Iodide uptake following a two-hour incubation with concentrations of 5-ATcompared to control iodide uptake in FRTL thyroid follicular cells. This dataset is associated with the following publication: Adams, V., M. Bazar, E. Reinke, A. Buckalew, and W. Eck. In vitro and in vivo effects of 5-Aminotetrazole (5-AT)- an energetic compound. REGULATORY TOXICOLOGY AND PHARMACOLOGY. Elsevier Science Ltd, New York, NY, USA, 111(104573): 1, (2020).

Data pertaining to a NIS-expressing cell line, FRTL-5 and it's screening capabilities for confirming inhibitors of NIS-mediated iodide uptake. This dataset is associated with the following publication: Buckalew, A., J. Wang, A. Murr, C. Deisenroth, W. Stewart, T. Stoker, and S. Laws. Evaluation of potential sodium-iodide symporter (NIS) inhibitors using a secondary Fischer rat thyroid follicular cell (FRTL-5) radioactive iodide uptake (RAIU) assay. Archives of Toxicology. Springer, New York, NY, USA, 94(3): 873-885, (2020).

Data pertaining to a NIS-expressing cell line, hNIS-HEK293T-EPA, and its screening capabilities for determining inhibitors of NIS-mediated iodide uptake. This dataset is associated with the following publication: Hallinger, D., A. Murr, A. Buckalew, S. Simmons, T. Stoker, and S. Laws. Development of a Screening Approach to Detect Thyroid Disrupting Chemicals that Inhibit the Human Sodium/Iodide Symporter (NIS). TOXICOLOGY IN VITRO. Elsevier Science Ltd, New York, NY, USA, 66-78, (2017).

Data pertaining to a NIS-expressing cell line, hNIS-HEK293T-EPA, and its screening capabilities for determining inhibitors of NIS-mediated iodide uptake. This dataset is associated with the following publication: Hallinger, D., A. Murr, A. Buckalew, S. Simmons, T. Stoker, and S. Laws. Development of a Screening Approach to Detect Thyroid Disrupting Chemicals that Inhibit the Human Sodium/Iodide Symporter (NIS). TOXICOLOGY IN VITRO. Elsevier Science Ltd, New York, NY, USA, 66-78, (2017).

Dataset for the publication "Expanded High-Throughput Screening and Chemotype-Enrichment Analysis of the Phase II:e1k ToxCast Library for Human Sodium-Iodide Symporter (NIS) Inhibition". https://doi.org/10.1007/s00204-021-03006-2 Dataset1 contains data for figures. Dataset2 contains all supplemental tables data. This dataset is associated with the following publication: Wang, J., A. Richard, A. Murr, A. Buckalew, R. Lougee, M.A. Shobair, D. Hallinger, S. Laws, and T. Stoker. Expanded High-Throughput Screening and Chemotype-Enrichment Analysis of the Phase II:e1k ToxCast Library for Human Sodium-Iodide Symporter (NIS) Inhibition. Archives of Toxicology. Springer, New York, NY, USA, 95(5): 1723-1737, (2021).

Supplementary data for "Stephanie A. Eytcheson, Jennifer H. Olker, Katie Paul Friedman, Michael W. Hornung, Sigmund J. Degitz, Assessing utility of thyroid in vitro screening assays through comparisons to observed impacts in vivo, Regulatory Toxicology and Pharmacology, Volume 144, 2023, 105491, ISSN 0273-2300, https://doi.org/10.1016/j.yrtph.2023.105491.". Portions of this dataset are inaccessible because: N/A. They can be accessed through the following means: N/A. Format: The data used in this analysis are from publicly available sources and are cited in the references and/or the supplemental files. This dataset is associated with the following publication: Eytcheson, S., J. Olker, K. Friedman, M. Hornung, and S. Degitz. Assessing utility of thyroid in vitro screening assays through comparisons to observed impacts in vivo. REGULATORY TOXICOLOGY AND PHARMACOLOGY. Elsevier Science Ltd, New York, NY, USA, 144: 105491, (2023).

This excel file contains the resultant data from a study on iodotyrosine deiodinase in the model amphibian species, Xenopus laevis. These data include: tadpole growth and development, thyroid hormones in plasma and glands, and expression of thyroid-relevant genes. The initial worksheet tab that provides metadata for each dataset included in the other worksheets that make up the file. This dataset is associated with the following publication: Olker, J., J. Haselman, P. Kosian, K. Donnay, J. Korte, C. Blanksma, M. Hornung, and S. Degitz. Evaluating iodide recycling inhibition as a novel molecular initiating event for thyroid axis disruption in amphibians. TOXICOLOGICAL SCIENCES. Society of Toxicology, RESTON, VA, 166(2): 318-331, (2018).

This excel file contains the resultant data from a study on iodotyrosine deiodinase in the model amphibian species, Xenopus laevis. These data include: tadpole growth and development, thyroid hormones in plasma and glands, and expression of thyroid-relevant genes. The initial worksheet tab that provides metadata for each dataset included in the other worksheets that make up the file. This dataset is associated with the following publication: Olker, J., J. Haselman, P. Kosian, K. Donnay, J. Korte, C. Blanksma, M. Hornung, and S. Degitz. Evaluating iodide recycling inhibition as a novel molecular initiating event for thyroid axis disruption in amphibians. TOXICOLOGICAL SCIENCES. Society of Toxicology, RESTON, VA, 166(2): 318-331, (2018).

The excel spreadsheet contains the resultant data from an assay for chemical inhibition of human Iodotyrosine Deiodinase (IYD) enzyme activity screened against the ToxCast Phase 1_v2, Phase 2, and e1k chemical libraries, as well as a few additional target chemicals from ToxCast Phase 3 library or used in assay development. Over 1,800 chemicals were tested in total. This data set includes the list of chemicals tested and the median, minimum, and maximum inhibition produced by each chemical when screened at target high concentration of 200 µM. 154 chemicals were further tested in concentration response, and the median, minimum, and maximum inhibition produced at each concentration for those chemicals are included. A model inhibitor (3-Nitro-L-Tyrosine) was included on each plate as a positive control, with concentration response data for those curves also included in the data set. This dataset is associated with the following publication: Olker, J., J. Korte, J. Denny, J. Haselman, P. Hartig, M. Cardon, M. Hornung, and S. Degitz. In Vitro Screening for Chemical Inhibition of the Iodide Recycling Enzyme, Iodotyrosine Deiodinase. TOXICOLOGY IN VITRO. Elsevier Science Ltd, New York, NY, 71: 105073, (2021).

The excel spreadsheet contains the resultant data from an assay for chemical inhibition of human Iodotyrosine Deiodinase (IYD) enzyme activity screened against the ToxCast Phase 1_v2, Phase 2, and e1k chemical libraries, as well as a few additional target chemicals from ToxCast Phase 3 library or used in assay development. Over 1,800 chemicals were tested in total. This data set includes the list of chemicals tested and the median, minimum, and maximum inhibition produced by each chemical when screened at target high concentration of 200 µM. 154 chemicals were further tested in concentration response, and the median, minimum, and maximum inhibition produced at each concentration for those chemicals are included. A model inhibitor (3-Nitro-L-Tyrosine) was included on each plate as a positive control, with concentration response data for those curves also included in the data set. This dataset is associated with the following publication: Olker, J., J. Korte, J. Denny, J. Haselman, P. Hartig, M. Cardon, M. Hornung, and S. Degitz. In Vitro Screening for Chemical Inhibition of the Iodide Recycling Enzyme, Iodotyrosine Deiodinase. TOXICOLOGY IN VITRO. Elsevier Science Ltd, New York, NY, 71: 105073, (2021).