Data collected during the comparison of ozone responsiveness in primary bronchial epithelial cells from a range of distinct donors. This dataset is associated with the following publication: Bowers, E., S. McCullough, D. Morgan, L. Dailey, and D. Diaz-Sanchez. ERK1/2 and p38 regulate inter-individual variability in ozone-mediated IL-8 gene expression in primary human bronchial epithelial cells. Scientific Reports. Nature Publishing Group, London, UK, 8(1): 9398, (2018).

Data collected during the comparison of ozone responsiveness in primary bronchial epithelial cells from a range of distinct donors. This dataset is associated with the following publication: Bowers, E., S. McCullough, D. Morgan, L. Dailey, and D. Diaz-Sanchez. ERK1/2 and p38 regulate inter-individual variability in ozone-mediated IL-8 gene expression in primary human bronchial epithelial cells. Scientific Reports. Nature Publishing Group, London, UK, 8(1): 9398, (2018).

These data are published in a manuscript entitled Multi-tissue transcriptomic and serum metabolomic assessment reveals systemic implications of acute ozone-induced stress response in male Wistar Kyoto rats in the journal Metabolomics. This analyses explored systemic transcriptomic and circulating metabolomic effects of inhaled ozone exposure in rats. This dataset is associated with the following publication: Jackson, T., J. House, A. Henriquez, M. Schladweiler, K.M. Jackson, A. Astriab Fisher, S. Snow , D. Alewel, A. Motsinger-Reif, and U. Kodavanti. Multi-tissue transcriptomic and serum metabolomic assessment reveals systemic implications of acute ozone-induced stress response in male Wistar Kyoto rats. Metabolomics. Plenum Press, New York, NY, USA, 19: 81, (2023).

Pulmonary gene expression related to the regulation of DNA methylation following an exposure to ozone in rats. Epigenetic regulation of a pulmonary hypertensive gene, apelin, was also quantified. This dataset is associated with the following publication: Miller, C., J. Dye, M. Schladweiler, J. Richards, A. Ledbetter, E. Stewart, and U. Kodavanti. Acute inhalation of ozone induces DNA methylation of apelin in lungs of Long-Evans rats.. INHALATION TOXICOLOGY. Taylor & Francis, Inc., Philadelphia, PA, USA, 30(4): 178-186, (2018).

A manuscript describing the independent roles of beta adrenergic and glucocorticoid receptors in mediating ozone-induced pulmonary and systemic effects. This dataset is associated with the following publication: Henriquez, A., S. Snow, M.C. Schladweiler, C. Miller, and U. Kodavanti. Independent roles of beta-adrenergic and glucocorticoid receptors in systemic and pulmonary effects of ozone. INHALATION TOXICOLOGY. Taylor & Francis, Inc., Philadelphia, PA, USA, 32(4): 155-169, (2020).

This data set pertains to the manuscript "Exacerbation of ozone-induced pulmonary and systemic effects by 2-adrenergic and/or glucocorticoid agonist/s". It shows the raw data for each figure in the manuscript that is created with these data. Basically examining the influence of beta adrenergic and glucocorticoid receptor agonists on ozone-induced lung injury and inflammation. This dataset is associated with the following publication: Henriquez, A., S. Snow, M. Schladweiler, C. Miller, J. Dye, A. Ledbetter, M. Hargrove, U. Kodavanti, and J. Richards. Exacerbation of ozone-induced pulmonary and systemic effects by beta2-adrenergic and/or glucocorticoid agonist/s. Scientific Reports. Nature Publishing Group, London, UK, 9(1): 17925, (2019).

This data set provides the biological endpoints collected from individual animals that culminated into a published paper. This dataset is associated with the following publication: Snow, S., C. Gordon , V. Bass, M. Schladweiler , A. Ledbetter , K. Jarema , P. Phillips , A. Johnstone , and U. Kodavanti. Age-related differences in pulmonary effects of acute and subchronic episodic ozone exposures in Brown Norway rats. INHALATION TOXICOLOGY. Informa Healthcare USA, New York, NY, USA, 28(7): 313-23, (2016).

This data set provides the biological endpoints collected from individual animals that culminated into a published paper. This dataset is associated with the following publication: Snow, S., C. Gordon , V. Bass, M. Schladweiler , A. Ledbetter , K. Jarema , P. Phillips , A. Johnstone , and U. Kodavanti. Age-related differences in pulmonary effects of acute and subchronic episodic ozone exposures in Brown Norway rats. INHALATION TOXICOLOGY. Informa Healthcare USA, New York, NY, USA, 28(7): 313-23, (2016).

we hypothesized that ozone-adaptation is linked to diminution of neuroendocrine stress-axes activation and glucocorticoid levels. Male Wistar-Kyoto-rats (12-week-old) were injected with vehicle or a therapeutically-relevant dexamethasone dose (0.01-mg/kg/day; intraperitoneal) for 1-month to determine if suppression of glucocorticoid signaling was linked to adaptation. Vehicle- and dexamethasone-treated rats were exposed to air or 0.8-ppm ozone, 4 hours/dayx2 or 4 days to assess the impacts of acute exposure and adaptation, respectively. This dataset is associated with the following publication: Heinriquez, A., S. Snow, J. Dye, M.C. Schladweiler, D. Alewel, C. Miller, and U. Kodavanti. The contribution of the neuroendocrine system to adaption after repeated daily ozone exposure in rats. TOXICOLOGY AND APPLIED PHARMACOLOGY. Academic Press Incorporated, Orlando, FL, USA, 447(116085): 1, (2022).

This dataset provides key data files and scripts used in the analysis for the published manuscript "Changes in ozone chemical sensitivity in the U.S. from 2007 to 2016" ; https://pubs.acs.org/doi/abs/10.1021/acsenvironau.1c00029. Citation information for this dataset can be found in the EDG's Metadata Reference Information section and Data.gov's References section.