The Distributed Structure-Searchable Toxicity (DSSTox) Database Network provides a public forum for search and publishing downloadable, structure-searchable, standardized chemical structure files associated with toxicity data.

The Distributed Structure Searchable Toxicity (DSSTox) online resource provides high quality chemical structures and annotations in association with toxicity data. It helps to build a data foundation for improved structure-activity relationships and predictive toxicology. DSSTox publishes summarized chemical activity representations for structure-activity modeling and provides a structure browser. This tool also houses the chemical inventories for the ToxCast and Tox21 projects.

The US Environmental Protection Agency’s (EPA) Distributed Structure-Searchable Toxicity (DSSTox) database, launched publicly in 2004, currently exceeds 875 K substances spanning hundreds of lists of interest to EPA and environmental researchers. From its inception, DSSTox has focused curation efforts on resolving chemical identifier errors and conflicts in the public domain towards the goal of assigning accurate chemical structures to data and lists of importance to the environmental research and regulatory community. In 2014, the legacy, manually curated DSSTox_V1 content was migrated to a MySQL data model, with modern cheminformatics tools supporting both manual and automated curation processes to increase efficiencies. Currently, DSSTox serves as the core foundation of EPA’s CompTox Chemicals Dashboard [https://comptox.epa.gov/dashboard], which provides public access to DSSTox content in support of a broad range of modeling and research activities within EPA and, increasingly, across the field of computational toxicology. This dataset is associated with the following publication: Grulke, C., A. Williams, I. Thillainadarajah, and A. Richard. EPA’s DSSTox database: History of development of a curated chemistry resource supporting computational toxicology research. Computational Toxicology. Elsevier B.V., Amsterdam, NETHERLANDS, 12: 100096, (2019).

The Human Exposure Database System (HEDS) provides public access to data sets, documents, and metadata from EPA on human exposure. It is primarily intended for scientists involved in human exposure studies or work requiring such data.

This tool is intended to aid individuals interested in learning more about chemicals that are manufactured or imported into the United States. Health and safety information on these chemicals, primarily in the form of paper documents, are routinely submitted by industry (manufacturers or importers of chemicals) to EPA under the Toxic Substances Control Act (TSCA). EPA is in the process of converting these documents into electronic form and making non-confidential versions of these documents accessible through this tool. The tool enables users to conduct both full text and metadata searches of these documents, and presents these as .pdf for viewing or downloading. The tool also queries existing EPA legacy database sources of chemical information and presents these data in a consistent format.

This tool is intended to aid individuals interested in learning more about chemicals that are manufactured or imported into the United States. Health and safety information on these chemicals, primarily in the form of paper documents, are routinely submitted by industry (manufacturers or importers of chemicals) to EPA under the Toxic Substances Control Act (TSCA). EPA is in the process of converting these documents into electronic form and making non-confidential versions of these documents accessible through this tool. The tool enables users to conduct both full text and metadata searches of these documents, and presents these as .pdf for viewing or downloading. The tool also queries existing EPA legacy database sources of chemical information and presents these data in a consistent format.

The Acute Exposure Guideline Levels Chemical Listing provides a complete listing of risk exposure guidelines from rare exposure to certain chemicals.

The Acute Exposure Guideline Levels Chemical Listing provides a complete listing of risk exposure guidelines from rare exposure to certain chemicals.