In this study, we investigated effects of inhaled ozone exposure and high-cholesterol diet (HCD) in healthy Wistar and Wistar-derived Goto-Kakizaki (GK) rats, a non-obese model of type 2 diabetes. Male rats (4-week old) were fed normal diet or HCD for 12 weeks and then exposed to filtered air or 1.0 ppm ozone (6hrs/day) for 1 or 2 days. We examined pulmonary, vascular, hematology, and inflammatory responses after each exposure plus an 18-hr recovery period. This dataset is associated with the following publication: Snow, S., A. Henriquez, L. Thompson, C. Fisher, M.C. Schladweiler, C. Wood, and U. Kodavanti. Pulmonary and Vascular Effects of Acute Ozone Exposure in Diabetic Rats Fed an Atherogenic Diet. TOXICOLOGY AND APPLIED PHARMACOLOGY. Academic Press Incorporated, Orlando, FL, USA, 415(115430): 1, (2021).

In this study, we investigated effects of inhaled ozone exposure and high-cholesterol diet (HCD) in healthy Wistar and Wistar-derived Goto-Kakizaki (GK) rats, a non-obese model of type 2 diabetes. Male rats (4-week old) were fed normal diet or HCD for 12 weeks and then exposed to filtered air or 1.0 ppm ozone (6hrs/day) for 1 or 2 days. We examined pulmonary, vascular, hematology, and inflammatory responses after each exposure plus an 18-hr recovery period. This dataset is associated with the following publication: Snow, S., A. Henriquez, L. Thompson, C. Fisher, M.C. Schladweiler, C. Wood, and U. Kodavanti. Pulmonary and Vascular Effects of Acute Ozone Exposure in Diabetic Rats Fed an Atherogenic Diet. TOXICOLOGY AND APPLIED PHARMACOLOGY. Academic Press Incorporated, Orlando, FL, USA, 415(115430): 1, (2021).

This data set includes individual animal data collected for various biological endpoints that are included in the manuscript. Miller DB, Snow SJ, Henriquez A, Schladweiler MC, Ledbetter AD, Richards JE, Andrews DL, Kodavanti UP. Systemic metabolic derangement, pulmonary effects, and insulin insufficiency following subchronic ozone exposure in rats. Toxicol Appl Pharmacol. 2016 Jun 28;306:47-57. The primary author Desinia Miller, an UNC-EPA co-opp Student has since completed her PhD and is no longer in EPA database. This dataset is associated with the following publication: Miller, D., S. Snow, A. Henriquez, M. Schladweiler, A. Ledbetter, J. Richards, D. Andrews, and U. Kodavanti. Systemic Metabolic Derangement, Pulmonary Effects, and Insulin Insufficiency following subchronic ozone exposure in rats. TOXICOLOGY AND APPLIED PHARMACOLOGY. Academic Press Incorporated, Orlando, FL, USA, 306: 47-57, (2016).

Data from Prenatal ozone exposure programs a sexually dimorphic susceptibility to high fat diet in adolescent Long-Evans rats. This dataset is associated with the following publication: Stewart, E., J. Dye, M. Schladweiler, P. Phillips, K. McDaniel, J. Richards, R. Grindstaff, W. Padgett, M. Moore, D. Jenkins-Hill, C. Gordon, U. Kodavanti, and C. Miller. Prenatal ozone exposure programs a sexually dimorphic susceptibility to high fat diet in adolescent Long-Evans rats.. FASEB JOURNAL. Federation of American Societies for Experimental Biology (FASEB), Bethesda, MD, USA, 36(12): e22664, (2022).

Data from Prenatal ozone exposure programs a sexually dimorphic susceptibility to high fat diet in adolescent Long-Evans rats. This dataset is associated with the following publication: Stewart, E., J. Dye, M. Schladweiler, P. Phillips, K. McDaniel, J. Richards, R. Grindstaff, W. Padgett, M. Moore, D. Jenkins-Hill, C. Gordon, U. Kodavanti, and C. Miller. Prenatal ozone exposure programs a sexually dimorphic susceptibility to high fat diet in adolescent Long-Evans rats.. FASEB JOURNAL. Federation of American Societies for Experimental Biology (FASEB), Bethesda, MD, USA, 36(12): e22664, (2022).

In this study male Wistar Kyoto rats maintained on diets enriched with coconut, fish or olive oil were compared with animals receiving normal diet for 8 weeks. After 8 weeks of dietary regimen, and while on respective diets, animals were exposed to air or 0.8 ppm ozone for 4 hours per day for 2 consecutive days and necropsies were performed post air or ozone exposure within 2 hours. Body weights, food consumption and body composition were assessed during dietary regimen. At necropsy, livers were stained for lipids, serum lipids and metabolic hormones were assessed, and liver, muscle and adipose tissues are assessed for gene expression using targeted Illumina sequencing for selected genes. Based on reviewers comments during revision period, circulating n-3, n-6, n-9 and unsaturated fatty acids were assessed in the serum through collaboration with Jenifer I. Fenton and Travis Goeden, Michigan State University where samples were shipped for analysis of these lipids using mass spectrometry. These data were incorporated in the manuscript (Table 1) and part of figure 3. This dataset is associated with the following publication: Snow, S., A. Henriquez, W. Cheng, A. Fisher, B. Vallanat, M. Angrish, J. Richards, M.C. Schladweiler, C. Wood, H. Tong, and U. Kodavanti. Diets Enriched with Coconut, Fish, and Olive Oil Modify Peripheral Metabolic Effects of Ozone in Rats. TOXICOLOGY AND APPLIED PHARMACOLOGY. Academic Press Incorporated, Orlando, FL, USA, 410(1): 115337, (2020).

In this study male Wistar Kyoto rats maintained on diets enriched with coconut, fish or olive oil were compared with animals receiving normal diet for 8 weeks. After 8 weeks of dietary regimen, and while on respective diets, animals were exposed to air or 0.8 ppm ozone for 4 hours per day for 2 consecutive days and necropsies were performed post air or ozone exposure within 2 hours. Body weights, food consumption and body composition were assessed during dietary regimen. At necropsy, livers were stained for lipids, serum lipids and metabolic hormones were assessed, and liver, muscle and adipose tissues are assessed for gene expression using targeted Illumina sequencing for selected genes. Based on reviewers comments during revision period, circulating n-3, n-6, n-9 and unsaturated fatty acids were assessed in the serum through collaboration with Jenifer I. Fenton and Travis Goeden, Michigan State University where samples were shipped for analysis of these lipids using mass spectrometry. These data were incorporated in the manuscript (Table 1) and part of figure 3. This dataset is associated with the following publication: Snow, S., A. Henriquez, W. Cheng, A. Fisher, B. Vallanat, M. Angrish, J. Richards, M.C. Schladweiler, C. Wood, H. Tong, and U. Kodavanti. Diets Enriched with Coconut, Fish, and Olive Oil Modify Peripheral Metabolic Effects of Ozone in Rats. TOXICOLOGY AND APPLIED PHARMACOLOGY. Academic Press Incorporated, Orlando, FL, USA, 410(1): 115337, (2020).

This data set was used for the manuscript titled "Ozone-induced Changes in Oxidative Stress Parameters in Brain regions of Adult, Middle-age, and Senescent Brown Norway Rats". It includes various biochemical endpoints and neurobehavior. This dataset is associated with the following publication: Kodavanti, P.R., M. Valdez, J. Richards, D. Agina-Obu, P. Phillips, K. Jarema, and U. Kodavanti. Ozone-induced changes in oxidative stress parameters in brain regions of adult, middle-age, and senescent Brown Norway rats. TOXICOLOGY AND APPLIED PHARMACOLOGY. Academic Press Incorporated, Orlando, FL, USA, 410: 115351, (2020).

This data set was used for the manuscript titled "Ozone-induced Changes in Oxidative Stress Parameters in Brain regions of Adult, Middle-age, and Senescent Brown Norway Rats". It includes various biochemical endpoints and neurobehavior. This dataset is associated with the following publication: Kodavanti, P.R., M. Valdez, J. Richards, D. Agina-Obu, P. Phillips, K. Jarema, and U. Kodavanti. Ozone-induced changes in oxidative stress parameters in brain regions of adult, middle-age, and senescent Brown Norway rats. TOXICOLOGY AND APPLIED PHARMACOLOGY. Academic Press Incorporated, Orlando, FL, USA, 410: 115351, (2020).

we hypothesized that ozone-adaptation is linked to diminution of neuroendocrine stress-axes activation and glucocorticoid levels. Male Wistar-Kyoto-rats (12-week-old) were injected with vehicle or a therapeutically-relevant dexamethasone dose (0.01-mg/kg/day; intraperitoneal) for 1-month to determine if suppression of glucocorticoid signaling was linked to adaptation. Vehicle- and dexamethasone-treated rats were exposed to air or 0.8-ppm ozone, 4 hours/dayx2 or 4 days to assess the impacts of acute exposure and adaptation, respectively. This dataset is associated with the following publication: Heinriquez, A., S. Snow, J. Dye, M.C. Schladweiler, D. Alewel, C. Miller, and U. Kodavanti. The contribution of the neuroendocrine system to adaption after repeated daily ozone exposure in rats. TOXICOLOGY AND APPLIED PHARMACOLOGY. Academic Press Incorporated, Orlando, FL, USA, 447(116085): 1, (2022).