RLWrankedLists.tar.gz:These lists linked to various chemical treatment conditions serve as the target collection of Cmap. Probes of the entire microarray are sorted based on their log fold changes over control conditions. RLWsignatures2015.tar.gz: These signatures linked to various chemical treatment conditions serve as queries in Cmap. This dataset is not publicly accessible because: too big in size. It can be accessed through the following means: located in the High Performance Computing archive /asm/FISHTOX/TAR_BALLs/fishCmap.tar.gz. Format: Fish connectivity mapping involves working with a large amount of data. Of primary interest to other researchers and general public are probably the rank-ordered gene lists and gene signatures. The former acts as a database-like target while the latter as queries. Along with fish Cmap outputs, they are contained in the file fishCmap.tar.gz as RLWrankedLists.tar.gz and RLWsignatures2015.tar.gz. This dataset is associated with the following publication: Wang , R., A. Biales , N. Garcia-Reyero, E. Perkins, D. Villeneuve, G. Ankley, and D. Bencic. Fish Connectivity Mapping: Linking Chemical Stressors by Their MOA-Driven Transcriptomic Profiles. BMC Genomics. BioMed Central Ltd, London, UK, 17(84): 1-20, (2016).

The maximum connectivity scores of pairwise chemical conditions summarized from Cmap results in a file with Cytoscape format (http://www.cytoscape.org/). The figures in the publication were generated from this file. The Cytoscape file is formed from importing the eight text file therein. This dataset is associated with the following publication: Wang , R., A. Biales , N. Garcia-Reyero, E. Perkins, D. Villeneuve, G. Ankley, and D. Bencic. Fish Connectivity Mapping: Linking Chemical Stressors by Their MOA-Driven Transcriptomic Profiles. BMC Genomics. BioMed Central Ltd, London, UK, 17(84): 1-20, (2016).

The maximum connectivity scores of pairwise chemical conditions summarized from Cmap results in a file with Cytoscape format (http://www.cytoscape.org/). The figures in the publication were generated from this file. The Cytoscape file is formed from importing the eight text file therein. This dataset is associated with the following publication: Wang , R., A. Biales , N. Garcia-Reyero, E. Perkins, D. Villeneuve, G. Ankley, and D. Bencic. Fish Connectivity Mapping: Linking Chemical Stressors by Their MOA-Driven Transcriptomic Profiles. BMC Genomics. BioMed Central Ltd, London, UK, 17(84): 1-20, (2016).

Various Cmap analyses within and across species and microarray platforms conducted and summarized to generate the tables in the publication. This dataset is associated with the following publication: Wang , R., A. Biales , N. Garcia-Reyero, E. Perkins, D. Villeneuve, G. Ankley, and D. Bencic. Fish Connectivity Mapping: Linking Chemical Stressors by Their MOA-Driven Transcriptomic Profiles. BMC Genomics. BioMed Central Ltd, London, UK, 17(84): 1-20, (2016).

Various Cmap analyses within and across species and microarray platforms conducted and summarized to generate the tables in the publication. This dataset is associated with the following publication: Wang , R., A. Biales , N. Garcia-Reyero, E. Perkins, D. Villeneuve, G. Ankley, and D. Bencic. Fish Connectivity Mapping: Linking Chemical Stressors by Their MOA-Driven Transcriptomic Profiles. BMC Genomics. BioMed Central Ltd, London, UK, 17(84): 1-20, (2016).

Data and code release to evaluate a continuous-flow streamside toxicity test that was conducted with common logperch (Percina caprodes) and larval sea lamprey (Petromyzon marinus) to evaluate the risk posed by 4-nitro-3-(trifluoromethyl)phenol (TFM) sea lamprey control stream treatments to logperch. Logperch are a host to the parasitic glochidia life stage of the federally endangered snuffbox mussel (Epioblasma triquetra). Streams with an extant population of snuffbox must be treated before May 1st to prevent inadvertent take through TFM-related mortality of glochidia-infested fish. The concentration of TFM required to induce 99.9% mortality of sea lamprey was 6.52 mg/L and the concentration of TFM required to induce 25% mortality of logperch was 10.14 mg/L. Our data show that logperch are not as sensitive as previously demonstrated and may result in the ability to treat streams after the current May 1st restriction. Any use of trade, firm, or product names is for descriptive purposes only and does not imply endorsement by the U.S. Government.

Results of partial least squares (PLS) analysis of metabolite changes and contaminant concentrations to determine contaminants most likely to responsible for biological effects and to screen against those contaminants not responsible. This dataset is associated with the following publication: Ekman, D., K. Keteles, J. Beihoffer, J. Cavallin, K. Dahlin, J. Davis, A. Jastrow, J. Lazorchak, M. Mills, M. Murphy, D. Nguyen, A. Vajda, D. Villeneuve, D. Winkelman, and T. Collette. Evaluation of targeted and untargeted effects-based monitoring tools to assess impacts of contaminants of emerging concern on fish in the South Platte River, CO. ENVIRONMENTAL POLLUTION. Elsevier Science Ltd, New York, NY, USA, 239: 706-713, (2018).