This dataset provides exposure and effects data for two experiments regarding the dietborne toxicity of inorganic arsenic and selected organoarsenicals on rainbow trout survival and growth. There are separate spreadsheets for the two experiments, at the replicate exposure chamber level, of measured fish weights and survival and calculated growth metrics. Each spreadsheet provides footnote descriptions of the data and calculations provided. Descriptions of experimental protocols are also provided as supporting documents. This dataset is associated with the following publication: Erickson, R., D. Mount, T. Highland, R. Hockett, D. Hoff, C. Jenson, and T. Lahren. The effects of arsenic speciation on accumulation and toxicity of dietborne arsenic exposures to rainbow trout.. AQUATIC TOXICOLOGY. Elsevier Science Ltd, New York, NY, USA, 210: 227-241, (2019).

This dataset provides exposure and effects data for two experiments regarding the dietborne toxicity of inorganic arsenic and selected organoarsenicals on rainbow trout survival and growth. There are separate spreadsheets for the two experiments, at the replicate exposure chamber level, of measured fish weights and survival and calculated growth metrics. Each spreadsheet provides footnote descriptions of the data and calculations provided. Descriptions of experimental protocols are also provided as supporting documents. This dataset is associated with the following publication: Erickson, R., D. Mount, T. Highland, R. Hockett, D. Hoff, C. Jenson, and T. Lahren. The effects of arsenic speciation on accumulation and toxicity of dietborne arsenic exposures to rainbow trout.. AQUATIC TOXICOLOGY. Elsevier Science Ltd, New York, NY, USA, 210: 227-241, (2019).

The US Environmental Protection Agency conducts ecological risk assessments with a battery of fish toxicity tests that include acute, early life stage, and reproduction tests. While endpoints in these tests (survival, growth and reproduction) are conceptually related, because they are measured in separate exposures, the quantitative relationships between them are difficult to determine and largely ignored. In the current test, fathead minnows (FHM) were exposed for 28 days to 1 mg/L or 2 mg/L carbaryl, a well-studied carbamate insecticide, in early life stages and then reared in clean water until adulthood, when reproduction was assessed. Also. weekly growth measurements were taken throughout the test to determine growth rates during and after exposure. Growth curves derived from these measurements were then compared to the reproductive output. The data indicate that carbaryl reduced growth rate only for a brief time early in the exposure. However, this brief effect impacted overall growth into adulthood and lowered the reproductive output of exposed FHM. The effect of a transient exposure early in life to carbaryl could have later population-level impacts by causing mortality, lowering growth rates, and reducing reproductive output. This dataset is associated with the following publication: Flynn, K., S. Kadlec, V. Kurker, and M. Etterson. Effects of a 28-day early life stage exposure to carbaryl on fathead minnow long-term growth and reproduction. AQUATIC TOXICOLOGY. Elsevier Science Ltd, New York, NY, USA, 242: 106018, (2022).

The US Environmental Protection Agency conducts ecological risk assessments with a battery of fish toxicity tests that include acute, early life stage, and reproduction tests. While endpoints in these tests (survival, growth and reproduction) are conceptually related, because they are measured in separate exposures, the quantitative relationships between them are difficult to determine and largely ignored. In the current test, fathead minnows (FHM) were exposed for 28 days to 1 mg/L or 2 mg/L carbaryl, a well-studied carbamate insecticide, in early life stages and then reared in clean water until adulthood, when reproduction was assessed. Also. weekly growth measurements were taken throughout the test to determine growth rates during and after exposure. Growth curves derived from these measurements were then compared to the reproductive output. The data indicate that carbaryl reduced growth rate only for a brief time early in the exposure. However, this brief effect impacted overall growth into adulthood and lowered the reproductive output of exposed FHM. The effect of a transient exposure early in life to carbaryl could have later population-level impacts by causing mortality, lowering growth rates, and reducing reproductive output. This dataset is associated with the following publication: Flynn, K., S. Kadlec, V. Kurker, and M. Etterson. Effects of a 28-day early life stage exposure to carbaryl on fathead minnow long-term growth and reproduction. AQUATIC TOXICOLOGY. Elsevier Science Ltd, New York, NY, USA, 242: 106018, (2022).

Given that larval fish stages provide opportunities for development of stressor-selective screening level tests, this work aimed to investigate the optimal age of fathead minnow larva and duration of exposure for the pharmaceutical, propranolol, found in the environment. Differentially expressed genes were studied as well as gene set enrichment analysis. This dataset is associated with the following publication: Biales, A., D. Bencic, R. Flick, and G. Toth. Effects of Age and Exposure Duration on the Sensitivity of Early Life Stage Fathead Minnow (Pimephales promelas) to Waterborne Propranolol Exposure. ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY. Society of Environmental Toxicology and Chemistry, Pensacola, FL, USA, 43(4): 807-820, (2024).

This data set describes developmental and physiological effects observed in fathead minnow embryos that were exposed to sodium nitrate or conductivity-matched controls. Exposures were conducted in the laboratory from fertilization through 21 days post-fertilization (dpf). Nitrate doses were 0, 2, 5, 10, 25, or 100 milligrams per liter nitrate-nitrogen; conductivity controls were matched to the 10 and 100 milligrams per liter nitrate-nitrogen treatments. During the experiment, we assessed heart rate and percent arrhythmic heart beats at 3 dpf, timing of hatch and inflation of the posterior and anterior swim bladders, presence of pericardial edema or scoliosis, fish metrics at 21 dpf (fish length and weight; swim bladder length, width, and volume), and mortality. Water quality data during the exposure period are also presented, and include conductivity, pH, nitrate-nitrogen, total ammonia, unionized ammonia, and dissolved oxygen.

This data set describes developmental and physiological effects observed in fathead minnow embryos that were exposed to sodium nitrate or conductivity-matched controls. Exposures were conducted in the laboratory from fertilization through 21 days post-fertilization (dpf). Nitrate doses were 0, 2, 5, 10, 25, or 100 milligrams per liter nitrate-nitrogen; conductivity controls were matched to the 10 and 100 milligrams per liter nitrate-nitrogen treatments. During the experiment, we assessed heart rate and percent arrhythmic heart beats at 3 dpf, timing of hatch and inflation of the posterior and anterior swim bladders, presence of pericardial edema or scoliosis, fish metrics at 21 dpf (fish length and weight; swim bladder length, width, and volume), and mortality. Water quality data during the exposure period are also presented, and include conductivity, pH, nitrate-nitrogen, total ammonia, unionized ammonia, and dissolved oxygen.

Data for "Flynn, K., Le, M., Hazemi, M. et al. Comparing Transcriptomic Points of Departure to Apical Effect Concentrations For Larval Fathead Minnow Exposed to Chemicals with Four Different Modes Of Action. Arch Environ Contam Toxicol 86, 346–362 (2024). https://doi.org/10.1007/s00244-024-01064-y". Portions of this dataset are inaccessible because: N/A. They can be accessed through the following means: All sequence data reported in this manuscript are accessible via the Gene Expression Omnibus (BioProject PRJNA104613). Format: N/A. This dataset is associated with the following publication: Flynn, K., M. Le, M. Hazemi, A. Biales, D. Bencic, B. Blackwell, K. Bush, R. Flick, J. Hoang, J. Martinson, M. Morshead, K. Santana Rodriguez, E. Stacy, and D. Villeneuve. Comparing Transcriptomic Points of Departure to Apical Effect Concentrations For Larval Fathead Minnow Exposed to Chemicals with Four Different Modes Of Action. ARCHIVES OF ENVIRONMENTAL CONTAMINATION AND TOXICOLOGY. Springer, New York, NY, USA, 86(4): 346-362, (2024).