genomic and endocrine effects of in utero p[hthalates

공공데이터포털

effects of in utero phthalate and other chemical administration on male rat sexual differentiation: Non PPAR mediated AOP. This dataset is associated with the following publication: Gray, E., J. Conley, C. Lambright, N. Evans, J. Furr, V. Wilson, B. Hannas, P. Foster, and H. Sampson. Genomic and Hormonal Biomarkers of Phthalate-induced Male Rat Reproductive Developmental Toxicity: Part II A Targeted RT-qPCR Array Approach that Defines a Unique Adverse Outcome Pathway.. TOXICOLOGICAL SCIENCES. Society of Toxicology, RESTON, VA, 182(2): 195-214, (2021).

biological relevance of reductions of testosterone production on the adverse effects of in utero phthalate combinations

공공데이터포털

RAW DATA, SAS FILES AND DATA MEANS. This dataset is associated with the following publication: Howdeshell, K., C. Rider, V. Wilson , J. Furr , C. Lambright , and E. Gray. Dose addition models based on biologically-relevant reductions in fetal testosterone accurately predict postnatal reproductive tract alterations by a phthalate mixture in rats. TOXICOLOGICAL SCIENCES. Society of Toxicology, 148(2): 488-502, (2015).

biological relevance of reductions of testosterone production on the adverse effects of in utero phthalate combinations

공공데이터포털

RAW DATA, SAS FILES AND DATA MEANS. This dataset is associated with the following publication: Howdeshell, K., C. Rider, V. Wilson , J. Furr , C. Lambright , and E. Gray. Dose addition models based on biologically-relevant reductions in fetal testosterone accurately predict postnatal reproductive tract alterations by a phthalate mixture in rats. TOXICOLOGICAL SCIENCES. Society of Toxicology, 148(2): 488-502, (2015).

Establishing the “Biological Relevance” of Dipentyl Phthalate Reductions in Fetal Rat Testosterone Production and Plasma and Testis Testosterone Levels

공공데이터포털

metadata sheet, data sheet for each table and figure in the published manuscript. This dataset is associated with the following publication: Gray , E., J. Furr , K. Tatum-Gibbs, C. Lambright , H. Sampson, B. Hannas, V. Wilson , A. Hotchkiss , and P. Foster. Establishing the Biological Relevance of Dipentyl Phthalate Reductions in Fetal Rat Testosterone Production and Plasma and Testis Testosterone Levels. TOXICOLOGICAL SCIENCES. Society of Toxicology, 149(1): 178-91, (2016).

Establishing the “Biological Relevance” of Dipentyl Phthalate Reductions in Fetal Rat Testosterone Production and Plasma and Testis Testosterone Levels

공공데이터포털

metadata sheet, data sheet for each table and figure in the published manuscript. This dataset is associated with the following publication: Gray , E., J. Furr , K. Tatum-Gibbs, C. Lambright , H. Sampson, B. Hannas, V. Wilson , A. Hotchkiss , and P. Foster. Establishing the Biological Relevance of Dipentyl Phthalate Reductions in Fetal Rat Testosterone Production and Plasma and Testis Testosterone Levels. TOXICOLOGICAL SCIENCES. Society of Toxicology, 149(1): 178-91, (2016).

Validation of an automated counting procedure for phthalate-induced testicular multinucleated germ cells

공공데이터포털

the dataset contains NHEERL collected data on fetal male rat gestational day 18 testicular testosterone production and related data. This dataset is associated with the following publication: spade, d., C. Yue Bai , C. Lambright, J. Conley, K. Boekelheide , and E. Gray. Validation of an automated counting procedure for phthalate-induced testicular multinucleated germ cells. TOXICOLOGY LETTERS. Elsevier Science Ltd, New York, NY, USA, 290: 55-61, (2018).

Gray 2025 Phthalate transcriptomic and apical points of departure dataset

공공데이터포털

Dataset includes all endpoint measurements from studies described in the manuscript and SAS code for statistical analyses of data. This dataset is associated with the following publication: Gray, L., C. Lambright, N. Evans, J. Ford, and J. Conley. Comparison of in utero phthalate exposure on fetal rat testis transcript and endocrine alterations with apical reproductive alterations in male rats. TOXICOLOGY AND APPLIED PHARMACOLOGY. Elsevier B.V., Amsterdam, NETHERLANDS, 502: 117447, (2025).

ConleyJustin A-b5mz Dataset 20201021

공공데이터포털

This dataset is limited to the human counting values of multinucleated germ cells in treatment-blinded images of rat fetal testes conducted by EPA researcher Justin Conley for comparison by collaborators at Brown University to germ cell counts made using an automated method created by the collaborators. This dataset is associated with the following publication: Bell, S., A. Zsom, J. Conley, and D. Spade. Automated identification of multinucleated germ cells with U-Net. PLoS ONE. Public Library of Science, San Francisco, CA, USA, 15(7): e0229967, (2020).

ConleyJustin A-b5mz Dataset 20201021

공공데이터포털

This dataset is limited to the human counting values of multinucleated germ cells in treatment-blinded images of rat fetal testes conducted by EPA researcher Justin Conley for comparison by collaborators at Brown University to germ cell counts made using an automated method created by the collaborators. This dataset is associated with the following publication: Bell, S., A. Zsom, J. Conley, and D. Spade. Automated identification of multinucleated germ cells with U-Net. PLoS ONE. Public Library of Science, San Francisco, CA, USA, 15(7): e0229967, (2020).

Data set for a PFAS pestilcide pyrifluquinazon + dibutyl phthalate in utero mixture on male rat offspring reproductive development. Dose Additive effects of dissimilarly acting toxicants

공공데이터포털

data set has a description of the information in the excell file and all the data used in the study. This dataset is associated with the following publication: Gray, E., J. Conley, C. Lambright, and J. Furr. In utero exposure to a mixture of the perfluoroalkylisopropyl pesticide pyrifluquinazon with dibutyl phthalate cumulatively disrupts male rat reproductive development via different mechanisms of action. TOXICOLOGICAL SCIENCES. Society of Toxicology, RESTON, VA, 188(2): 234-247, (2022).