MEA 86 Compound data

공공데이터포털

This data file contains the full raw parameter data for the 86 compounds tested in the developmental MEA assay, as well as Area Under the Curve (AUC) calculations and plate normalized data.

Provides an overview of the analysis and associated files, scripts and datasets

공공데이터포털

This dataset contains the files, scripts and data that were used to run the simulations and data analyses for the manuscript. This dataset is associated with the following publication: Ball, K., C. Grant, W. Mundy, and T. Shafer. A multivariate extension of mutual information for growing neural networks.. Neural Networks. Elsevier B.V., Amsterdam, NETHERLANDS, 95: 29-43, (2017).

Provides an overview of the analysis and associated files, scripts and datasets

공공데이터포털

This dataset contains the files, scripts and data that were used to run the simulations and data analyses for the manuscript. This dataset is associated with the following publication: Ball, K., C. Grant, W. Mundy, and T. Shafer. A multivariate extension of mutual information for growing neural networks.. Neural Networks. Elsevier B.V., Amsterdam, NETHERLANDS, 95: 29-43, (2017).

NHEERL MEA Toxcast Single Concentration Screening data

공공데이터포털

This file contains the data used to generate hit calls from neural activity recordings on microelectrode array (MEA) plates treated with ToxCast compounds at a single concentration. This dataset is associated with the following publication: Strickland, J., M. Martin, A. Richard, K. Houck, and T. Shafer. Screening the ToxCast phase II libraries for alterations in network function using cortical neurons grown on multi-well microelectrode array (mwMEA) plates. Archives of Toxicology. Springer, New York, NY, USA, 92(1): 487-500, (2018).

NHEERL MEA Toxcast Single Concentration Screening data

공공데이터포털

This file contains the data used to generate hit calls from neural activity recordings on microelectrode array (MEA) plates treated with ToxCast compounds at a single concentration. This dataset is associated with the following publication: Strickland, J., M. Martin, A. Richard, K. Houck, and T. Shafer. Screening the ToxCast phase II libraries for alterations in network function using cortical neurons grown on multi-well microelectrode array (mwMEA) plates. Archives of Toxicology. Springer, New York, NY, USA, 92(1): 487-500, (2018).

Dataset for Chemical Signatures of neurodevelopmental disorders

공공데이터포털

This dataset contains the data, code and associated files for the manuscript Authored by Marable et al. This dataset is associated with the following publication: Marable, C., C. Frank, R. Seim, S. Hester, M. Henderson, B. Chorley, and T. Shafer. Integrated Omic Analyses Identify Pathways and Transcriptomic Regulators Associated with Chemical Alterations of in vitro Neural Network Formation. TOXICOLOGICAL SCIENCES. Society of Toxicology, RESTON, VA, 186(1): 118-133, (2022).

Dataset for Chemical Signatures of neurodevelopmental disorders

공공데이터포털

This dataset contains the data, code and associated files for the manuscript Authored by Marable et al. This dataset is associated with the following publication: Marable, C., C. Frank, R. Seim, S. Hester, M. Henderson, B. Chorley, and T. Shafer. Integrated Omic Analyses Identify Pathways and Transcriptomic Regulators Associated with Chemical Alterations of in vitro Neural Network Formation. TOXICOLOGICAL SCIENCES. Society of Toxicology, RESTON, VA, 186(1): 118-133, (2022).

Data for Brown et al MEA Developmental Neurotoxicity Screening Manuscript

공공데이터포털

These data are the individual parameter and well-level data that were support the conclusions in Brown et al. Note: the parameters CVtime and CVnetwork were not used. This dataset is associated with the following publication: Brown, J., D. Hall, C. Frank, K. Wallace, W. Mundy, and T. Shafer. Editor's highlight: Evaluation of a Microelectrode Array-based Assay for Neural Network Ontogeny using Training Set Chemicals. TOXICOLOGICAL SCIENCES. Society of Toxicology, 154(1): 126-139, (2016).

Data for Brown et al MEA Developmental Neurotoxicity Screening Manuscript

공공데이터포털

These data are the individual parameter and well-level data that were support the conclusions in Brown et al. Note: the parameters CVtime and CVnetwork were not used. This dataset is associated with the following publication: Brown, J., D. Hall, C. Frank, K. Wallace, W. Mundy, and T. Shafer. Editor's highlight: Evaluation of a Microelectrode Array-based Assay for Neural Network Ontogeny using Training Set Chemicals. TOXICOLOGICAL SCIENCES. Society of Toxicology, 154(1): 126-139, (2016).

Data for: Evaluation of Chemical Effects on Network Formation in Cortical Neurons Grown on Microelectrode Arrays

공공데이터포털

This dataset contains the raw data, Area under the curve measurements and EC50 values for effects of 146 compounds (136 unique plus 10 biological replicates) on parameters of network development measured in vitro. There are 17 parameters plus 2 measures of viability. In addition, the data for the ranking of potency and selectivity are provided, as well as data for the comparisons to other ToxCast assays and in vitro to in vivo extrapolations. This dataset is associated with the following publication: Shafer, T., J. Brown, B. Lynch, S. Davila-Montero, K. Wallace, and K. Paul-Friedman. Evaluation of Chemical Effects on Network Formation in Cortical Neurons Grown on Microelectrode Arrays. TOXICOLOGICAL SCIENCES. Society of Toxicology, RESTON, VA, 169(2): 436-455, (2019).