Data Table for Figures

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This excel file contains 7 tabs, each tabs contains the data for one specific figure in the paper. Description of the data and column names is also provided in each tab. This dataset is associated with the following publication: Wang, J., D. Hallinger, A. Murr, A. Buckalew, S. Simmons, S. Laws, and T. Stoker. High-Throughput Screening and Quantitative Chemical Ranking for Sodium Iodide Symporter Inhibitors in ToxCast Phase 1 Chemical Library. ENVIRONMENTAL SCIENCE & TECHNOLOGY. American Chemical Society, Washington, DC, USA, 52(9): 5417-5426, (2018).

Data tables, and data used in figures presented in the manuscript "High-Throughput Screening and Chemotype-Enrichment Analysis of ToxCast Phase II Chemicals Evaluated for Human Sodium-Iodide Symporter (NIS) Inhibition"

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All tables, plus the data for generating figures presented in the manuscript "High-Throughput Screening and Chemotype-Enrichment Analysis of ToxCast Phase II Chemicals Evaluated for Human Sodium-Iodide Symporter (NIS) Inhibition". This dataset is associated with the following publication: Wang, J., D. Hallinger, A. Murr, A. Buckalew, R. Lougee, A. Richard, S. Laws, and T. Stoker. High-Throughput Screening and Chemotype-Enrichment Analysis of ToxCast Phase II Chemicals Evaluated for Human Sodium-Iodide Symporter (NIS) Inhibition. ENVIRONMENT INTERNATIONAL. Elsevier B.V., Amsterdam, NETHERLANDS, 377-386, (2019).

DEVELOPMENT OF A SCREENING APPROACH TO DETECT THYROID DISRUPTING CHEMICALS THAT INHIBIT THE HUMAN SODIUM IODIDE SYMPORTER (NIS)

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Data pertaining to a NIS-expressing cell line, hNIS-HEK293T-EPA, and its screening capabilities for determining inhibitors of NIS-mediated iodide uptake. This dataset is associated with the following publication: Hallinger, D., A. Murr, A. Buckalew, S. Simmons, T. Stoker, and S. Laws. Development of a Screening Approach to Detect Thyroid Disrupting Chemicals that Inhibit the Human Sodium/Iodide Symporter (NIS). TOXICOLOGY IN VITRO. Elsevier Science Ltd, New York, NY, USA, 66-78, (2017).

DEVELOPMENT OF A SCREENING APPROACH TO DETECT THYROID DISRUPTING CHEMICALS THAT INHIBIT THE HUMAN SODIUM IODIDE SYMPORTER (NIS)

공공데이터포털

Data pertaining to a NIS-expressing cell line, hNIS-HEK293T-EPA, and its screening capabilities for determining inhibitors of NIS-mediated iodide uptake. This dataset is associated with the following publication: Hallinger, D., A. Murr, A. Buckalew, S. Simmons, T. Stoker, and S. Laws. Development of a Screening Approach to Detect Thyroid Disrupting Chemicals that Inhibit the Human Sodium/Iodide Symporter (NIS). TOXICOLOGY IN VITRO. Elsevier Science Ltd, New York, NY, USA, 66-78, (2017).

Dataset 1: data in figures. Dataset 2: SI Tables.

공공데이터포털

Dataset for the publication "Expanded High-Throughput Screening and Chemotype-Enrichment Analysis of the Phase II:e1k ToxCast Library for Human Sodium-Iodide Symporter (NIS) Inhibition". https://doi.org/10.1007/s00204-021-03006-2 Dataset1 contains data for figures. Dataset2 contains all supplemental tables data. This dataset is associated with the following publication: Wang, J., A. Richard, A. Murr, A. Buckalew, R. Lougee, M.A. Shobair, D. Hallinger, S. Laws, and T. Stoker. Expanded High-Throughput Screening and Chemotype-Enrichment Analysis of the Phase II:e1k ToxCast Library for Human Sodium-Iodide Symporter (NIS) Inhibition. Archives of Toxicology. Springer, New York, NY, USA, 95(5): 1723-1737, (2021).

FRTL-5 RAIU of 5-AT

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Iodide uptake following a two-hour incubation with concentrations of 5-ATcompared to control iodide uptake in FRTL thyroid follicular cells. This dataset is associated with the following publication: Adams, V., M. Bazar, E. Reinke, A. Buckalew, and W. Eck. In vitro and in vivo effects of 5-Aminotetrazole (5-AT)- an energetic compound. REGULATORY TOXICOLOGY AND PHARMACOLOGY. Elsevier Science Ltd, New York, NY, USA, 111(104573): 1, (2020).

Secondary screening method for sodium-iodide symporter inhibition utilizing FRTL-5 cells data set

공공데이터포털

Data pertaining to a NIS-expressing cell line, FRTL-5 and it's screening capabilities for confirming inhibitors of NIS-mediated iodide uptake. This dataset is associated with the following publication: Buckalew, A., J. Wang, A. Murr, C. Deisenroth, W. Stewart, T. Stoker, and S. Laws. Evaluation of potential sodium-iodide symporter (NIS) inhibitors using a secondary Fischer rat thyroid follicular cell (FRTL-5) radioactive iodide uptake (RAIU) assay. Archives of Toxicology. Springer, New York, NY, USA, 94(3): 873-885, (2020).

Ramjoh PFHxS Data

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File contains data on body, liver, thyroid weights from dams and exposed offspring, serum thyroid hormones, gland and cortical gene expression, results of cognitive function tests. This dataset is associated with the following publication: Ramhoj, L., U. Haas, M. Gilbert, C. Wood, T. Svingen, D. Usai, A.M. Vinggaard, K. Mandrup, and M. Axelstad. Evaluating thyroid hormone disruption: Investigations of long-term neurodevelopmental effects in rats after perinatal exposure to perfluorohexane sulfonate (PFHxS). Scientific Reports. Nature Publishing Group, London, UK, 10(1): 2672, (2020).

Ramjoh PFHxS Data

공공데이터포털

File contains data on body, liver, thyroid weights from dams and exposed offspring, serum thyroid hormones, gland and cortical gene expression, results of cognitive function tests. This dataset is associated with the following publication: Ramhoj, L., U. Haas, M. Gilbert, C. Wood, T. Svingen, D. Usai, A.M. Vinggaard, K. Mandrup, and M. Axelstad. Evaluating thyroid hormone disruption: Investigations of long-term neurodevelopmental effects in rats after perinatal exposure to perfluorohexane sulfonate (PFHxS). Scientific Reports. Nature Publishing Group, London, UK, 10(1): 2672, (2020).

180626 Thyroid Hormone PFOA PFOS Manuscript Data

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180626 Thyroid Hormone PFOA PFOS Manuscript Data. This dataset is associated with the following publication: Selano, J., V. Richardson, J. Washington, and C. Mazur. Characterization of non-radiolabeled Thyroxine (T4) uptake in cryopreserved rat hepatocyte suspensions: Pharmacokinetic implications for PFOA and PFOS chemical exposure. TOXICOLOGY IN VITRO. Elsevier Science Ltd, New York, NY, USA, 58: 230-238, (2019).