PubMed was searched for the terms microRNA and biomarker in addition to blood (blue), urine (orange), saliva (grey), or cerebrospinal fluid (yellow). The graph in the paper displays the number of total annual publications over the past 16 years and the actual numbers used generate this graph are in incuded in the attached spreadsheet. A near annual doubling of publications occurred from the years 2009 until 2015, whereas only a mere 4% increase in annual publications from 2015 until 2018 was noted. While a number of factors can contribute to these publication trends, this indicates an overall cooling of research interest in biofluid-based microRNA biomarker development. This dataset is associated with the following publication: Chorley, B., E. Atabakhsh, G. Doran, J. Gautier, H. Ellinger-Ziegelbauer, D. Jackson, T. Sharapova, P. Yuen, R. Church, P. Couttet, R. Froetschl, J. McDuffie, V. Martine, P. Pande, L. Peel, C. Rafferty, F. Simutis, and A. Harrill. Methodological considerations for measuring biofluid-based microRNA biomarkers. CRITICAL REVIEWS IN TOXICOLOGY. Taylor & Francis Group, London, UK, 51(3): 264-282, (2021).

Data in each figure of the publication are provided in different tabs of the excel spreadsheet. There were multiple concentrations tested, which are listed in the rows of the sheet. Each column is a different replicate. This dataset is associated with the following publication: Saavedra, L., K. Wallace, T. Freudenrich, M. Mall, W. Mundy, J. Davila, T. Shafer, M. Wernig, and D. Haag. Comparison of Acute Effects of Neurotoxic Compounds on Network Activity in Human and Rodent Neural Cultures. TOXICOLOGICAL SCIENCES. Society of Toxicology, RESTON, VA, 180(2): 295-312, (2021).

The publicly available data from other published papers is in the published manuscript (DOI provided). This dataset is associated with the following publication: Kopylev, L., M. Dzierlenga, Y. Lin, B. Nachman, E. Radke-Farabaugh, H. Ru, and D. Segal. Which prenatal biomarker is most appropriate for methylmercury dose-response for neurodevelopmental effects?. RISK ANALYSIS. Blackwell Publishing, Malden, MA, USA, 1-10, (2024).

These data are associated with the figures and tables presented in the manuscript "Early microRNA responses in rodent liver mediated by furan exposure establish dose thresholds for later adverse outcomes". Each spreadsheet contains the data for each Figure and metadata describes each column and/or row of data. For access to the smallRNA-seq files, please follow link provided and supply the reviewer key code "mjsnewymzlollmz".

These data are associated with the figures and tables presented in the manuscript "Early microRNA responses in rodent liver mediated by furan exposure establish dose thresholds for later adverse outcomes". Each spreadsheet contains the data for each Figure and metadata describes each column and/or row of data. For access to the smallRNA-seq files, please follow link provided and supply the reviewer key code "mjsnewymzlollmz".