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PCB Noncancer Effects Evidence Map
Supporting data for the peer reviewed manuscript "A systematic evidence map for the evaluation of noncancer health effects and exposures to polychlorinated biphenyl mixtures" and the accompanying government report "A Systematic Evidence Map of Noncancer Health Endpoints and Exposures to Polychlorinated Biphenyl (PCB) Mixtures". This dataset is associated with the following publications: Carlson, L., K. Christensen, S. Sagiv, P. Rajan, C. Klocke, P. Lein, E. Coffman, R. Shaffer, E. Yost, X. Arzuaga Andino, P. Factor-Litvak, A. Sergeev, M. Toborek, M. Bloom, J. Trgovcich, T. Jusko, L. Robertson, J. Meeker, A. Keating, R. Blain, R. Silva, S. Snow, C. Lin, K. Shipkowski, B. Ingle, and G. Lehmann. A Systematic Evidence Map for The Evaluation of Noncancer Health Effects and Exposures to Polychlorinated Biphenyl Mixtures. ENVIRONMENTAL RESEARCH. Elsevier B.V., Amsterdam, NETHERLANDS, 220: 115148, (2023). Carlson, L., G. Lehmann, E. Yost, B. Ingle, E. Coffman, K. Christensen, R. Shaffer, J. Trgovcich, S. Sagiv, P. Rajan, C. Klocke, P. Lein, A. Sergeev, M. Bloom, M. Toborek, L. Robertson, T. Jusko, J. Meeker, A. Keating, C. Lin, K. Shipkowski, and R. Silva. Systematic Evidence of Noncancer Health Effects of PCB Mixtures. U.S. Environmental Protection Agency, Washington, DC, USA, 2023.
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Polychlorinated Biphenyls (PCB) Residue Effects Database
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The PCB Residue Effects (PCBRes) Database was developed to assist scientists and risk assessors in correlating PCB and dioxin-like compound residues with toxic effects. The purpose is to develop PCB critical residue values for fish, mammals and birds, especially as these relate to aquatic and aquatic-dependent species.
Polychlorinated Biphenyls (PCB) Residue Effects Database
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The PCB Residue Effects (PCBRes) Database was developed to assist scientists and risk assessors in correlating PCB and dioxin-like compound residues with toxic effects. The purpose is to develop PCB critical residue values for fish, mammals and birds, especially as these relate to aquatic and aquatic-dependent species.
Polychlorinated Biphenyls Mixtures Similarity Tool (MiST)
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The PCB Mixtures Similarity Tool (MiST) is an Excel-based tool that automates the process for determining whether two PCB mixtures are "sufficiently similar". Humans are exposed to complex mixtures of PCBs in the environment; however, only a small subset of PCB mixtures has been tested for toxicity. MiST was developed as a tool for risk assessors to evaluate how dose-response information for tested PCB mixtures may serve as a surrogate when assessing untested mixtures found in the environment.
Evaluation of polycyclic aromatic hydrocarbons in fine particulate matter censoring-related bias.csv
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The case study data are selected from an EPA study using cookstove combustion experiments to measure polycyclic aromatic hydrocarbon (PAH) concentrations in particulate matter (PM) and were determined using gas chromatography-mass spectrometry (GC-MS) (Shen et al. 2017). Chromatograms of particle emissions reported in Shen et al. (2017) were reanalyzed for the case study to quantify previously censored measurements where the signal-to-noise ratio was >1. This dataset is associated with the following publication: George, B., L. Gains-Germain, K. Broms, K. Black, M. Furman, M. Hays, K. Thomas, and J.E. Simmons. Censoring Trace-Level Environmental Data: Statistical Analysis Considerations to Limit Bias. ENVIRONMENTAL SCIENCE & TECHNOLOGY. American Chemical Society, Washington, DC, USA, 55(6): 3786-3795, (2021).
Expanded ORD PFAS SEM
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We used systematic evidence map methods to summarize the available epidemiological and animal bioassay evidence for an expanded set of ~345 PFAS that were prioritized in 2019 by the EPA’s Center for Computational Toxicology and Exposure (CCTE) for in vitro toxicity and toxicokinetic screening. This work builds upon our previously published evidence map for ~150 PFAS chemicals (Carlson et al. 2022, https://doi.org/10.1289/EHP10343). This dataset is associated with the following publication: Shirke, A., E. Radke-Farabaugh, C. Lin, R. Blain, N. Vetter, c. lemeris, p. hartman, H. Hubbard, M. Angrish, X. Arzuaga Andino, J. Congleton, J. Davis, L. Dishaw, R. Jones, R. Judson, J. Kaiser, A. Kraft, L. Lizarraga, P. Noyes, G. Patlewicz, M. Taylor, A. Williams, K. Chialton, and L. Carlson. Expanded Systematic Evidence Map for Hundreds of Per- and Polyfluoroalkyl Substances (PFAS) and Comprehensive PFAS Human Health Dashboard. ENVIRONMENTAL HEALTH PERSPECTIVES. National Institute of Environmental Health Sciences (NIEHS), Research Triangle Park, NC, USA, 132(2): CID: 026001, (2024).
PBPK modeloutputs readme
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Contains values from pbpk models for each study on n-butanol effects. This dataset is associated with the following publication: Segal, D., A. Bale, L. Phillips, A. Sasso, P. Schlosser, C. Starkey, and S. Makris. Issues in Assessing the Health Risks of n-Butanol. JOURNAL OF APPLIED TOXICOLOGY. John Wiley & Sons, Ltd., Indianapolis, IN, USA, 40(1): 72-86, (2020).
Multipollutant health effect simulations
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Resulting betas (health effects) from a variety of copollutant epidemiologic models used to analyze the impact of exposure measurement error on health effect estimates. This dataset is associated with the following publication: Dionisio , K., H.H. Chang, and L. Baxter. A simulation study to quantify the impacts of exposure measurement error on air pollution health risk estimates in copollutant time-series models.. ENVIRONMENTAL HEALTH. Academic Press Incorporated, Orlando, FL, USA, 15: 114, (2016).
Dataset of Chemosphere Publication in 2015, Chamber study of PCB emissions from caulking materials and light ballasts
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The data presented in this data file is a product of a journal publication. The dataset contains PCB chamber air concentrations emitted from caulk and model simulation of PCB air concentrations in a room with a PCB caulk. This dataset is associated with the following publication: Liu , X., Z. Guo, K. Krebs , R. Stinson, J. Nardin, R. Pope, and N. Roache. Chamber study of polychlorinated biphenyl (PCB)emissions from caulking materials and light ballasts. ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH. Ecomed Verlagsgesellschaft AG, Landsberg, GERMANY, 137: 115-121, (2015).
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