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ConleyJustin A-b5mz Dataset 20201021
This dataset is limited to the human counting values of multinucleated germ cells in treatment-blinded images of rat fetal testes conducted by EPA researcher Justin Conley for comparison by collaborators at Brown University to germ cell counts made using an automated method created by the collaborators. This dataset is associated with the following publication: Bell, S., A. Zsom, J. Conley, and D. Spade. Automated identification of multinucleated germ cells with U-Net. PLoS ONE. Public Library of Science, San Francisco, CA, USA, 15(7): e0229967, (2020).
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Validation of an automated counting procedure for phthalate-induced testicular multinucleated germ cells
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the dataset contains NHEERL collected data on fetal male rat gestational day 18 testicular testosterone production and related data. This dataset is associated with the following publication: spade, d., C. Yue Bai , C. Lambright, J. Conley, K. Boekelheide , and E. Gray. Validation of an automated counting procedure for phthalate-induced testicular multinucleated germ cells. TOXICOLOGY LETTERS. Elsevier Science Ltd, New York, NY, USA, 290: 55-61, (2018).
Gray 2025 Phthalate transcriptomic and apical points of departure dataset
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Dataset includes all endpoint measurements from studies described in the manuscript and SAS code for statistical analyses of data. This dataset is associated with the following publication: Gray, L., C. Lambright, N. Evans, J. Ford, and J. Conley. Comparison of in utero phthalate exposure on fetal rat testis transcript and endocrine alterations with apical reproductive alterations in male rats. TOXICOLOGY AND APPLIED PHARMACOLOGY. Elsevier B.V., Amsterdam, NETHERLANDS, 502: 117447, (2025).
IN UTERO EFFECTS OF ORAL SIMVASTATIN ON THE CRSD RAT DAM, DETUS AND OFFSPRING LATER IN LIFE
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DATA FROM THE MANUSCRIPT BY BEVERLY ET AL 2019 FOR ALL TABLES AND FIGURES. This dataset is associated with the following publication: Beverly, B., J. Furr , C. Lambright , V. Wilson , B. MCINTYRE, P. FOSTER, G. TRAVLOS, and E. Gray. In utero exposure to Simvastatin reduces postnatal survival and permanently alters reproductive tract development in the CRL:CD(SD) male rat. TOXICOLOGY AND APPLIED PHARMACOLOGY. Academic Press Incorporated, Orlando, FL, USA, 112-123, (2019).
Adverse maternal, fetal, and neonatal effects of GenX from oral gestational exposure in Sprague Dawley rats Dataset
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Dataset contains summary data (mean, standard error, sample size (n)) for all measured endpoints reported and depicted in the corresponding manuscript. This dataset is associated with the following publication: Conley, J., C. Lambright, N. Evans, M. Strynar, J. McCord, B. McIntyre, G. Travlos, M. Cardon, E. MedlockKakaley, P. Hartig, V. Wilson, and E. Gray. Adverse maternal, fetal, and postnatal effects of Hexafluoropropylene oxide dimer acid (GenX) from oral gestational exposure in Sprague Dawley rats. ENVIRONMENTAL HEALTH PERSPECTIVES. National Institute of Environmental Health Sciences (NIEHS), Research Triangle Park, NC, USA, 1-13, (2019).
Ramjoh PFHxS Data
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File contains data on body, liver, thyroid weights from dams and exposed offspring, serum thyroid hormones, gland and cortical gene expression, results of cognitive function tests. This dataset is associated with the following publication: Ramhoj, L., U. Haas, M. Gilbert, C. Wood, T. Svingen, D. Usai, A.M. Vinggaard, K. Mandrup, and M. Axelstad. Evaluating thyroid hormone disruption: Investigations of long-term neurodevelopmental effects in rats after perinatal exposure to perfluorohexane sulfonate (PFHxS). Scientific Reports. Nature Publishing Group, London, UK, 10(1): 2672, (2020).
excell file with metadata sheet and data from the PFQ and BPC paper
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this file has the metadata sheet and the data used for the figures and tables in the PFQ vs BPC manuscript. This dataset is associated with the following publication: Gray, E., J. Furr, J. Conley, C. Lambright, N. Evans, M. Cardon, V. Wilson, P. Foster, and P. Hartig. A Conflicted Tale of Two Novel AR Antagonists In vitro and In vivo: Pyrifluquinazon versus Bisphenol C.. TOXICOLOGICAL SCIENCES. Society of Toxicology, RESTON, VA, 632-643, (2019).
Triclosan Hershberger H295 data
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Triclosan data from Hershberger experiment using castrated male rats. Data includes accessory sex tissue mean weights and thyroid gland weight following exposure to triclosan for 10 days both with and without testosterone stimulation. Also included are the thyroxine hormone means in these males. In addition, mean data on the in vitro adrenocortical cells for steroid hormone production (testosterone and estradiol) with a dose response of triclosan. This dataset is associated with the following publication: Farmer, W., G. Louis, A. Buckalew, D. Hallinger, and T. Stoker. Evaluation of Triclosan in the Hershberger and H295R Steroidogenesis Assays. TOXICOLOGY LETTERS. Elsevier Science Ltd, New York, NY, USA, 194-199, (2018).
Data for Brown et al MEA Developmental Neurotoxicity Screening Manuscript
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These data are the individual parameter and well-level data that were support the conclusions in Brown et al. Note: the parameters CVtime and CVnetwork were not used. This dataset is associated with the following publication: Brown, J., D. Hall, C. Frank, K. Wallace, W. Mundy, and T. Shafer. Editor's highlight: Evaluation of a Microelectrode Array-based Assay for Neural Network Ontogeny using Training Set Chemicals. TOXICOLOGICAL SCIENCES. Society of Toxicology, 154(1): 126-139, (2016).
Supplimental data
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An Excel file including: raw data, data dictionary, and all final data sets. A PDF containing detailed equations for calculating the daily dose using the creatinine correction and UFR, figures comparing the HI between the creatinine correction and UFR, figures and tables comparing temporal trends in the MCR between the HI and potency-weighted approach, tables describing frequency of participants by cycle, temporal limit of detection by metabolite, tolerable daily intakes by phthalate, Group designation of the MCR, complete regression equations used in the regression analysis, comparison of Group counts by creatinine correction and UFR, and relative potency factors by phthalate. This dataset is associated with the following publication: Reyes, J., and P. Price. Temporal Trends in Exposures to Six Phthalates from Biomonitoring Data: Implications for Cumulative Risk. ENVIRONMENTAL SCIENCE & TECHNOLOGY. American Chemical Society, Washington, DC, USA, 52(21): 12475-12483, (2018).
Tools to Minimize Inter-Laboratory Variability in Vitellogenin Gene Expression Monitoring Programs
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All data files are in excel format. Files with names CSU are different mesocosms qPCR data results for vitellogen gene and 18s a house keeping gene. Data files labelled ORD are qPCR data generated by NERL Cincinnati. Those labeled R5 are qPCR data generated by EPA’s Region 5 lab and RMI_Mass are qPCR data generated by the University of Massachusetts Amherst. This dataset is associated with the following publication: Jastrow , A., D. Gordon , K. Auger, E. Punska, K. Arcaro, K. Keteles , D. Winkleman, D. Lattier , A. Biales , and J. Lazorchak. Tools to minimize interlaboratory variability in vitellogenin gene expression monitoring programs. ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY. Society of Environmental Toxicology and Chemistry, Pensacola, FL, USA, 36(11): 3102-3107, (2017).