. Sanders, S. Hall, and L. Birnbaum. Estimation of human percutaneous bioavailability for two novel brominated flame retardants, 2-ethylhexyl tetrabromobenzoate (EH-TBB) and bis(2-ethylhexyl) tetrabromophthalate (BEH-TEBP), using the parallelogram approach. TOXICOLOGY AND APPLIED PHARMACOLOGY. Academic Press Incorporated, Orlando, FL, USA, 311: 117-127, (2016).

246-TBP dermal summary data

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The dataset includes mean +/- standard deviation of each experiment ex vitro (in vitro) rat, in vivo rat, ex vitro (in vitro) human, calculated human. The rows show each fraction or factor in the experiment (e.g., skin wash, tape strip, etc.). The ex vivo data is from work completed at EPA-RTP. The in vivo data was from work completed at NIEHS. This dataset is associated with the following publication: Knudsen, G., A. Trexler, A. Richiards, M. Hughes, and L. Birnbaum. 2,4,6-Tribromophenol disposition and kinetics in rodents: effects of dose, route, sex, and species. TOXICOLOGICAL SCIENCES. Society of Toxicology, RESTON, VA, 169(1): 167-179, (2019).

In vitro dermal absorption of decabromodiphenyl ethane in rat and human skin

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In vitro dermal absorption of decabromodiphenyl ethane in rat and human skin. This dataset is associated with the following publication: Knudsen, G., J.M. Sanders, M. Hughes, E. Hull, and L. Birnbaum. The biological fate of decabromodiphenyl ethane following oral, dermal or intravenous administration. XENOBIOTICA. Taylor & Francis, Inc., Philadelphia, PA, USA, 47(10): 894-902, (2017).

In vitro dermal absorption of decabromodiphenyl ethane in rat and human skin

공공데이터포털

In vitro dermal absorption of decabromodiphenyl ethane in rat and human skin. This dataset is associated with the following publication: Knudsen, G., J.M. Sanders, M. Hughes, E. Hull, and L. Birnbaum. The biological fate of decabromodiphenyl ethane following oral, dermal or intravenous administration. XENOBIOTICA. Taylor & Francis, Inc., Philadelphia, PA, USA, 47(10): 894-902, (2017).

Dermal metafile for six studies for permeability estimation

공공데이터포털

Dermal absorption is an important route of exposure that includes pharmaceuticals, consumer products and occupational exposures. "httk" is being developed as a tool to predict internal dose after exposure. The dermal route will be added to this package in order to account for dermal exposure. This dataset is associated with the following publication: Evans, M., T. Moxon, G. Lian, B. Deacon, T. Chen, L. Adams, A. Meade, and J. Wambaugh. A regression analysis using simple descriptors for multiple dermal datasets: Going from individual membranes to the full skin. JOURNAL OF APPLIED TOXICOLOGY. John Wiley & Sons, Ltd., Indianapolis, IN, USA, 43(6): 940-950, (2023).

Dermal metafile for six studies for permeability estimation

공공데이터포털

Dermal absorption is an important route of exposure that includes pharmaceuticals, consumer products and occupational exposures. "httk" is being developed as a tool to predict internal dose after exposure. The dermal route will be added to this package in order to account for dermal exposure. This dataset is associated with the following publication: Evans, M., T. Moxon, G. Lian, B. Deacon, T. Chen, L. Adams, A. Meade, and J. Wambaugh. A regression analysis using simple descriptors for multiple dermal datasets: Going from individual membranes to the full skin. JOURNAL OF APPLIED TOXICOLOGY. John Wiley & Sons, Ltd., Indianapolis, IN, USA, 43(6): 940-950, (2023).

RAIDAR-ICE manuscript data

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Data from which figures and table in "A Model for Risk-Based Screening and Prioritization of Human Exposure to Chemicals from Near-Field Sources" were constructed. This dataset is associated with the following publication: Li, L., J. Westgate, L. Hughes, X. Zhang, B. Givehchi, L. Toose, J. Armitage, F. Wania, P. Egeghy, and J. Arnot. A Model for Risk-Based Screening and Prioritization of Human Exposure to Chemicals from Near-Field Sources. ENVIRONMENTAL SCIENCE & TECHNOLOGY. American Chemical Society, Washington, DC, USA, 52(24): 14235-14244, (2018).

RAIDAR-ICE manuscript data

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Data from which figures and table in "A Model for Risk-Based Screening and Prioritization of Human Exposure to Chemicals from Near-Field Sources" were constructed. This dataset is associated with the following publication: Li, L., J. Westgate, L. Hughes, X. Zhang, B. Givehchi, L. Toose, J. Armitage, F. Wania, P. Egeghy, and J. Arnot. A Model for Risk-Based Screening and Prioritization of Human Exposure to Chemicals from Near-Field Sources. ENVIRONMENTAL SCIENCE & TECHNOLOGY. American Chemical Society, Washington, DC, USA, 52(24): 14235-14244, (2018).

A compartment model to predict in vitro finite dose absorption of chemicals by human skin

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Supplementary data for "H.A. Fisher, M.V. Evans, A.L. Bunge, E.A. Cohen Hubal, D.A. Vallero, A compartment model to predict in vitro finite dose absorption of chemicals by human skin, Chemosphere, Volume 349, 2024, 140689, ISSN 0045-6535, https://doi.org/10.1016/j.chemosphere.2023.140689.". This dataset is associated with the following publication: Fisher, H., M. Evans, A. Bunge, E. Cohen-Hubal, and D. Vallero. A compartment model to predict in vitro finite dose absorption of chemicals by human skin. CHEMOSPHERE. Elsevier Science Ltd, New York, NY, USA, 349: 140689, (2024).

In vivo dermal absorption of pyrethroid pesticides in the rat

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Data includes disposition data of radiolabelled pyrethroids (bifenthrin, deltamethrin, cis-permethrin) following topical application. One dataset is the disposition of pyrethroid-derived radioactivity 24 hr post-application. The second dataset is the disposition of pyrethroid-derived radioactivity 120 hr post-application. This dataset is associated with the following publication: Hughes , M., and B. Edwards. In vivo dermal absorption of pyrethroid pesticides in the rat.. JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH. Taylor & Francis, Inc., Philadelphia, PA, USA, 79(2): 83-91, (2016).