Data relative to the paper entitled " Ozone-induced fetal growth restriction in rats is associated with sexually dimorphic placental and fetal metabolic adaptation.". This dataset is associated with the following publication: Miller, C., J. Dye, A. Henriquez, E. Stewart, K. Lavrich, G. Carswell, H. Ren, D. Freeborn, S. Snow, M.C. Schladweiler, J. Richards, P.R. Kodavanti, A. Fisher, B. Chorley, and U. Kodavanti. Ozone-induced fetal growth restriction in rats is associated with sexually dimorphic placental and fetal metabolic adaptation.. Molecular Metabolism. Elsevier B.V., Amsterdam, NETHERLANDS, 20(42): 101094, (2020).

Data from Prenatal ozone exposure programs a sexually dimorphic susceptibility to high fat diet in adolescent Long-Evans rats. This dataset is associated with the following publication: Stewart, E., J. Dye, M. Schladweiler, P. Phillips, K. McDaniel, J. Richards, R. Grindstaff, W. Padgett, M. Moore, D. Jenkins-Hill, C. Gordon, U. Kodavanti, and C. Miller. Prenatal ozone exposure programs a sexually dimorphic susceptibility to high fat diet in adolescent Long-Evans rats.. FASEB JOURNAL. Federation of American Societies for Experimental Biology (FASEB), Bethesda, MD, USA, 36(12): e22664, (2022).

Data related to the effects of peri-implantation ozone exposure on maternal and fetal health outcomes at the end of gestation. This dataset is associated with the following publication: Miller, C., J. Dye, A. Ledbetter, M. Schladweiler, J. Richards, S. Snow, C. Wood, A. Henriquez, L. Thompson, A. Farraj, M. Hazari, and U. Kodavanti. Uterine Artery Flow and Offspring Growth in Long-Evans Rats following Maternal Exposure to Ozone during Implantation. ENVIRONMENTAL HEALTH PERSPECTIVES. National Institute of Environmental Health Sciences (NIEHS), Research Triangle Park, NC, USA, 125(12): 127005, (2017).

Data related to the effects of peri-implantation ozone exposure on maternal and fetal health outcomes at the end of gestation. This dataset is associated with the following publication: Miller, C., J. Dye, A. Ledbetter, M. Schladweiler, J. Richards, S. Snow, C. Wood, A. Henriquez, L. Thompson, A. Farraj, M. Hazari, and U. Kodavanti. Uterine Artery Flow and Offspring Growth in Long-Evans Rats following Maternal Exposure to Ozone during Implantation. ENVIRONMENTAL HEALTH PERSPECTIVES. National Institute of Environmental Health Sciences (NIEHS), Research Triangle Park, NC, USA, 125(12): 127005, (2017).

Maternal high-fat diet (HFD) and obesity can increase the susceptibility of offspring to inhaled pollutants. In this study, we examined the influence of maternal HFD on metabolic responses to ozone in young Long-Evans rat offspring. F0-females began control (CD; 10%kcal from fat) or high-fat diet (HFD; 60%kcal from fat) at post-natal day (PND)-30. Rats were bred on PND-72 and allowed to give birth. Dietary regimen was maintained until PND-30 and then all offspring were switched to CD. On PND-40, female and male offspring-F1 (n=10/group) were exposed to air or 0.8-ppm ozone for 5h and within 1h serum samples were collected for neuroendocrine hormones and global metabolomic analysis. Offspring from HFD-dams had increased body fat and weight relative to CD, however, no major changes in circulating hormones were noted. Metabolomic analysis revealed significant sex, diet, and exposure-related changes in metabolites. Maternal HFD increased free fatty acids and decreased phospholipids (female>male). Also, microbiome-associated histidine and tyrosine metabolites were increased in both sexes of offspring, while 1,5-anhydroglucitol levels decreased in males. Ozone exposure increased free fatty acids in males from CD-dams but decreased in females from HFD-dams. Ozone also decreased monohydroxy fatty acids and acyl carnitines in females (HFD>CD). Moreover, it increased pyruvate along with TCA cycle intermediates in females suggesting an increase in glucose utilization. Ozone increased various amino acids, polyamines and metabolites of gut microbiota in HFD female offspring. Collectively, these data suggest that maternal HFD increases offspring susceptibility to metabolic alterations in a sex-specific manner when challenged with environmental stressors. This dataset is associated with the following publication: Snow, S., K. Broniowska, E. Karoly, A. Henriquez, P. Phillips, A. Ledbetter, M. Schladweiler, C. Miller, C. Gordon, and U. Kodavanti. Offspring Susceptibility to Metabolic Alterations Due to Maternal High Fat Diet and the Impact of Inhaled Ozone Used as a Stressor. Scientific Reports. Nature Publishing Group, London, UK, 1, (2020).

Maternal high-fat diet (HFD) and obesity can increase the susceptibility of offspring to inhaled pollutants. In this study, we examined the influence of maternal HFD on metabolic responses to ozone in young Long-Evans rat offspring. F0-females began control (CD; 10%kcal from fat) or high-fat diet (HFD; 60%kcal from fat) at post-natal day (PND)-30. Rats were bred on PND-72 and allowed to give birth. Dietary regimen was maintained until PND-30 and then all offspring were switched to CD. On PND-40, female and male offspring-F1 (n=10/group) were exposed to air or 0.8-ppm ozone for 5h and within 1h serum samples were collected for neuroendocrine hormones and global metabolomic analysis. Offspring from HFD-dams had increased body fat and weight relative to CD, however, no major changes in circulating hormones were noted. Metabolomic analysis revealed significant sex, diet, and exposure-related changes in metabolites. Maternal HFD increased free fatty acids and decreased phospholipids (female>male). Also, microbiome-associated histidine and tyrosine metabolites were increased in both sexes of offspring, while 1,5-anhydroglucitol levels decreased in males. Ozone exposure increased free fatty acids in males from CD-dams but decreased in females from HFD-dams. Ozone also decreased monohydroxy fatty acids and acyl carnitines in females (HFD>CD). Moreover, it increased pyruvate along with TCA cycle intermediates in females suggesting an increase in glucose utilization. Ozone increased various amino acids, polyamines and metabolites of gut microbiota in HFD female offspring. Collectively, these data suggest that maternal HFD increases offspring susceptibility to metabolic alterations in a sex-specific manner when challenged with environmental stressors. This dataset is associated with the following publication: Snow, S., K. Broniowska, E. Karoly, A. Henriquez, P. Phillips, A. Ledbetter, M. Schladweiler, C. Miller, C. Gordon, and U. Kodavanti. Offspring Susceptibility to Metabolic Alterations Due to Maternal High Fat Diet and the Impact of Inhaled Ozone Used as a Stressor. Scientific Reports. Nature Publishing Group, London, UK, 1, (2020).

This data set for this manuscript is contained within one Excel file.The different tabs of the spreadsheet pertain to each figure found in the manuscript. This file was finalized on 2/1/19 to reflect any changes made to the figures in response to reviewers comments following submission to JTEH. This dataset is associated with the following publication: Snow, S., K. Broniowska, E. Karoly, A. Henriquez, P. Phillips, A. Ledbetter, A. Johnstone, M. Schladweiler, C. Gordon, and U. Kodavanti. Offspring susceptibility to metabolic alterations due to maternal high-fat diet and the impact of inhaled ozone used as a stressor#. Scientific Reports. Nature Publishing Group, London, UK, 10(1): 16353, (2020).

Ozone Exposure During Implantation Increases Serum Bioactivity in HTR-8/SVneo Trophoblasts data. This dataset is associated with the following publication: Miller, C., E. Stewart, S. Snow, W. Williams, J. Richards, L. Thompson, M. Schladweiler, A. Farraj, U. Kodavanti, and J. Dye. Ozone exposure during implantation increases serum bioactivity in HTR8/SVneo trophoblasts. TOXICOLOGICAL SCIENCES. Society of Toxicology, RESTON, VA, 168(2): 535-550, (2019).

Ozone Exposure During Implantation Increases Serum Bioactivity in HTR-8/SVneo Trophoblasts data. This dataset is associated with the following publication: Miller, C., E. Stewart, S. Snow, W. Williams, J. Richards, L. Thompson, M. Schladweiler, A. Farraj, U. Kodavanti, and J. Dye. Ozone exposure during implantation increases serum bioactivity in HTR8/SVneo trophoblasts. TOXICOLOGICAL SCIENCES. Society of Toxicology, RESTON, VA, 168(2): 535-550, (2019).

This dataset provides key data files and scripts used in the analysis for the published manuscript "Changes in ozone chemical sensitivity in the U.S. from 2007 to 2016" ; https://pubs.acs.org/doi/abs/10.1021/acsenvironau.1c00029. Citation information for this dataset can be found in the EDG's Metadata Reference Information section and Data.gov's References section.