This file contains summary data of thyroid hormones in serum and brain in rat dams and their pups following maternal exposure to a perflorinated substance, PFHxS and an antimicrobial, Triclosan. Gene expression in thyroid glands and liver and brain were investigated. Anatomical and bahavioral indices of developmental neurotoxicity were assessed. Result so fall of these inquiries are summarized in these datasets. This dataset is associated with the following publication: Gilbert, M.E., K. OShaughnessy, S. Thomas, C. Riutta, C. Wood, A. Smith, W. Oshiro, J. Ford, A. Hotchkiss, I. Hassan, and R.L. Ford. Thyroid Disruptors: Extrathyroidal Sites of Chemical Action and Neurodevelopmental Outcome-An Examination Using Triclosan and Perfluorohexane Sulfonate. TOXICOLOGICAL SCIENCES. Society of Toxicology, RESTON, VA, 183(6): 195-213, (2021).

This dataset was generated to support parameterization of a larval amphibian thyroid axis computational model. Specifically, plasma iodine levels were determined not only to inform a concentration value for model parameter specification in the model, but also to support the notion that aquatic and terrestrial species should be considered substantially different with regard to circulating iodide levels. Other computational model physical parameters were informed by evaluating Xenopus laevis thyroid gland histological images for morphological features including thyroid follicular cell numbers and areas. This dataset is associated with the following publication: Haselman, J., J. Nichols, K. Mattingly, M. Hornung, and S. Degitz. A biologically based computational model for the hypothalamic-pituitary-thyroid (HPT) axis in Xenopus laevis larvae. MATHEMATICAL BIOSCIENCES. Elsevier Science Ltd, New York, NY, USA, 362: 109021, (2023).

Data associated with the Adams et al. manuscript "Elevated winter stream temperatures below wastewater treatment plants shift female reproductive development of Johnny Darter Etheostoma nigrum: a field and histologic approach." Data include in vitro estrogen receptor agonist activities of surface water samples and vitellogenin gene expression in Johnny Darter liver samples. This dataset is associated with the following publication: Adams, C., D. Winkelman, P. Schaffer, R. Fitzpatrick, J. Cavallin, M. Ellman, K. Santana Rodriguez, and D. Villeneuve. Elevated winter stream temperatures below wastewater treatment plants shift reproductive development of Johnny Darter Etheostoma nigrum: a field and histologic approach. Fishes. MDPI, Basel, SWITZERLAND, N/A, (2022).

Iodide uptake following a two-hour incubation with concentrations of 5-ATcompared to control iodide uptake in FRTL thyroid follicular cells. This dataset is associated with the following publication: Adams, V., M. Bazar, E. Reinke, A. Buckalew, and W. Eck. In vitro and in vivo effects of 5-Aminotetrazole (5-AT)- an energetic compound. REGULATORY TOXICOLOGY AND PHARMACOLOGY. Elsevier Science Ltd, New York, NY, USA, 111(104573): 1, (2020).

This is a manuscript developed by a group at University of Berlin and Danish Technical University, using previously published data from EPA. The only EPA interaction has been providing advice on how to correctly use the data. This dataset is not publicly accessible because: The data were not collected by EPA and are hosted external to the agency. It can be accessed through the following means: Contact the corresponding author Yasmine Emara at the Department of Environmental Technology, Technical University Berlin, 10623 Berlin, Germany. Email: y.emara@tu-berlin.de. Format: Not available. This dataset is associated with the following publication: Emara, Y., P. Fantke, R. Judson, X. Chang, P. Pradeep, A. Lehmann, M. Siegert, and M. Finkbeiner. Integrating endocrine-related health effects into comparative human toxicity characterization. SCIENCE OF THE TOTAL ENVIRONMENT. Elsevier BV, AMSTERDAM, NETHERLANDS, 762: 143874, (2021).

Raw data to accompanying manuscript "The Pollutant Perfluorohexane Sulfonate (PFHxS) Reduces Serum Thyroxine but Does Not Alter Thyroid Hormone Action in the Postnatal Rat Brain". This dataset is associated with the following publication: O'Shaughnessy, K., K. Bell, A. Sasser, M. Gilbert, C. Riutta, J. Ford, J. McCord, and C. Wood. The Pollutant Perfluorohexane Sulfonate (PFHxS) Reduces Serum Thyroxine but Does Not Alter Thyroid Hormone Action in the Postnatal Rat Brain. ENVIRONMENT INTERNATIONAL. Elsevier B.V., Amsterdam, NETHERLANDS, 190: 108838, (2024).

Dataset contains summary data (mean +/- error) for all endpoints measured in published studies. This dataset is associated with the following publication: Conley, J., C. Lambright, N. Evans, E. Medlock Kakaley, D. Jenkins-Hill, J. McCord, M. Strynar, L. Wehmas, S. Hester, D. Macmillan, and L. Gray. Developmental toxicity of Nafion byproduct 2 (NBP2) in the Sprague-Dawley rat with comparisons to hexafluoropropylene oxide-dimer acid (HFPO-DA or GenX) and perfluorooctane sulfonate (PFOS). ENVIRONMENT INTERNATIONAL. Elsevier B.V., Amsterdam, NETHERLANDS, 160(107056): 1, (2022).

effects of in utero phthalate and other chemical administration on male rat sexual differentiation: Non PPAR mediated AOP. This dataset is associated with the following publication: Gray, E., J. Conley, C. Lambright, N. Evans, J. Furr, V. Wilson, B. Hannas, P. Foster, and H. Sampson. Genomic and Hormonal Biomarkers of Phthalate-induced Male Rat Reproductive Developmental Toxicity: Part II A Targeted RT-qPCR Array Approach that Defines a Unique Adverse Outcome Pathway.. TOXICOLOGICAL SCIENCES. Society of Toxicology, RESTON, VA, 182(2): 195-214, (2021).

How to access data for "Decrane R, Stoker T, Murr A, Ford J, El-Masri H. Cross species extrapolation of the disruption of thyroid hormone synthesis by oxyfluorfen using in vitro data, physiologically based pharmacokinetic (PBPK), and thyroid hormone kinetics models. Curr Res Toxicol. 2023 Nov 23;5:100138. doi: 10.1016/j.crtox.2023.100138. PMID: 38074188; PMCID: PMC10697989.". This dataset is not publicly accessible because: N/A. It can be accessed through the following means: Data will be made available on request from Hisham El-Masri (el-masri.hisham@epa.gov). Format: N/A. This dataset is associated with the following publication: Decrane, R., T. Stoker, A. Murr, J. Ford, and H. El-Masri. Cross species extrapolation of the disruption of thyroid hormone synthesis by oxyfluorfen using in vitro data, physiologically based pharmacokinetic (PBPK), and thyroid hormone kinetics models. Current Research in Toxicology. Elsevier B.V., Amsterdam, NETHERLANDS, 5: 100138, (2023).

Dataset for "Incorporating human exposure information in a weight of evidence approach to inform design of repeated dose animal studies". This dataset is associated with the following publication: Lowe, K., J. Dawson, K. Phillips, J. Minucci, J. Wambaugh, H. Qian, T. Ramanarayanan, P. Egeghy, B. Ingle, R. Brunner, E. Mendez, M. Embry, and C. Tan. Incorporating human exposure information in a weight of evidence approach to inform design of repeated dose animal studies. REGULATORY TOXICOLOGY AND PHARMACOLOGY. Elsevier Science Ltd, New York, NY, USA, 127: 105073, (2021).