This study is a randomized trial to investigate whether dietary supplementation with fish oil or olive oil modulate respiratory and cardiovascular effects of acute exposure to ozone in a controlled exposure chamber in young healthy adults. The dataset contains all the data for the outcome variables. This dataset is associated with the following publication: Chen, H., H. Tong, W. Shen, T. Montilla, M. Case, M. Almond , H. Wells, N. Alexis , D. Peden , A. Rappold, D. Diazsanchez, R. Devlin, P. Bromberg , and J. Samet. Fish oil blunts lung function decrements induced by acute exposure to ozone in young healthy adults: A randomized trial. ENVIRONMENT INTERNATIONAL. Elsevier B.V., Amsterdam, NETHERLANDS, 167(107407): 1, (2022).

Dataset for a study examining the cardiovascular effects from acute ozone exposure in rats fed with fish oil or olive oil diets. This dataset is associated with the following publication: Tong, H., S. Snow, M.C. Schladweiler, G. Carswell, B. Chorley, and U. Kodavanti. Fish Oil and Olive Oil-Enriched Diets Alleviate Acute Ozone-induced Cardiovascular Effects in Rats. TOXICOLOGY AND APPLIED PHARMACOLOGY. Academic Press Incorporated, Orlando, FL, USA, 409: 115296, (2020).

This data set is broken up into 2 Excel files. In one file are all the data pertaining to the vascular and pulmonary effects of ozone exposure in rats fed either a normal diet or diet enriched with coconut oil, fish oil, or olive oil. The different tabs of the spreadsheet pertain to each figure or table found in the manuscript. This file was updated on 12/7/17 to reflect changes to Figure 3 in response to reviewers comments following submission to Toxicological Sciences. In the second file is all the data for Figure 8 pertaining to the global microRNA assessment. This dataset is associated with the following publication: Snow, S., W. Cheng, A. Henriquez, M. Hodge, V. Bass, G. Nelson, G. Carswell, J. Richards, M. Schladweiler, A. Ledbetter, B. Chorley, K. Gowdy, H. Tong, and U. Kodavanti. Ozone-Induced Vascular Contractility and Pulmonary Injury are Differentially Impacted by Diets Enriched with Coconut Oil, Fish Oil, and Olive Oil. TOXICOLOGICAL SCIENCES. Society of Toxicology, RESTON, VA, 163(1): 57-69, (2018).

This data set is broken up into 2 Excel files. In one file are all the data pertaining to the vascular and pulmonary effects of ozone exposure in rats fed either a normal diet or diet enriched with coconut oil, fish oil, or olive oil. The different tabs of the spreadsheet pertain to each figure or table found in the manuscript. This file was updated on 12/7/17 to reflect changes to Figure 3 in response to reviewers comments following submission to Toxicological Sciences. In the second file is all the data for Figure 8 pertaining to the global microRNA assessment. This dataset is associated with the following publication: Snow, S., W. Cheng, A. Henriquez, M. Hodge, V. Bass, G. Nelson, G. Carswell, J. Richards, M. Schladweiler, A. Ledbetter, B. Chorley, K. Gowdy, H. Tong, and U. Kodavanti. Ozone-Induced Vascular Contractility and Pulmonary Injury are Differentially Impacted by Diets Enriched with Coconut Oil, Fish Oil, and Olive Oil. TOXICOLOGICAL SCIENCES. Society of Toxicology, RESTON, VA, 163(1): 57-69, (2018).

The dataset contains data of air pollution, blood lipids, vascular injury markers, coagulation markers, and heart rate variability and repolarization markers. This dataset is associated with the following publication: Chen, H., S. Zhang, W. Shen, C. Salazar, A. Schneider, A. Rappold, D. Diazsanchez, R. Devlin, J. Samet, and H. Tong. Omega-3 Fatty Acids Attenuate Cardiovascular Effects of Short-term Exposure to Ambient Air Pollution. Particle and Fibre Toxicology. BioMed Central Ltd, London, UK, 19(12): 1, (2022).

The dataset contains data of air pollution, blood lipids, vascular injury markers, coagulation markers, and heart rate variability and repolarization markers. This dataset is associated with the following publication: Chen, H., S. Zhang, W. Shen, C. Salazar, A. Schneider, A. Rappold, D. Diazsanchez, R. Devlin, J. Samet, and H. Tong. Omega-3 Fatty Acids Attenuate Cardiovascular Effects of Short-term Exposure to Ambient Air Pollution. Particle and Fibre Toxicology. BioMed Central Ltd, London, UK, 19(12): 1, (2022).

In this study male Wistar Kyoto rats maintained on diets enriched with coconut, fish or olive oil were compared with animals receiving normal diet for 8 weeks. After 8 weeks of dietary regimen, and while on respective diets, animals were exposed to air or 0.8 ppm ozone for 4 hours per day for 2 consecutive days and necropsies were performed post air or ozone exposure within 2 hours. Body weights, food consumption and body composition were assessed during dietary regimen. At necropsy, livers were stained for lipids, serum lipids and metabolic hormones were assessed, and liver, muscle and adipose tissues are assessed for gene expression using targeted Illumina sequencing for selected genes. Based on reviewers comments during revision period, circulating n-3, n-6, n-9 and unsaturated fatty acids were assessed in the serum through collaboration with Jenifer I. Fenton and Travis Goeden, Michigan State University where samples were shipped for analysis of these lipids using mass spectrometry. These data were incorporated in the manuscript (Table 1) and part of figure 3. This dataset is associated with the following publication: Snow, S., A. Henriquez, W. Cheng, A. Fisher, B. Vallanat, M. Angrish, J. Richards, M.C. Schladweiler, C. Wood, H. Tong, and U. Kodavanti. Diets Enriched with Coconut, Fish, and Olive Oil Modify Peripheral Metabolic Effects of Ozone in Rats. TOXICOLOGY AND APPLIED PHARMACOLOGY. Academic Press Incorporated, Orlando, FL, USA, 410(1): 115337, (2020).

In this study male Wistar Kyoto rats maintained on diets enriched with coconut, fish or olive oil were compared with animals receiving normal diet for 8 weeks. After 8 weeks of dietary regimen, and while on respective diets, animals were exposed to air or 0.8 ppm ozone for 4 hours per day for 2 consecutive days and necropsies were performed post air or ozone exposure within 2 hours. Body weights, food consumption and body composition were assessed during dietary regimen. At necropsy, livers were stained for lipids, serum lipids and metabolic hormones were assessed, and liver, muscle and adipose tissues are assessed for gene expression using targeted Illumina sequencing for selected genes. Based on reviewers comments during revision period, circulating n-3, n-6, n-9 and unsaturated fatty acids were assessed in the serum through collaboration with Jenifer I. Fenton and Travis Goeden, Michigan State University where samples were shipped for analysis of these lipids using mass spectrometry. These data were incorporated in the manuscript (Table 1) and part of figure 3. This dataset is associated with the following publication: Snow, S., A. Henriquez, W. Cheng, A. Fisher, B. Vallanat, M. Angrish, J. Richards, M.C. Schladweiler, C. Wood, H. Tong, and U. Kodavanti. Diets Enriched with Coconut, Fish, and Olive Oil Modify Peripheral Metabolic Effects of Ozone in Rats. TOXICOLOGY AND APPLIED PHARMACOLOGY. Academic Press Incorporated, Orlando, FL, USA, 410(1): 115337, (2020).

In this study, we investigated effects of inhaled ozone exposure and high-cholesterol diet (HCD) in healthy Wistar and Wistar-derived Goto-Kakizaki (GK) rats, a non-obese model of type 2 diabetes. Male rats (4-week old) were fed normal diet or HCD for 12 weeks and then exposed to filtered air or 1.0 ppm ozone (6hrs/day) for 1 or 2 days. We examined pulmonary, vascular, hematology, and inflammatory responses after each exposure plus an 18-hr recovery period. This dataset is associated with the following publication: Snow, S., A. Henriquez, L. Thompson, C. Fisher, M.C. Schladweiler, C. Wood, and U. Kodavanti. Pulmonary and Vascular Effects of Acute Ozone Exposure in Diabetic Rats Fed an Atherogenic Diet. TOXICOLOGY AND APPLIED PHARMACOLOGY. Academic Press Incorporated, Orlando, FL, USA, 415(115430): 1, (2021).

The dataset contains a list of cardiac and vascular biomarkers that were obtained on each day a participant visited the EPA Human Studies Facility. It also contains ozone concentrations on those days, which are publicly available on the EPA AirNow website. This dataset is not publicly accessible because: The dataset pertains to human research. It can be accessed through the following means: Requests to access data should be sent to Robert Devlin at devlin.robert@epa.gov. Format: The metadata are in the form of spreadsheets with health endpoints listed in columns and each human participant listed as a row. Similar spreadsheets contain exposure information in columns and participants in rows. This dataset is associated with the following publication: Mirowsky, J., M. Carraway, R. Dhingra, H. Tong, L. Neas, D. Diaz-Sanchez, W. Cascio, M. Case, J. Crooks, E. Hauser, E. Dowdy, W. Krause, and R. Devlin. Ozone exposure is associated with acute changes in inflammation, fibrinolysis, and endothelial cell function in coronary artery disease patients. ENVIRONMENTAL HEALTH. Academic Press Incorporated, Orlando, FL, USA, 16: 126, (2017).