미국
AgAR (Agricultural Antibiotic Resistance)
,An Environmental Component of a "One Health" approach, the mission of the Agricultural Antibiotic Resistance (AgAR) project is to,ANTIBIOTIC DRUGS: Which drugs are the most relevant for each type of ag production system? At what level do excreted drugs continue to provide selective pressure in the environment?,RESISTANT BACTERIA: What is the relative contribution of specific bacteria to resistance in human clinical settings? Are some bacteria more likely than others to donate or receive resistance genes? What is the relative contribution of clonal spread of pathogens versus horizontal gene transfer?,RESISTANT GENES: How long do specific types of genes persist in agricultural samples? What conditions increase or decrease the likelihood of a successful transfer in manure, soil, water, and air? What is the role of the natural soil "resistome"?,AgAR Network Goals:,The AgAR network is composed of ARS scientists with an interest in understanding the ecology of antibiotic resistance in soil, water, air, insects, wildlife, and food. The network currently represents 4 national programs at 10 ARS locations across the United States, with over 200 peer-reviewed publications on AgAR topics, authored and co-authored by over 70 current and former ARS employees.,Activities:,Importance:,While there is broad agreement the use of antibiotics in food animals has the potential to adversely impact human clinical outcomes, the details of how this happens are unknown, and there is a critical need for information on antibiotic resistance (AR) in agricultural settings (AgAR). U.S. and international health organizations have taken the lead on identifying specific antibiotic drugs and resistant infections that are critical to human health. ARS is uniquely positioned to provide information on the "farm" side of the "farm to fork continuum". ARS scientists are able to address these questions in a practical way, by combining their experience (over 200 peer-reviewed ARS publications on antibiotic resistance) with their applied understanding of agricultural production systems.,ORGANIZATION: Scientists work on their own, individual research projects. The AgAR network provides resources to participants to encourage collaboration across program areas and geographical location.,MANAGEMENT: The AgAR network is operated using a wiki community approach. All participating scientists are encouraged to contribute to and share in the community resources. Currently, the group resources will be curated by the group coordinator, with input and guidance from a five person advisory panel.,RESOURCES: Bibliography of peer-reviewed AgAR papers by ARS authors • AgAR topic reference lists • information on meetings and conferences • "AR_in_environment" listserve • Community webinars,