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Dataset from HDX-MS Studies of IgG1 Glycoforms and Their Interactions with the Fc(gamma)RIa (CD64) Receptor
This database gives hydrogen-deuterium exchange mass spectrometry (HDX-MS) data from measurements of three purified IgG1 glycoform samples, predominantly G0F, G2F, and SAF, in isolation and in complexation with the high-affinity receptor, Fc(gamma)RIa (CD64). The IgG1 antibody used in this study, aIL8hFc, is a murine-human chimeric IgG1, which inhibits IL-8 binding to human neutrophils. The working datasets comprise 17,750 deuterium uptake measurements in peptides from the receptor and the light and heavy chains of aIL8hFc obtained during 7 experiments, each comprising three runs of six exchange times. The data illuminate on the hydrogen exchange dynamics in isolated receptor, isolated IgG1 glycoforms, and receptor-IgG1 complexes.
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Glucocorticoid Ligand Mixtures Bioassay 3
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Raw data for each glucocorticoid ligand mixtures experiment. This dataset is associated with the following publication: MedlockKakaley, E., M. Cardon, E. Gray, P. Hartig, and V. Wilson. Generalized concentration addition model predicts glucocorticoid activity bioassay responses to environmentally detected receptor-ligand mixtures. TOXICOLOGICAL SCIENCES. Society of Toxicology, RESTON, VA, 252-263, (2019).
Glucocorticoid Ligand Mixtures Bioassay 1
공공데이터포털
Raw data for glucocorticoid receptor ligand exposure experiments. This dataset is associated with the following publication: MedlockKakaley, E., M. Cardon, E. Gray, P. Hartig, and V. Wilson. Generalized concentration addition model predicts glucocorticoid activity bioassay responses to environmentally detected receptor-ligand mixtures. TOXICOLOGICAL SCIENCES. Society of Toxicology, RESTON, VA, 252-263, (2019).
Glucocorticoid Ligand Mixtures Bioassay 2
공공데이터포털
Raw data for glucocorticoid receptor ligand exposure experiments. This dataset is associated with the following publication: MedlockKakaley, E., M. Cardon, E. Gray, P. Hartig, and V. Wilson. Generalized concentration addition model predicts glucocorticoid activity bioassay responses to environmentally detected receptor-ligand mixtures. TOXICOLOGICAL SCIENCES. Society of Toxicology, RESTON, VA, 252-263, (2019).
Untargeted MS-based Monitoring of Glucuronides in Fish
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Prioritization of environmental contaminants can be aided by detecting glucuronidated biotransformation products in fish using untargeted mass spectrometry-based metabolomics. This dataset is associated with the following publication: Evich, M., J. Mosley, I. Ntai, J. Cavallin, D. Villeneuve, G. Ankley, T. Collette, and D. Ekman. Untargeted MSn-Based Monitoring of Glucuronides in Fish: Screening Complex Mixtures for Contaminants with Biological Relevance.. ACS ES&T Water. American Chemical Society, Washington, DC, USA, 2(12): 2481–2490, (2022).
Compound 528847: Glycerol, 2,3-dimethyl, 1-tetradecanoate
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Chemical compound data from PubChem database. IUPAC Name: 2,3-dimethoxypropyl tetradecanoate. Molecular Formula: C19H38O4. Molecular Weight: 330.5. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.
Compound 528841: Glycerol, 2,3-dimethyl, 1-dodecanoate
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Chemical compound data from PubChem database. IUPAC Name: 2,3-dimethoxypropyl dodecanoate. Molecular Formula: C17H34O4. Molecular Weight: 302.4. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.
Compound 528848: Glycerol, 2,3-dimethyl,1-tridecanoate
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Chemical compound data from PubChem database. IUPAC Name: 2,3-dimethoxypropyl tridecanoate. Molecular Formula: C18H36O4. Molecular Weight: 316.5. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.
Compound 528833: Glycerol, 2,3-dimethyl, 1-(11-methyldodecanoate)
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Chemical compound data from PubChem database. IUPAC Name: 2,3-dimethoxypropyl 11-methyldodecanoate. Molecular Formula: C18H36O4. Molecular Weight: 316.5. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.
Compound 528839: Glycerol, 2,3-dimethyl, 1-(14-methylpentadecanoate)
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Chemical compound data from PubChem database. IUPAC Name: 2,3-dimethoxypropyl 14-methylpentadecanoate. Molecular Formula: C21H42O4. Molecular Weight: 358.6. This dataset contains comprehensive chemical information including structural data, physical properties, and biological activities. Useful for drug discovery, chemical research, and educational purposes.
Data submission for A-gf27
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Biomarker genes used to predict AhR activity; accession numbers of microarray datasets used in the study. This dataset is associated with the following publication: Oshida, K., N. Vasani, W. Ward , R. Thomas , D. Applegate, F. Gonzalez, L. Aleksunes, C. Klaassen, and C. Corton. Screening a mouse liver gene expression Compendium Identifies Effectors of the Aryl Hydrocarbon reeptors (AhR). TOXICOLOGICAL SCIENCES. Society of Toxicology, 336: 99-112, (2015).
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