Datasets used in ORD-023401: Activation of Nrf2 in the Liver is Associated with Suppression of the Growth Hormone-Regulated STAT5b Transcription Factor

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Datasets used in ORD-023401: Activation of Nrf2 in the Liver is Associated with Suppression of the Growth Hormone-Regulated STAT5b Transcription Factor. This dataset is associated with the following publication: Rooney, J., K. Oshida, N. Vasani, B. Vallanat, N. Ryan, B. Chorley, X. Wang, D. Bell, K. Wu, L. Aleksunes, C. Klaassen, T. Kensler, and C. Corton. Activation of Nrf2 in the Liver is Associated with Suppression of the Growth Hormone-Regulated STAT5b Transcription Factor. PLoS ONE. Public Library of Science, San Francisco, CA, USA, 13(8): 1-30, (2018).

Dataset used in ORD-035008 - A Set of Six Gene Expression Biomarkers and Their Thresholds Identify Rat Liver Tumorigens in Short-Term Assays

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The links provided include the DrugMatrix-Affymetrix study, the TG-GATES study, and the TempO-Seq S1500+ study. This dataset is associated with the following publication: Lewis, R., T. Hill III, and C. Corton. A set of six Gene expression biomarkers and their thresholds identify rat liver tumorigens in short-term assays. TOXICOLOGY. Elsevier Science Ltd, New York, NY, USA, 443: 152547, (2020).

Dataset for ORD-033344: A Set of Six Gene Expression Biomarkers Identify Rat Liver Tumorigens in Short-Term Assays

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Microarray experiments used in the study. This dataset is associated with the following publication: Corton, J., T. Hill, J. Sutherland, J. Stevens, and J. Rooney. A Set of Six Gene Expression Biomarkers Identify Rat Liver Tumorigens in Short-Term Assays. TOXICOLOGICAL SCIENCES. Society of Toxicology, RESTON, VA, 177(1): 11-26, (2020).

Dataset for ORD-040059: Identification of Chemical Modulators of NF-κB Using a Gene Expression Biomarker Approach

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Dataset used in ORD-040059: Identification of Chemical Modulators of NF-κB Using a Gene Expression Biomarker Approach that includes publicaly available microarray datasets. This dataset is associated with the following publication: Korunes, K., J. Liu, R. Huang, M. Xia, K. Houck, and C. Corton. A gene expression biomarker for predictive toxicology to identify chemical modulators of NF-κB. PLOS ONE. Public Library of Science, San Francisco, CA, USA, 17(2): e0261854, (2022).

Dataset for ORD-033372: Biological Thresholds Derived from Common Measures in Rat Studies are Predictive of Liver Tumorigenic Chemicals

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Microarray experiments used in the study. This dataset is associated with the following publication: Corton, J., K. Korunes, J. Abedini, H. El-Masri, J. Brown, K. Friedman, Y. Liu, C. Martini, S. He, and J. Rooney. Thresholds Derived from Common Measures in Rat Studies are Predictive of Liver Tumorigenic Chemicals. TOXICOLOGIC PATHOLOGY. Society of Toxicology, RESTON, VA, 48(7): 857-874, (2020).

Dataset for ORD-033373: Gene Expression Thresholds Are Predictive of Rat Liver Tumorigens in Short-Term Assays

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The microarray experiments used in the study. This dataset is associated with the following publication: Hill, T., J. Rooney, J. Abedini, H. El-Masri, C. Wood, and J. Corton. Gene Expression Thresholds Derived From Short-term Exposures Identify Rat Liver Tumorigens. TOXICOLOGICAL SCIENCES. Society of Toxicology, RESTON, VA, 177(1): 41-59, (2020).

Dataset for ORD-033294: Mining a human transcriptome database for chemical modulators of NRF2

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Gene Expression Omnibus and ArrayExpress archived study numbers of microarray data used in the study. This dataset is associated with the following publication: Rooney, J., B. Chorley, S. Hiemstra, S. Wink, X. Wang, D. Bell, B. van de Water, and J. Corton. Mining a human transcriptome database for chemical modulators of Nrf2 (PLOS ONE). PLoS ONE. Public Library of Science, San Francisco, CA, USA, 15(9): e0239367, (2020).

Datasets in Gene Expression Omnibus used in the study ORD-020969: Genomic effects of androstenedione and sex-specific liver cancer susceptibility in mice

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Datasets in Gene Expression Omnibus used in the study ORD-020969: Genomic effects of androstenedione and sex-specific liver cancer susceptibility in mice. This dataset is associated with the following publication: Rooney, J., N. Ryan, B. Chorley, S. Hester, E. Kenyon, J. Schmid, B. George, M. Hughes, Y. Sey, A. Tennant, D. MacMillan, J. Simmons, C. McQueen, A. Pandiri, C. Wood, and C. Corton. Genomic effects of androstenedione and sex-specific liver cancer susceptibility in mice. TOXICOLOGICAL SCIENCES. Society of Toxicology, 160(1): 15–29, (2017).

Dataset associated with ORD-025118: Using a Gene Expression Biomarker to Identify DNA Damage-Inducing Agents in Microarray Profiles

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Datasets used in ORD-025118: Using a Gene Expression Biomarker to Identify DNA Damage-Inducing Agents in Microarray Profiles. This dataset is associated with the following publication: Corton, C., A. Williams, and C. Yauk. Using a Gene Expression Biomarker to Identify DNA Damage-Inducing Agents in Microarray Profiles. ENVIRONMENTAL AND MOLECULAR MUTAGENESIS. John Wiley & Sons, Inc, Hoboken, NJ, USA, 59(9): 772-784, (2018).

Dataset for journal article 'Determinants of gene expression in the human liver: Impact of aging and sex on xenobiotic metabolism'

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Gene array data files compared gene expression profiles in liver samples from young (21-45 years) and old (69+ years) men and women to determine changes in the expression of xenobiotic metabolism enzymes and transporters. We identified genes that were differentially expressed in males only, females only, or in all individuals between the young and old using microarray. This dataset is associated with the following publication: Corton, J., J. Lee, J. Liu, H. Ren, B. Vallanat, and M. Devito. Determinants of Gene Expression in the Human Liver: Impact of Aging and Sex on Xenobiotic Metabolism. Experimental Gerontology. Elsevier Science Ltd, New York, NY, USA, 169: 111976, (2022).