,Influenza A virus is a major respiratory pathogen in swine that leads to significant economic loss in the swine industry, and there is a critical need to improve on commercial vaccines. Traditional vaccines target the hemagglutinin (HA) portion of the IAV virus, lose protection to as viruses change, and may even lead to vaccine-associated enhanced respiratory disease (VAERD) after infection with a dissimilar influenza virus. A newer replicon particle (RP) vaccine platform targeting the influenza HA protein offers multiple advantages over traditional vaccines for swine, but have not yet been evaluated for the ability to avoid VAERD or the use of HA along with an additional viral vaccine target, such as neuraminidase (NA). In this work we demonstrated RP HA and NA influenza vaccines stimulate immune responses, protect from disease, and avoid VAERD following infection with a distantly related virus. This demonstrates the potential utility of RP vaccines against influenza and the importance in utilizing the NA in influenza vaccine design. Such improvement of IAV vaccines will reduce influenza disease and economic loss in commercial swine and reduce the risk of influenza transmission to people. These data include individual pig responses used in statistical analyses and figures to support the conclusions of the paper.,,

,The dataset includes clinical data from an experimental swine and ferret challenge and transmission study with 3 strains of swine H1 influenza A virus. Data are presented in two spreadsheets, one for pigs and one for ferrets.,,

,Influenza A virus in swine hemagglutinin (HA) gene sequence data for 9 virus strains.,,

,An investigation of antigenic relationships between North American swine H3N2 influenza A viruses (IAV) and human seasonal vaccine strains was conducted to assess the zoonotic risk to humans. Human seasonal H3N2 vaccine strains isolated from 1973 to 2014 (n=20) were obtained from the World Health Organization Global Influenza Surveillance and Response Network through St. Jude Children’s Research Hospital to use for serological assays, such as hemagglutination inhibition (HI) assays. Human seasonal vaccine strains were cultured on MDCK cells or eggs and the HA gene was verified by sequencing on a Sanger method at National Animal Disease Center (NADC). A consensus HA sequence was generated using Geneious Software.,

,Changes in influenza viruses that infect pigs have been observed for over two decades. The evolution of these viruses has led to several new strains. For instance, one such strain known as H1N2 emerged to infect pigs in the United States in 2015. This virus recently gained prevalence after acquiring a new N1 gene. Our study aimed to determine if the new N1 gene was responsible for increased transmission of the virus among pigs. To investigate this hypothesis, we analyzed four different strains of H1N1 or H1N2 influenza A virus. Each strain had different combinations of N1 and N2 genes. We infected pigs with these viruses and observed their clinical signs as well as transmission to other pigs. Regardless of the viral genes present, all variants of the virus were transmitted from one infected pig to another at the same levels. Therefore, the new N1 gene did not seem to have direct importance in increasing the transmission of the virus. These results suggest that the increase in detection may be associated with less protection from previous vaccines or infections due to the change in N1 or N2, or changes related to pig management or movement. Understanding how influenza A viruses spread provides important insights for the swine industry for disease prevention and vaccine developers for vaccine strain selection.,

This dataset contains the following files for California influenza surveillance data: 1) Outpatient Influenza-like Illness Surveillance Data by Region and Influenza Season from volunteer sentinel providers; 2) Clinical Sentinel Laboratory Influenza and Other Respiratory Virus Surveillance Data by Region and Influenza Season from volunteer sentinel laboratories; and 3) Public Health Laboratory Influenza Respiratory Virus Surveillance Data by Region and Influenza Season from California public health laboratories. The Immunization Branch at the California Department of Public Health (CDPH) collects, compiles and analyzes information on influenza activity year-round in California and produces a weekly influenza surveillance report during October through May. The California influenza surveillance system is a collaborative effort between CDPH and its many partners at local health departments, public health and clinical laboratories, vital statistics offices, healthcare providers, clinics, emergency departments, and the Centers for Disease Control and Prevention (CDC). California data are also included in the CDC weekly influenza surveillance report, FluView, and help contribute to the national picture of Influenza activity in the United States. The information collected allows CDPH and CDC to: 1) find out when and where influenza activity is occurring; 2) track influenza-related illness; 3) determine what influenza viruses are circulating; 4) detect changes in influenza viruses; and 5) measure the impact influenza is having on hospitalizations and deaths.

This dataset contains the following files for California influenza surveillance data: 1) Outpatient Influenza-like Illness Surveillance Data by Region and Influenza Season from volunteer sentinel providers; 2) Clinical Sentinel Laboratory Influenza and Other Respiratory Virus Surveillance Data by Region and Influenza Season from volunteer sentinel laboratories; and 3) Public Health Laboratory Influenza Respiratory Virus Surveillance Data by Region and Influenza Season from California public health laboratories. The Immunization Branch at the California Department of Public Health (CDPH) collects, compiles and analyzes information on influenza activity year-round in California and produces a weekly influenza surveillance report during October through May. The California influenza surveillance system is a collaborative effort between CDPH and its many partners at local health departments, public health and clinical laboratories, vital statistics offices, healthcare providers, clinics, emergency departments, and the Centers for Disease Control and Prevention (CDC). California data are also included in the CDC weekly influenza surveillance report, FluView, and help contribute to the national picture of Influenza activity in the United States. The information collected allows CDPH and CDC to: 1) find out when and where influenza activity is occurring; 2) track influenza-related illness; 3) determine what influenza viruses are circulating; 4) detect changes in influenza viruses; and 5) measure the impact influenza is having on hospitalizations and deaths.

Persons aged 65 and over immunised against Influenza between October and January. Related links: http://www.hscic.gov.uk/Article/1685 http://www.hscic.gov.uk/searchcatalogue?q=title%3A%22NHS+Immunisation+Statistics%22&area=&size=10&sort=RelevanceDesc

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