Effects of developmental 17beta-estradiol exposure on microbiota and behavior in zebrafish. This dataset is associated with the following publication: Catron, T., A. Swank, L. Wehmas, D. Phelps, S. Keely, N. Brinkman, J. McCord, R. Singh, J. Sobus, C. Wood, M. Strynar, E. Wheaton, and T. Tal. Microbiota alter metabolism and mediate neurodevelopmental toxicity of 17β-estradiol. Scientific Reports. Nature Publishing Group, London, UK, 9: Article number 7064, (2019).

The following supporting information can be downloaded at: https://www.mdpi.com/article/10.3390/toxics10050256/s1. Figure S1, Effect of DMSO on Light/Dark Locomotor Activity; Figure S2, Time Course Behavioral Graph, Activity Box Plots and Developmental Toxicity for each Chemical; Table S1, Raw Data. This dataset is associated with the following publication: Jarema, K., D. Hunter, B. Hill, J. Olin, K. Britton, M. Waalkes, and S. Padilla. Developmental Neurotoxicity and Behavioral Screening in Larval Zebrafish with a Comparison to Other Published Results. Toxics. MDPI, Basel, SWITZERLAND, 10(5): 256, (2022).

The following supporting information can be downloaded at: https://www.mdpi.com/article/10.3390/toxics10050256/s1. Figure S1, Effect of DMSO on Light/Dark Locomotor Activity; Figure S2, Time Course Behavioral Graph, Activity Box Plots and Developmental Toxicity for each Chemical; Table S1, Raw Data. This dataset is associated with the following publication: Jarema, K., D. Hunter, B. Hill, J. Olin, K. Britton, M. Waalkes, and S. Padilla. Developmental Neurotoxicity and Behavioral Screening in Larval Zebrafish with a Comparison to Other Published Results. Toxics. MDPI, Basel, SWITZERLAND, 10(5): 256, (2022).

This file contains data used to generate figures shown in Catron et al. Characterization of host toxicity and microbiota disruption in larval zebrafish following developmental exposure to BPA and BPA alternatives. This dataset is associated with the following publication: Catron, T., S. Keely, N. Brinkman, T. Zurlinden, C. Wood, J. Wright, D. Phelps, E. Wheaton, A. Kvasnicka, S. Gaballah, R. Lamendella, and T. Tal. Host Developmental Toxicity of BPA and BPA Alternatives Is Inversely Related to Microbiota Disruption in Zebrafish. TOXICOLOGICAL SCIENCES. Society of Toxicology, RESTON, VA, 167(2): 468-483, (2019).

This file contains data used to generate figures shown in Catron et al. Characterization of host toxicity and microbiota disruption in larval zebrafish following developmental exposure to BPA and BPA alternatives. This dataset is associated with the following publication: Catron, T., S. Keely, N. Brinkman, T. Zurlinden, C. Wood, J. Wright, D. Phelps, E. Wheaton, A. Kvasnicka, S. Gaballah, R. Lamendella, and T. Tal. Host Developmental Toxicity of BPA and BPA Alternatives Is Inversely Related to Microbiota Disruption in Zebrafish. TOXICOLOGICAL SCIENCES. Society of Toxicology, RESTON, VA, 167(2): 468-483, (2019).

This dataset contains all underlying data used to generate the figures contained in Gaballah et al. Evaluation of developmental toxicity, developmental neurotoxicity, and tissue dose in zebrafish exposed to GenX and other PFAS. This dataset is associated with the following publication: Gaballah, S., A. Swank, X.M. Howey, J. Sobus, J. Schmid, T. Catron, J. McCord, E. Hines, and M. Strynar. Evaluation of developmental toxicity, developmental neurotoxicity, and tissue dose in zebrafish exposed to GenX and other PFAS. NA. NA (ed.), ENVIRONMENTAL HEALTH PERSPECTIVES. National Institute of Environmental Health Sciences (NIEHS), Research Triangle Park, NC, USA, 128(4): 047005-1 - 047005-22, (2020).

This dataset contains all underlying data used to generate the figures contained in Gaballah et al. Evaluation of developmental toxicity, developmental neurotoxicity, and tissue dose in zebrafish exposed to GenX and other PFAS. This dataset is associated with the following publication: Gaballah, S., A. Swank, X.M. Howey, J. Sobus, J. Schmid, T. Catron, J. McCord, E. Hines, and M. Strynar. Evaluation of developmental toxicity, developmental neurotoxicity, and tissue dose in zebrafish exposed to GenX and other PFAS. NA. NA (ed.), ENVIRONMENTAL HEALTH PERSPECTIVES. National Institute of Environmental Health Sciences (NIEHS), Research Triangle Park, NC, USA, 128(4): 047005-1 - 047005-22, (2020).

Across taxa, animals with depleted intestinal microbiomes show disrupted behavioral phenotypes. Axenic (i.e., microbe-free) mice, zebrafish, and fruit flies exhibit increased locomotor behavior, or hyperactivity. The mechanism through which bacteria interact with host cells to trigger normal neurobehavioral development in larval zebrafish is unknown. Here, we monoassociated zebrafish with either one of six different zebrafish-associated bacteria, mixtures of these host-associates, or with an environmental bacterial isolate. We found that while the axenic cohort was hyperactive, monoassociation with three different host-associated bacterial species, as well as with the mixtures, resulted in control-like locomotor behavior. Monoassociation with one host-associate and the environmental isolate resulted in the hyperactive phenotype characteristic of axenic larvae, while monoassociation with two other host-associated bacteria partially blocked this phenotype. Furthermore, we found an intriguing inverse relationship between the total concentration of bacteria per larvae and locomotor behavior. These data support a growing body of evidence that individual species of bacteria can have different effects on host behavior, potentially related to their success at intestinal colonization. Specific to the zebrafish model, our results suggest that differences in the composition of microbes in fish facilities could have profound effects on the outcomes of behavioral and pharmacological studies. This dataset is associated with the following publication: Weitekamp, C., A. Kvasnicka, S. Keely, N. Brinkman, X. Howey, S. Gaballah, D. Phelps, T. Catron, T. Zurlinden, E. Wheaton, and T. Tal. Monoassociation with bacterial isolates reveals the role of colonization, community complexity and abundance on locomotor behavior in larval zebrafish. Animal Microbiome. BioMed Central Ltd, London, UK, 3(12): 1-13, (2021).

Across taxa, animals with depleted intestinal microbiomes show disrupted behavioral phenotypes. Axenic (i.e., microbe-free) mice, zebrafish, and fruit flies exhibit increased locomotor behavior, or hyperactivity. The mechanism through which bacteria interact with host cells to trigger normal neurobehavioral development in larval zebrafish is unknown. Here, we monoassociated zebrafish with either one of six different zebrafish-associated bacteria, mixtures of these host-associates, or with an environmental bacterial isolate. We found that while the axenic cohort was hyperactive, monoassociation with three different host-associated bacterial species, as well as with the mixtures, resulted in control-like locomotor behavior. Monoassociation with one host-associate and the environmental isolate resulted in the hyperactive phenotype characteristic of axenic larvae, while monoassociation with two other host-associated bacteria partially blocked this phenotype. Furthermore, we found an intriguing inverse relationship between the total concentration of bacteria per larvae and locomotor behavior. These data support a growing body of evidence that individual species of bacteria can have different effects on host behavior, potentially related to their success at intestinal colonization. Specific to the zebrafish model, our results suggest that differences in the composition of microbes in fish facilities could have profound effects on the outcomes of behavioral and pharmacological studies. This dataset is associated with the following publication: Weitekamp, C., A. Kvasnicka, S. Keely, N. Brinkman, X. Howey, S. Gaballah, D. Phelps, T. Catron, T. Zurlinden, E. Wheaton, and T. Tal. Monoassociation with bacterial isolates reveals the role of colonization, community complexity and abundance on locomotor behavior in larval zebrafish. Animal Microbiome. BioMed Central Ltd, London, UK, 3(12): 1-13, (2021).

Data for Joan M. Hedge, et al., Influence of Methylene Blue or Dimethyl Sulfoxide on Larval Zebrafish Development and Behavior. Zebrafish. http://doi.org/10.1089/zeb.2023.0017. This dataset is associated with the following publication: Hedge, J., D. Hunter, E. Sanders, K. Jarema, J. Olin, K. Britton, M. Lowery, B. Knapp, S. Padilla, and B. Hill. Influence of Methylene Blue or Dimethyl Sulfoxide on Larval Zebrafish Development and Behavior. Zebrafish. Mary Ann Liebert, Inc., New Rochelle, NY, USA, 20(4): 132-145, (2023).