RAW DATA, SAS FILES AND DATA MEANS. This dataset is associated with the following publication: Howdeshell, K., C. Rider, V. Wilson , J. Furr , C. Lambright , and E. Gray. Dose addition models based on biologically-relevant reductions in fetal testosterone accurately predict postnatal reproductive tract alterations by a phthalate mixture in rats. TOXICOLOGICAL SCIENCES. Society of Toxicology, 148(2): 488-502, (2015).

effects of in utero phthalate and other chemical administration on male rat sexual differentiation: Non PPAR mediated AOP. This dataset is associated with the following publication: Gray, E., J. Conley, C. Lambright, N. Evans, J. Furr, V. Wilson, B. Hannas, P. Foster, and H. Sampson. Genomic and Hormonal Biomarkers of Phthalate-induced Male Rat Reproductive Developmental Toxicity: Part II A Targeted RT-qPCR Array Approach that Defines a Unique Adverse Outcome Pathway.. TOXICOLOGICAL SCIENCES. Society of Toxicology, RESTON, VA, 182(2): 195-214, (2021).

Background Saliva reflects the plasma free fraction of testosterone which is biologically active, and available for uptake by tissues. Testosterone concentration in saliva, though differing slightly from the concentration of unbound testosterone in serum, is in good correlation with the latter, indicating that salivary testosterone provides a reliable method for determination of serum free testosterone. The study aimed to investigate salivary testosterone levels and their changes in preadolescent children and to study sexual dimorphism. Methods Testosterone levels were determined in 203 healthy preadolescent children (77 girls and 126 boys) from saliva samples by radioimmunoassay. Sampling was performed once a year with respect to circadian and seasonal fluctuations of testosterone. Data were statistically analyzed by Statgraphic software. Results Mean salivary testosterone concentrations (± SD) were 0.038 ± 0.012 nmol/L and 0.046 ± 0.026 nmol/L for girls and boys, with the medians 0.035 nmol/L and 0.041 nmol/L, respectively. Statistical analysis did not prove changes in salivary testosterone concentrations in the preadolescent period of life, with an exception of the insignificant fall at the age of 7 years, and an insignificant rise at the age of 9 years in girls. Conclusions Generally it can be concluded that salivary testosterone levels in our prepubertal subjects remained stable. There was no significant increase of salivary testosterone levels from the age of 6 until the age of 9 in both sexes. Sexual dimorphism in salivary testosterone levels was proved with significantly higher (p = 0.009) salivary testosterone levels in boys than in girls.

Dataset includes summary data for all endpoints measured in the experiments reported in the manuscript. This dataset is associated with the following publication: GUPTA, M., J. Conley, C. Lambright, L. Chin, S. HILL, L. Gray, and D. SPADE. Dose-response assessment of dipentyl phthalate effects on testosterone production and morphogenesis of late-gestation fetal rat testis. ENVIRONMENT INTERNATIONAL. Elsevier B.V., Amsterdam, NETHERLANDS, 200: 109551, (2025).

GEOSite dataset for article 'In vitro transcriptomic analyses reveal pathway perturbations, estrogenic activities, and potencies of data-poor BPA alternative chemicals '. This dataset is associated with the following publication: Matteo, G., K. Leingartner, A. Rowan-Carroll, M. Meier, A. Williams, M. Beal, M. Gagne, R. Farmahin, S. Wickramasuriya, A.J. Reardon, T. Barton-Maclaren, J. Corton, C. Yauk, and E. Atlas. In vitro transcriptomic analyses reveal pathway perturbations, estrogenic activities, and potencies of data-poor BPA alternative chemicals. TOXICOLOGICAL SCIENCES. Society of Toxicology, RESTON, VA, 191(2): 266-275, (2023).

data set has a description of the information in the excell file and all the data used in the study. This dataset is associated with the following publication: Gray, E., J. Conley, C. Lambright, and J. Furr. In utero exposure to a mixture of the perfluoroalkylisopropyl pesticide pyrifluquinazon with dibutyl phthalate cumulatively disrupts male rat reproductive development via different mechanisms of action. TOXICOLOGICAL SCIENCES. Society of Toxicology, RESTON, VA, 188(2): 234-247, (2022).

dicyclohexyl phthalate fetal testis data

The greater dynamic range of testosterone production in a highly purified rat Leydig cell assay permitted the detection of chemical induced inhibition that was not detected by the high throughput screening format of the H295R steroidogenesis assay. This dataset is associated with the following publication: Klinefelter , G., J. Laskey, and R. Amann. Statin Drugs Markedly Inhibit Testosterone Production by Rat Leydig Cells In Vitro: Implications for Men. REPRODUCTIVE TOXICOLOGY. Elsevier Science Ltd, New York, NY, USA, 45: 52-58, (2014). NOTE: This dataset has been removed from public access due to revocation. Please refer inquiries regarding this dataset to the listed contact person.

Dataset includes all endpoint measurements from studies described in the manuscript and SAS code for statistical analyses of data. This dataset is associated with the following publication: Gray, L., C. Lambright, N. Evans, J. Ford, and J. Conley. Comparison of in utero phthalate exposure on fetal rat testis transcript and endocrine alterations with apical reproductive alterations in male rats. TOXICOLOGY AND APPLIED PHARMACOLOGY. Elsevier B.V., Amsterdam, NETHERLANDS, 502: 117447, (2025).

All summary data associated with manuscript figures and tables. This dataset is associated with the following publication: Conley, J., C. Lambright, N. Evans, M. Cardon, E. MedlockKakaley, V. Wilson, and E. Gray. A mixture of 15 phthalates and pesticides below individual chemical No Observed Adverse Effect Levels (NOAELs) produces reproductive tract malformations in the male rat. ENVIRONMENT INTERNATIONAL. Elsevier B.V., Amsterdam, NETHERLANDS, 156(106615): 1, (2021).