Complete summary data (mean, error, sample size) for all figures and tables associated with the present manuscript, which characterizes maternal, fetal, and neonatal effects of oral exposure to HFPO-DA (GenX) during gestation in the Sprague-Dawley rat . This dataset is associated with the following publication: Conley, J., C. Lambright, N. Evans, J. McCord, M. Strynar, D. Hill, E. MedlockKakaley, V. Wilson, and E. Gray. Hexafluoropropylene oxide-dimer acid (HFPO-DA or GenX) alters maternal and fetal glucose and lipid metabolism and produces neonatal mortality, low birthweight and hepatomegaly in the Sprague-Dawley rat. ENVIRONMENT INTERNATIONAL. Elsevier B.V., Amsterdam, NETHERLANDS, 146: 106204, (2021).

Dataset includes summary statistics (mean, standard error, sample size) for all endpoints measured and reported in the experiments described in the published manuscript. This dataset is associated with the following publication: Conley, J., C. Lambright, N. Evans, A. Farraj, J. Smoot, R. Grindstaff, D. Jenkins-Hill, J. McCord, E. Medlock Kakaley, A. Dixon, E. Hines, and L. Gray. Dose additive maternal and offspring effects of oral maternal exposure to a mixture of three PFAS (HFPO-DA, NBP2, PFOS) during pregnancy in the Sprague-Dawley rat. SCIENCE OF THE TOTAL ENVIRONMENT. Elsevier BV, AMSTERDAM, NETHERLANDS, 892: 164609, (2023).

Dataset contains summary data (mean, standard error, sample size (n)) for all measured endpoints reported and depicted in the corresponding manuscript. This dataset is associated with the following publication: Conley, J., C. Lambright, N. Evans, M. Strynar, J. McCord, B. McIntyre, G. Travlos, M. Cardon, E. MedlockKakaley, P. Hartig, V. Wilson, and E. Gray. Adverse maternal, fetal, and postnatal effects of Hexafluoropropylene oxide dimer acid (GenX) from oral gestational exposure in Sprague Dawley rats. ENVIRONMENTAL HEALTH PERSPECTIVES. National Institute of Environmental Health Sciences (NIEHS), Research Triangle Park, NC, USA, 1-13, (2019).

Background Porphyria cutanea tarda (PCT) is caused by hexachlorobenzene (HCB) in several species of laboratory mammals, but the human evidence is contradictory. In a study among adults of a population highly exposed to HCB (Flix, Catalonia, Spain), the prevalence of PCT was not increased. We aimed at analysing the association of individual urinary porphyrins with the serum concentrations of HCB and other organochlorine compounds in this highly exposed population. Methods A cross-sectional study on total porphyrins was carried out in 1994 on 604 inhabitants of the general population of Flix, older than 14 years. Of them, 241 subjects (comprising a random sample and the subgroup with the highest exposure) were included for the present study. The porphyrin profile was determined by high-pressure liquid chromatography. Serum concentrations of HCB, as well as common organochlorine compounds, were determined by gas chromatography coupled to electron capture detection. Results Coproporphyrin I (CPI) and coproporphyrin III (CPIII) were the major porphyrins excreted, while uroporphyrins I and III were only detected in 2% and 36% of the subjects respectively, and heptaporphyrins I and III in 1% and 6%, respectively. CPI and CPIII decreased with increasing HCB concentrations (p < 0.05). This negative association was not explained by age, alcohol, smoking, or other organochlorine compounds. No association was found between uroporphyrin I and III excretion, nor heptaporphyrin excretion, and HCB. CPIII increased with smoking (p < 0.05). Conclusion HCB exposure in this highly exposed population did not increase urinary concentrations of individual porphyrins.

Study reports for "Subchronic Toxicities of Four Per- and Polyfluoroalkyl Substances (PFASs) by Oral Exposure in Sprague–Dawley Rats". This dataset is associated with the following publication: Kenyon, E., M. Devito, G. Patlewicz, L. Adams, R. Thomas, J. Ambroso, X. Yang, J. Blake, B. Upadhyay, J. Furr, and M. Hughes. Subchronic Toxicities of Four Per- and Polyfluoroalkyl Substances (PFASs) by Oral Exposure in Sprague–Dawley Rats. Toxics. MDPI, Basel, SWITZERLAND, 13(7): 524, (2025).

cell culture information with toxicity and proteomic changes. This dataset is associated with the following publication: VanEmon, J., P. Pan, and F. Van Breukelen. Effects of chlorpyrifos and trichloropyridinol on HEK 293 human embryonic kidney cells. CHEMOSPHERE. Elsevier Science Ltd, New York, NY, USA, 191: 537-547, (2018).

Data set 1 consists of the experimental data for the Wild Type and PPAR KO animal study and includes data used to prepare Figures 1-4 and Table 1 of the Das et al, 2016 paper. This dataset is associated with the following publication: Das, K., C. Wood, M. Lin, A.A. Starkov, C. Lau, K.B. Wallace, C. Corton, and B. Abbott. Perfluoroalky acids-induced liver steatosis: Effects on genes controlling lipid homeostasis. TOXICOLOGY. Elsevier Science Ltd, New York, NY, USA, 378: 32-52, (2017).

transformed raw data. This dataset is associated with the following publication: Kitchin, K., J. Richards, B. Robinette, K. Wallace, N. Coates, B. Castellon, E. Grulke, and J. Kou. Biochemical effects of some CeO2, SiO2, and TiO2 nanomaterials in HepG2 cells.. CELL BIOLOGY AND TOXICOLOGY. Springer, New York, NY, USA, 35(2): 129-145, (2019).

The files in this data release are RNA seq datafiles from a study that examined the effects of the synthetic anabolic steroid 17β hydroxyestra 4,9,11 trien-3-one, trenbolone (17βT - CAS 10161-33-8), a common contaminant of wastes from confined animal feeding operations (CAFOs). Japanese quail (Coturnix japonica) were exposed in the egg and through feed to multiple doses of 17βT and liver transcriptomes were examined to identify genes and pathways directly affected by this androgenic compound. RNA was extracted from liver of adults and embryos and analyzed (1x50 bp) on an Illumina HiSeq 2000. NCBI Biosample accessions and the raw counts that were input into the differential expression analysis are provided in this dataset. The raw sequence data are available at the NCBI Sequence Read Archive under Bioproject numbers PRJNA313918 and PRJNA313931.

This study examined effects of the brominated flame retardant hexabromocyclododecane (HBCD) on the avian endocrine system. Japanese quail (Coturnix japonica) were exposed to multiple doses of HBCD over multiple generations through feed and by maternal deposition into the egg. Liver transcriptomes were examined to identify genes and pathways directly affected by HBCD to better understand the mechanisms of action in birds. RNA was extracted from liver of adults and embryos and analyzed (1x50 bp) on an Illumina HiSeq 2000. NCBI Biosample accessions and the raw counts that were input into the differential expression analysis are provided in this dataset. The raw sequence data are available at the NCBI Sequence Read Archive under Bioproject number PRJNA313931.