Evidence for a role of diet in asthma and chronic obstructive pulmonary disease (COPD) has been accumulating rapidly over the past decade. Associations have been reported between the intake of fruit, fish, antioxidant vitamins, fatty acids, sodium or magnesium, and indicators of asthma and COPD. Several issues need to be addressed before causality of these associations can be established. The role of diet in the development of disease and the induction time and reversibility of the effect needs further investigation. The role of smoking habits in the relation of diet and respiratory disease also needs to be elucidated. Nevertheless, based on the available evidence, dietary guidelines could be proposed for the primary and secondary prevention of asthma and COPD that are in line with existing dietary guidelines for the prevention of coronary heart disease and cancer.

Data from Prenatal ozone exposure programs a sexually dimorphic susceptibility to high fat diet in adolescent Long-Evans rats. This dataset is associated with the following publication: Stewart, E., J. Dye, M. Schladweiler, P. Phillips, K. McDaniel, J. Richards, R. Grindstaff, W. Padgett, M. Moore, D. Jenkins-Hill, C. Gordon, U. Kodavanti, and C. Miller. Prenatal ozone exposure programs a sexually dimorphic susceptibility to high fat diet in adolescent Long-Evans rats.. FASEB JOURNAL. Federation of American Societies for Experimental Biology (FASEB), Bethesda, MD, USA, 36(12): e22664, (2022).

In this study male Wistar Kyoto rats maintained on diets enriched with coconut, fish or olive oil were compared with animals receiving normal diet for 8 weeks. After 8 weeks of dietary regimen, and while on respective diets, animals were exposed to air or 0.8 ppm ozone for 4 hours per day for 2 consecutive days and necropsies were performed post air or ozone exposure within 2 hours. Body weights, food consumption and body composition were assessed during dietary regimen. At necropsy, livers were stained for lipids, serum lipids and metabolic hormones were assessed, and liver, muscle and adipose tissues are assessed for gene expression using targeted Illumina sequencing for selected genes. Based on reviewers comments during revision period, circulating n-3, n-6, n-9 and unsaturated fatty acids were assessed in the serum through collaboration with Jenifer I. Fenton and Travis Goeden, Michigan State University where samples were shipped for analysis of these lipids using mass spectrometry. These data were incorporated in the manuscript (Table 1) and part of figure 3. This dataset is associated with the following publication: Snow, S., A. Henriquez, W. Cheng, A. Fisher, B. Vallanat, M. Angrish, J. Richards, M.C. Schladweiler, C. Wood, H. Tong, and U. Kodavanti. Diets Enriched with Coconut, Fish, and Olive Oil Modify Peripheral Metabolic Effects of Ozone in Rats. TOXICOLOGY AND APPLIED PHARMACOLOGY. Academic Press Incorporated, Orlando, FL, USA, 410(1): 115337, (2020).

These data are published in a manuscript entitled Multi-tissue transcriptomic and serum metabolomic assessment reveals systemic implications of acute ozone-induced stress response in male Wistar Kyoto rats in the journal Metabolomics. This analyses explored systemic transcriptomic and circulating metabolomic effects of inhaled ozone exposure in rats. This dataset is associated with the following publication: Jackson, T., J. House, A. Henriquez, M. Schladweiler, K.M. Jackson, A. Astriab Fisher, S. Snow , D. Alewel, A. Motsinger-Reif, and U. Kodavanti. Multi-tissue transcriptomic and serum metabolomic assessment reveals systemic implications of acute ozone-induced stress response in male Wistar Kyoto rats. Metabolomics. Plenum Press, New York, NY, USA, 19: 81, (2023).

Physiologic data associated with different strains of common laboratory rat strains. This dataset is associated with the following publication: Gordon , C., P. Phillips , and A. Johnstone. Impact of Genetic Strain on Body Fat Loss, Food Consumption, Metabolism, Ventilation, and Motor Activity in Free Running Female Rats. PHYSIOLOGY AND BEHAVIOR. Elsevier Science Ltd, New York, NY, USA, 153: 56-63, (2016).

Raw data for all figures and tables in manuscript for study analyzing the impact of living conditions on cardiovascular function in ApoE -/- mice. This dataset is associated with the following publication: Fiamingo, M., S. Toler, K. Lee, W. Oshiro, Q. Krantz, P. Evansky, D. Davies, M. Gilmour, A. Farraj, and M. Hazari. Depleted housing elicits cardiopulmonary dysfunction after a single flaming eucalyptus wildfire smoke exposure in a sex-specific manner in ApoE knockout mice.. Cardiovascular Toxicology. Humana Press Incorporated, Totowa, NJ, USA, 24: 852-869, (2024).

Background Free radicals generated in biological systems by cigarette smoke (CS) inhalation can cause oxidative stress in tissues, resulting in lipid peroxidation (LPO). In view of the antioxidant properties of α-tocopherol (AT), in the present study, effects of AT on antioxidant defence system and LPO were investigated in mice inhaling CS for different time intervals. Results Male Balb/c mice were fed orally with AT (5 I.U./Kg.b.wt.) and /or exposed to CS for 2, 4, 6 or 8 weeks. No effect was observed on body growth, diet consumption, water intake and lung weight due to AT and /or CS treatment in any of the groups as compared to their control counterparts. After two weeks of treatment, no change in LPO, reduced glutathione (GSH) levels and antioxidant enzymes were observed except for glutathione reductase (GR) which increased in all the treated groups. A significant increase in pulmonary LPO levels was observed in mice exposed to CS inhalation for 4, 6 or 8 weeks. There was a gradual increase in the LPO levels as the extent of CS inhalation increased from 4 to 8 weeks. However, the extent of increase in LPO levels due to CS exposure for 4, 6 or 8 weeks in the mice treated with AT was comparatively less. A significant decrease in the GSH levels was also observed in all the animals exposed to CS for 4, 6 or 8 weeks. There was a significant increase in the activities of catalase, glutathione peroxidase (GSH-Px) and GR observed in all the groups exposed to CS for 4,6 or 8 weeks. The increase in above antioxidant enzymes seems to be insufficient to combat the oxidative stress posed by CS inhalation. There was a marked decrease observed in the LPO levels in the animals treated with AT alone for 4, 6, or 8 weeks, when compared to their control counterparts. However, the supplementation of AT for 4, 6 or 8 weeks demonstrated a significant increase in GSH levels. Conclusion It appears from our studies that AT exhibits its antioxidant role either directly by scavenging the oxidative species or indirectly by modulating the GSH levels.

고속도로 주변에 거주하는 사람들의 미세먼지 관련 질병인 호흡기질환, 심뇌혈관질환, 호흡기, 천식, 고혈압, 당뇨병 폐질환에 대한 시군구별 통계자료입니다. 미세먼지는 천식 환자에게 기침, 쌕쌕거림, 호흡곤란과 같은 천식 증상을 유발하고, 폐기능을 저하시킬 수 있으며, 심한 경우에는 천식 발작을 일으켜 응급실 방문이나 입원을 증가시킬 수 있습니다.본 자료는 미세먼지가 영향을 주는 질병에 대한 분석 및 오염물질과 질환자와의 상관관계 분석 등에 활용할 수 있습니다.

The dataset contains the results of a study examining the impact of vitamin D deficiency on the cardiopulmonary response of mice to photochemical smog. This dataset is associated with the following publication: Stratford, K., N. Coates, L. Thompson, T. Krantz, C. King, J. Krug, I. Gilmour, A. Farraj, and M. Hazari. Early-Life Persistent Vitamin D Deficiency Alters Cardiopulmonary Responses to Particulate Matter-Enhanced Atmospheric Smog in Adult Mice. ENVIRONMENTAL SCIENCE & TECHNOLOGY. American Chemical Society, Washington, DC, USA, 52(5): 3054-3061, (2018).