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ACTIVE VERSUS SEDENTARY LIFESTYLE FROM WEANING TO ADULTHOOD AND SUSCEPTIBILITY TO OZONE IN RATS
The prevalence of a sedentary (SED) life style combined with calorically rich diets has spurred the rise in childhood obesity which, in turn, translates to adverse health effects in adulthood. Obesity and lack of active (ACT) lifestyle may increase susceptibility to air pollutants. We housed 22 day-old female Long-Evans rats in a cage without (SED) or with a running wheel (ACT). After 10 weeks the rats ran 310 ± 16.3 km (SEM). Responses of SED and ACT rats to whole-body O3 (0, 0.25, 0.5, or 1.0 ppm; 5 hr/day for 2 days) was assessed. Glucose tolerance (GTT) was performed following the first day of O3. ACT rats had less body fat and an improved glucose tolerance (GTT). Ventilatory function (plethysmography) of SED and ACT groups was similarly impaired by O3. Bronchoalveolar lavage fluid (BALF) was collected after the second O3 exposure. SED and ACT rats were hyperglycemic following 1.0 ppm O3. GTT was impaired by O3 in both groups; however, ACT rats exhibited improved recovery to 0.25 and 1.0 ppm O3. BALF cell neutrophils and total cells were similarly increased in ACT and SED groups exposed to 1.0 ppm O3. O3-induced increase in eosinophils was exacerbated in SED rats. Chronic exercise from post-weaning to adulthood improved some of the metabolic and pulmonary responses to O3 (GTT and eosinophils) but several other parameters were unaffected. The reduction in O3-induced rise in BALF eosinophils in ACT rats suggests a possible link between a SED lifestyle and incidence of asthma-related symptoms from O3.  . This dataset is associated with the following publication: Gordon, C., P. Phillips, A. Ledbetter, S. Snow, M. Schladweiler, A. Johnstone, and U. Kodavanti. ACTIVE VS. SEDENTARY LIFESTYLE FROM WEANING TO ADULTHOOD AND SUSCEPTIBILITY TO OZONE IN RATS. INHALATION TOXICOLOGY. Informa Healthcare USA, New York, NY, USA, L100-L109, (2017).
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Pulmonary sensitivity to ozone exposure in sedentary versus chronically trained, female rats
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Pulmonary effects to ozone with rats that have chronically exercised or have been continuously sedentary. Also includes body composition of both groups throughout experimentation. This dataset is associated with the following publication: Gordon , C., P. Phillips , T. Beasley , A. Ledbetter , A. Cenk, U. Kodavanti , and A. Johnstone. Pulmonary Sensitivity to Ozone Exposure in Sedentary Versus Chronically Trained, Female Rats. INHALATION TOXICOLOGY. Informa Healthcare USA, New York, NY, USA, 293-302, (2016).
FASEB J Ozone HFD
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Data from Prenatal ozone exposure programs a sexually dimorphic susceptibility to high fat diet in adolescent Long-Evans rats. This dataset is associated with the following publication: Stewart, E., J. Dye, M. Schladweiler, P. Phillips, K. McDaniel, J. Richards, R. Grindstaff, W. Padgett, M. Moore, D. Jenkins-Hill, C. Gordon, U. Kodavanti, and C. Miller. Prenatal ozone exposure programs a sexually dimorphic susceptibility to high fat diet in adolescent Long-Evans rats.. FASEB JOURNAL. Federation of American Societies for Experimental Biology (FASEB), Bethesda, MD, USA, 36(12): e22664, (2022).
Maternal High Fat Diet Modify Offspring Susceptibility to Inhaled Ozone-Induced Systemic Metabolic Alterations
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Maternal high-fat diet (HFD) and obesity can increase the susceptibility of offspring to inhaled pollutants. In this study, we examined the influence of maternal HFD on metabolic responses to ozone in young Long-Evans rat offspring. F0-females began control (CD; 10%kcal from fat) or high-fat diet (HFD; 60%kcal from fat) at post-natal day (PND)-30. Rats were bred on PND-72 and allowed to give birth. Dietary regimen was maintained until PND-30 and then all offspring were switched to CD. On PND-40, female and male offspring-F1 (n=10/group) were exposed to air or 0.8-ppm ozone for 5h and within 1h serum samples were collected for neuroendocrine hormones and global metabolomic analysis. Offspring from HFD-dams had increased body fat and weight relative to CD, however, no major changes in circulating hormones were noted. Metabolomic analysis revealed significant sex, diet, and exposure-related changes in metabolites. Maternal HFD increased free fatty acids and decreased phospholipids (female>male). Also, microbiome-associated histidine and tyrosine metabolites were increased in both sexes of offspring, while 1,5-anhydroglucitol levels decreased in males. Ozone exposure increased free fatty acids in males from CD-dams but decreased in females from HFD-dams. Ozone also decreased monohydroxy fatty acids and acyl carnitines in females (HFD>CD). Moreover, it increased pyruvate along with TCA cycle intermediates in females suggesting an increase in glucose utilization. Ozone increased various amino acids, polyamines and metabolites of gut microbiota in HFD female offspring. Collectively, these data suggest that maternal HFD increases offspring susceptibility to metabolic alterations in a sex-specific manner when challenged with environmental stressors. This dataset is associated with the following publication: Snow, S., K. Broniowska, E. Karoly, A. Henriquez, P. Phillips, A. Ledbetter, M. Schladweiler, C. Miller, C. Gordon, and U. Kodavanti. Offspring Susceptibility to Metabolic Alterations Due to Maternal High Fat Diet and the Impact of Inhaled Ozone Used as a Stressor. Scientific Reports. Nature Publishing Group, London, UK, 1, (2020).
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