Brainstem Auditory Evoked Potential, Peripheral Nerve Action Potentials/NCV, Somatosensory Evoked Potentials (Cortex, Cerebellum) from adult male Long-Evans rats developmentally exposed to emamectin.

Contains nerve excitability data (tail and foot CMAP, tail mixed nerve), compound nerve action potentials, nerve conduction velocity, cortical and cerebellar somatosensory evoked potentials after treatment with citronellal, 3,4-dichloro-1-butene, or benzyl bromoacetate. Contains extracted data and analysis. This dataset is associated with the following publication: Herr, D., G. Jung, K. McDaniel, R. LoPachin, B. Geohagen, A. Smith, and M. Huffstickler. IN VIVO NEUROPHYSIOLOGICAL ASSESSMENT OF IN SILICO PREDICTIONS OF NEUROTOXICITY: CITRONELLAL, 3,4-DICHLORO-1-BUTENE, AND BENZYL BROMOACETATE. NEUROTOXICOLOGY. Elsevier B.V., Amsterdam, NETHERLANDS, 90(1): 48-61, (2022).

Analog/Digital points for individual animal's average brainstem auditory evoked responses (BAERs) and a second file with the scored peak latencies and amplitudes from the BAERs.

Characterization of 100 chemicals for electrophillic potential using Hard and Soft Acid and Bases theory. The chemicals were ranked for electrophillic potential and a group of chemicals within a range of electrophillic values were identified as having properties similar to other neurotoxicants. This dataset is associated with the following publication: Melnikov, F., B. Geohagen, T. Gavin, R. LoPachin, P. Anastas, P. Coish, and D. Herr. Application of the Hard and Soft, Acids and Bases (HSAB) Theory as a Method to Predict Cumulative Neurotoxicity. NEUROTOXICOLOGY. Elsevier B.V., Amsterdam, NETHERLANDS, 79: 95-103, (2020).

Research interested in oxidative stress markers following exposure to VOCs. This dataset is associated with the following publication: Kodavanti , P., J. Royland , D.A. Moore-Smith, J. Beas, J. Richards , T. Beasley , P. Evansky , and P.J. Bushnell. Acute and Subchronic Toxicity of Inhaled Toluene in Male Long-Evans Rats: Oxidative Stress Markers in Brain. NEUROTOXICOLOGY. Elsevier B.V., Amsterdam, NETHERLANDS, 51: 10-19, (2015).

Mitochondrial bioenergetics changes in different brain regions related to effects from ozone with rats that have chronically exercised or have been continuously sedentary. Also includes immunohistochemistry data for glial markers in hypothalamus and hippocampus. This dataset is associated with the following publication: Valdez, M., J. Valdez, D. Freeborn, A. Johnstone, and P. Kodavanti. The Effects of Ozone Exposure and Sedentary Lifestyle on Neuronal Microglia and Mitochondrial Bioenergetics of Female Long-Evans Rats. TOXICOLOGY AND APPLIED PHARMACOLOGY. Academic Press Incorporated, Orlando, FL, USA, 408: 115254, (2020).

This data set was used for the manuscript titled "Ozone-induced Changes in Oxidative Stress Parameters in Brain regions of Adult, Middle-age, and Senescent Brown Norway Rats". It includes various biochemical endpoints and neurobehavior. This dataset is associated with the following publication: Kodavanti, P.R., M. Valdez, J. Richards, D. Agina-Obu, P. Phillips, K. Jarema, and U. Kodavanti. Ozone-induced changes in oxidative stress parameters in brain regions of adult, middle-age, and senescent Brown Norway rats. TOXICOLOGY AND APPLIED PHARMACOLOGY. Academic Press Incorporated, Orlando, FL, USA, 410: 115351, (2020).

This study was performed to determine the role of adrenal-derived stress hormones in mediating brain effects after ozone exposure. Sham and adrenalectomized rats were exposed to air or ozone for 4 hours and within 2 hours after exposure brain regions, hypothalamus and brainstem were isolated and circulating pituitary hormones were analyzed. Global gene expression was analysed in these two brain regions using Illumina mRNA sequencing platform and data were analyzed using various bioinformatics platforms. The resulting data are included in this manuscript. This dataset is associated with the following publication: Henriquez, A., J. House, S. Snow, C. Miller, M. Schladweiler, A. Astriab Fisher, H. Ren, M. Valdez, P. Kodavanti, and U. Kodavanti. Ozone-induced dysregulation of neuroendocrine axes requires adrenal-derived stress hormones. TOXICOLOGICAL SCIENCES. Society of Toxicology, RESTON, VA, 172(1): 38-50, (2019).