Maternal and fetal liver gene expression and pathway changes following exposure to perfluorooctanoic acid (PFOA) or hexafluoropropylene oxide-dimer acid (HFPO-DA) during gestation. This dataset is associated with the following publication: Blake, B., C. Miller, H. Nguyen, V. Chappell, T. Phan, D. Phadke, M. Balik-Meisner, D. Mav, R. Shah, and S. Fenton. Transcriptional pathways linked to fetal and maternal hepatic dysfunction caused by gestational exposure to perfluorooctanoic acid (PFOA) or hexafluoropropylene oxide-dimer acid (HFPO-DA or GenX) in CD-1 mice. ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY. Elsevier Science Ltd, New York, NY, USA, 248: 114314, (2022).

Dataset includes summary data for all endpoints measured in the experiments reported in the manuscript. This dataset is associated with the following publication: GUPTA, M., J. Conley, C. Lambright, L. Chin, S. HILL, L. Gray, and D. SPADE. Dose-response assessment of dipentyl phthalate effects on testosterone production and morphogenesis of late-gestation fetal rat testis. ENVIRONMENT INTERNATIONAL. Elsevier B.V., Amsterdam, NETHERLANDS, 200: 109551, (2025).

METADATA OUTLINE SHEET 1 STUDY INFORMATION SHEET 2 RANDOM ASSISNMENT OF PREGNANT RATS TO TREATMENT GROUPS SHEER 3 MATERNAL WEIGHT AND WEIGHT GAIN DURING DOSING and fetal DATA RAW DATA RESULTS PREDICTIONS OF DOSE ADDITIVITY SHEET 4 TESTOSTERONE (T PROD) DATA RAW DATA SAS INPUT FILES TREATMENT EFFECTS SHEET 5 CUSTOM GENE (mRNA) SAS INPUT FILE WITH SAS STATEMENTS AND RQW DATA SHEET 6 RESULTS FROM STATISTICAL ANALYSIS OF CUSTOM ARRAY mRNA DATA CUSTOM ARRAY: LIST OF GENES AND GENE DESCRIPTIONS SHEET 7 PREDICTION MODELS OF TESTOSTERONE PRODUCTION REDUCTIONS AND REPRODUCTIVE EFFECTS OF IN UTERO PHTHALATE EXPOSURE SHEET 8 TREATMENT EFFECTS PREDICTED FROM THE TESTOSTERONE PREDICTION MODELS COMPARISON OF THE PREDICTED EFFECTS OF THE DBP+DINP MIXTURE WITH OBSERVED EFFECTS OF THE REFERENCE CHEMICAL (DBP) AT EQUIVALENT DOSES, ASSUMING DOSE ADDITIVITY. This dataset is associated with the following publication: Gray, L., C. Lambright, N. Evans, J. Ford, and J. Conley. Using Targeted Fetal Rat Testis Genomic and Endocrine Alterations to Predict the Effects of a Phthalate Mixture on the Male Reproductive Tract.. Current Research in Toxicology. Elsevier B.V., Amsterdam, NETHERLANDS, 7: 100180, (2024).

data set has a description of the information in the excell file and all the data used in the study. This dataset is associated with the following publication: Gray, E., J. Conley, C. Lambright, and J. Furr. In utero exposure to a mixture of the perfluoroalkylisopropyl pesticide pyrifluquinazon with dibutyl phthalate cumulatively disrupts male rat reproductive development via different mechanisms of action. TOXICOLOGICAL SCIENCES. Society of Toxicology, RESTON, VA, 188(2): 234-247, (2022).

data set has a description of the information in the excell file and all the data used in the study. This dataset is associated with the following publication: Gray, E., J. Conley, C. Lambright, and J. Furr. In utero exposure to a mixture of the perfluoroalkylisopropyl pesticide pyrifluquinazon with dibutyl phthalate cumulatively disrupts male rat reproductive development via different mechanisms of action. TOXICOLOGICAL SCIENCES. Society of Toxicology, RESTON, VA, 188(2): 234-247, (2022).

DATA USED IN PAPER. This dataset is associated with the following publication: Gray, L. Biologically relevant reductions in fetal testosterone and Insl3 induced by in utero exposure to high levels of di-isononyl phthalate (DINP) in male rats. TOXICOLOGY AND APPLIED PHARMACOLOGY. Academic Press Incorporated, Orlando, FL, USA, 465(116454): 1, (2023).

DATA USED IN PAPER. This dataset is associated with the following publication: Gray, L. Biologically relevant reductions in fetal testosterone and Insl3 induced by in utero exposure to high levels of di-isononyl phthalate (DINP) in male rats. TOXICOLOGY AND APPLIED PHARMACOLOGY. Academic Press Incorporated, Orlando, FL, USA, 465(116454): 1, (2023).

Developmental toxicity of disinfection byproducts in F344 rats: effects on pregnancy maintenance and eye development. Data files for the experiments reported in the published journal article. Files include data for maternal body weights, gestation length, pup weights, number of implantation sites, and number of pups and litters affected with eye malformations. This dataset is associated with the following publication: Narotsky, M., L. Fuentes, O. Ola, T. Willoughby, and K. Lucas. Developmental Toxicity of Disinfection Byproducts in F344 Rats: Effects on Pregnancy Maintenance and Eye Development. Birth Defects Research. John Wiley & Sons, Inc., Hoboken, NJ, USA, 117(1): e2427, (2025).

Dataset contains summary data (mean, standard error, sample size (n)) for all measured endpoints reported and depicted in the corresponding manuscript. This dataset is associated with the following publication: Conley, J., C. Lambright, N. Evans, M. Strynar, J. McCord, B. McIntyre, G. Travlos, M. Cardon, E. MedlockKakaley, P. Hartig, V. Wilson, and E. Gray. Adverse maternal, fetal, and postnatal effects of Hexafluoropropylene oxide dimer acid (GenX) from oral gestational exposure in Sprague Dawley rats. ENVIRONMENTAL HEALTH PERSPECTIVES. National Institute of Environmental Health Sciences (NIEHS), Research Triangle Park, NC, USA, 1-13, (2019).