This study sought to examine whether mild preexisting allergic airways disease enhances the response of the lungs to burn pit smoke emissions. The findings indicate that exposure to house dust mite (HDM) antigen sensitizes the mouse lungs to make them more susceptible to burn pit smoke-induced dysfunction, in both the inflammatory response to burn pit smoke and in the accumulation of airway mucus. This suggests that changes in cilia and mucociliary clearance (MCC) induced by asthma that are amplified by inhalation of burn pit smoke, followed by a feedback loop of enhanced inflammation induced by the accumulating mucus, appears a likely mechanism. This dataset is associated with the following publication: Belfield-Simpson, L., J. Martin, M.K. McPeek, A. Livraghi-Butrico, H. Dang, Y.H. Kim, I. Gilmour, and C. Doerschuk. Combustion products of burn pit constituents induce more changes in asthmatic than non-asthmatic murine lungs. Particle and Fibre Toxicology. BioMed Central Ltd, London, UK, 22: 21, (2025).

A manuscript describing the independent roles of beta adrenergic and glucocorticoid receptors in mediating ozone-induced pulmonary and systemic effects. This dataset is associated with the following publication: Henriquez, A., S. Snow, M.C. Schladweiler, C. Miller, and U. Kodavanti. Independent roles of beta-adrenergic and glucocorticoid receptors in systemic and pulmonary effects of ozone. INHALATION TOXICOLOGY. Taylor & Francis, Inc., Philadelphia, PA, USA, 32(4): 155-169, (2020).

A manuscript describing the independent roles of beta adrenergic and glucocorticoid receptors in mediating ozone-induced pulmonary and systemic effects. This dataset is associated with the following publication: Henriquez, A., S. Snow, M.C. Schladweiler, C. Miller, and U. Kodavanti. Independent roles of beta-adrenergic and glucocorticoid receptors in systemic and pulmonary effects of ozone. INHALATION TOXICOLOGY. Taylor & Francis, Inc., Philadelphia, PA, USA, 32(4): 155-169, (2020).

Background: Recent investigations have shown that leukocyte activation is involved in the pathogenesis of ventilator-associated lung injury. This study was designed to investigate whether the inflammatory responses and deterioration of oxygenation in ventilator-associated lung injury are attenuated by high-frequency oscillatory ventilation (HFO). We analyzed the effects of HFO compared with conventional mechanical ventilation (CMV) on the activation of pulmonary macrophages and neutrophils in 10 female rabbits. Results: After surfactant depletion, the rabbits were ventilated by CMV or HFO at the same mean airway pressure. Surfactant-depletion followed by 4 h mechanical ventilation hindered pulmonary oxygenation in both groups. Impairment of oxygenation was less severe in the HFO group than in the CMV group. In the HFO group the infiltration of granulocytes into alveolar spaces occurred more readily than in the CMV group. Compared with CMV, HFO resulted in greater attenuation of β2-integrin expression, not only on granulocytes, but also on macrophages. Conclusions: In the surfactant-depleted lung, the activation of leukocytes was attenuated by HFO. Reduced inflammatory response correlated with decreased impairment of oxygenation. HFO may reduce lung injury via the attenuation of pulmonary inflammation.

Evidence for a role of diet in asthma and chronic obstructive pulmonary disease (COPD) has been accumulating rapidly over the past decade. Associations have been reported between the intake of fruit, fish, antioxidant vitamins, fatty acids, sodium or magnesium, and indicators of asthma and COPD. Several issues need to be addressed before causality of these associations can be established. The role of diet in the development of disease and the induction time and reversibility of the effect needs further investigation. The role of smoking habits in the relation of diet and respiratory disease also needs to be elucidated. Nevertheless, based on the available evidence, dietary guidelines could be proposed for the primary and secondary prevention of asthma and COPD that are in line with existing dietary guidelines for the prevention of coronary heart disease and cancer.

Data collected during the comparison of ozone responsiveness in primary bronchial epithelial cells from a range of distinct donors. This dataset is associated with the following publication: Bowers, E., S. McCullough, D. Morgan, L. Dailey, and D. Diaz-Sanchez. ERK1/2 and p38 regulate inter-individual variability in ozone-mediated IL-8 gene expression in primary human bronchial epithelial cells. Scientific Reports. Nature Publishing Group, London, UK, 8(1): 9398, (2018).

Data collected during the comparison of ozone responsiveness in primary bronchial epithelial cells from a range of distinct donors. This dataset is associated with the following publication: Bowers, E., S. McCullough, D. Morgan, L. Dailey, and D. Diaz-Sanchez. ERK1/2 and p38 regulate inter-individual variability in ozone-mediated IL-8 gene expression in primary human bronchial epithelial cells. Scientific Reports. Nature Publishing Group, London, UK, 8(1): 9398, (2018).