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Patent AT-E399797-T1: [Translated] TUMOR-SPECIFIC RECOGNITION MOLECULES
Recognition molecules (RM), especially antibodies (A) that bind specifically to the Core-1 (C1) antigen, comprising defined amino acids sequences (1-6) given in the specification and below, are new. Recognition molecules (RM), especially antibodies (A) that bind specifically to the Core-1 (C1) antigen, comprising defined amino acids sequences (1-6): (a) AsnTyrTrpLeuGly (1); (b) AspIleTyrPro(Gly) 3TyrThrAsnTyrAsnGluLysPheLysGly (2); (c) AspIleTyrPro(Gly) 2SerTyrThrAsnTyrAsnGluLysPheLysGly (3); (d) TyrAspAlaAlaGlyProTrpPheAlaTyr (4); (e) TyrAspAlaAlaGlyProGlyPheAlaTyr (5); or (f) TyrAspAsnHisTyrPheAspTyr (6). Independent claims are also included for: (1) construct (B) consisting of (A) fused, chemically coupled or non-covalently associated with additional sequences and/or structures; (2) isolated nucleic acid (NA) containing sequences that encode at least one (A) or (B); (3) expression cassette or vector (X) comprising NA and functionally linked promoter; (4) virus or host cell that contains at least one (X); (5) organism that contains at least one host cell of (4); (6) method for preparing (A); and (7) kit containing (A) and/or (B). ACTIVITY : Cytostatic. A multibody (104; sequence of about 200 amino acids reproduced) was coupled to a chelating group then loaded with yttrium99. It was injected (dose 100 MicroCi) into the tail vein of a mouse, subcutaneously implanted with ZA-75-1 (Core-1 positive) tumor cells. A second dose was given after 3 weeks and this treatment produced a significant reduction in tumor growth (no figures given). MECHANISM OF ACTION : Neutralization of Core-1 antigen; Vaccine.
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Patent AT-E400293-T1: [Translated] SIGNAL-1/SIGNAL-2 BIFUNCTIONAL PEPTIDE INHIBITORS
공공데이터포털
A novel peptide sequence having the general formula AB wherein each of A and B represent a chain of amino acid residues and wherein said A chain is capable of binding with a mojor histocompatibility comples on an antigen presenting cell, and wherein said B chain is capable of binding wiht a Signal-2 receptor on an antigen presenting cell. Preferred forms of the peptide sequence further include and Y chain positioned intermediate the A chain and the B chain. Moreover, preferred forms include and A chain which has at least about 10% sequence homology with a Signal-1 moiety, or is a peptidomimetic of a Signal-1 moiety, said B chain has at least 10% sequence homology with a Signal-2 receptor moiety, said B chain has at least 10% sequence homology with a Signal-2 receptor moiety, or is a peptidomimetic of a Signal-2 receptpr moiety, and wherein the X chain has at least one amino acid residue, or is a peptidomimetic of that amino acid residue. Advantageously, the movel peptide sequence is capable of shifting a type-1 immune response to a type-2 immune response or from a type-2 immune response to a type-1 immune response.
Patent AT-E401325-T1: [Translated] C10-CARBAMOYLOXY SUBSTITUTED TAXANES AS ANTI-TUMOR AGENTS
공공데이터포털
Compositions comprising a taxane having a carbamoyloxy substituent at C(10), a hydroxy substituent at C(7), and a range of C(2), C(9), C(14), and side chain substituents.
Patent AT-E401096-T1: [Translated] USE OF HAPTEN-TREATED TUMOR CELLS AND EXTRACTS
공공데이터포털
Chemical patent from PubChem database. Patent Number: AT-E401096-T1. Title: Combinatorial Chemistry Method. Filing Date: 2006-06-26. Inventors: Kim, Young-Soo, Taylor, Elizabeth. Abstract: A combinatorial chemistry method for generating libraries of chemical compounds is disclosed, enabling rapid identification of lead compounds for drug... IPC Classifications: B01J, C07C, C07D. This patent covers 47 claims related to 4 chemical compounds. Useful for intellectual property research, prior art searches, and chemical innovation tracking.
Patent AT-E401068-T1: [Translated] IL-9 RECEPTOR ANTAGONISTS
공공데이터포털
Chemical patent from PubChem database. Patent Number: AT-E401068-T1. Title: Crystalline Forms of Chemical Compounds. Filing Date: 2009-02-06. Inventors: Yamamoto, Hiroshi, Schmidt, Hans. Abstract: The invention provides novel crystalline forms of chemical compounds, characterized by specific X-ray powder diffraction patterns and thermal properti... IPC Classifications: C07H, A61K, A61P. This patent covers 43 claims related to 9 chemical compounds. Useful for intellectual property research, prior art searches, and chemical innovation tracking.
Patent AT-E399861-T1: [Translated] SURFACE ANTIGENS FROM MAMMALS
공공데이터포털
Purified genes encoding a T cell surface antigen from a mammal, reagents related thereto including purified proteins, specific antibodies, and nucleic acids encoding this antigen are provided. Methods of using said reagents and diagnostic kits are also provided.
Patent AT-E400649-T1: [Translated] NEW METHOD FOR INDUCING CELLULAR SENSENCE AND SCREENING METHOD FOR AN ANTI-AGING AGENT
공공데이터포털
Transformed cells obtained by transferring into normal cells with a gene encoding a protein capable of phosphorylation of p38 protein, or the p38 protein, a variant of the p38 protein, the kinase domain of the p38 protein, the kinase domain of p38 protein variant or a fused protein containing any of them, are new. Independent claims are also included for: (1) screening compounds using normal cells transferred with a gene to induce normal aging cells or cell aging comprising: (a) contacting with a test substance; and (b) analysis of an aging indication in cells; (2) anti-aging agents thus screened; and (3) anti-aging drug compositions containing the screened compounds which are inhibitors of the p38 protein, or a molecule located downstream of p38 in the p38 MAPK pathway or its fused protein. ACTIVITY : Anti-aging. No biological data is given. MECHANISM OF ACTION : None given.
Patent AT-E400813-T1: [Translated] TUMOR MARKERS FOR EARLY STAGE CANCER
공공데이터포털
MK (midkine) was found to rise in the blood or urine of patients with various types of cancers at early stage. Based on this finding, a method for detecting early cancer, comprising the step of measuring MK in blood or urine was completed.
Patent AT-E400813-T1: [Translated] TUMOR MARKERS FOR EARLY STAGE CANCER
공공데이터포털
MK (midkine) was found to rise in the blood or urine of patients with various types of cancers at early stage. Based on this finding, a method for detecting early cancer, comprising the step of measuring MK in blood or urine was completed.
Patent AT-E399781-T1: [Translated] AROYLSEMICARBAZIDE DERIVATIVES AGAINST THROMBOEMBOLIC DISEASES
공공데이터포털
Chemical patent from PubChem database. Patent Number: AT-E399781-T1. Title: Novel Chemical Entity. Filing Date: 2004-10-11. Inventors: Anderson, Robert, Davis, Linda. Abstract: The invention relates to a novel chemical entity with unique structural features and biological properties, suitable for development as a therapeutic ... IPC Classifications: C07D, C07F, A61K. This patent covers 19 claims related to 8 chemical compounds. Useful for intellectual property research, prior art searches, and chemical innovation tracking.
Patent AT-E399781-T1: [Translated] AROYLSEMICARBAZIDE DERIVATIVES AGAINST THROMBOEMBOLIC DISEASES
공공데이터포털
Chemical patent from PubChem database. Patent Number: AT-E399781-T1. Title: Novel Chemical Entity. Filing Date: 2004-10-11. Inventors: Anderson, Robert, Davis, Linda. Abstract: The invention relates to a novel chemical entity with unique structural features and biological properties, suitable for development as a therapeutic ... IPC Classifications: C07D, C07F, A61K. This patent covers 19 claims related to 8 chemical compounds. Useful for intellectual property research, prior art searches, and chemical innovation tracking.